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Shroom4 shroom family member 4 [ Mus musculus (house mouse) ]

Gene ID: 208431, updated on 2-Nov-2024

Summary

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Official Symbol
Shroom4provided by MGI
Official Full Name
shroom family member 4provided by MGI
Primary source
MGI:MGI:2685570
See related
Ensembl:ENSMUSG00000068270 AllianceGenome:MGI:2685570
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm724; Shrm4; D430043L16Rik
Summary
Enables actin filament binding activity and myosin II binding activity. Acts upstream of or within actin filament organization. Located in several cellular components, including apical plasma membrane; basal plasma membrane; and stress fiber. Colocalizes with cortical actin cytoskeleton. Is expressed in several structures, including brain; genitourinary system; heart; liver; and lung. Orthologous to human SHROOM4 (shroom family member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in kidney adult (RPKM 3.7), lung adult (RPKM 2.9) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Shroom4 in Genome Data Viewer
Location:
X A1.1; X 2.85 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (6312012..6549508)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (6399949..6637454)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 46685 Neighboring gene STARR-seq mESC enhancer starr_46655 Neighboring gene bone morphogenetic protein 15 Neighboring gene RIKEN cDNA 5430428K19 gene Neighboring gene STARR-seq mESC enhancer starr_46656 Neighboring gene STARR-seq mESC enhancer starr_46657 Neighboring gene STARR-seq mESC enhancer starr_46658 Neighboring gene diacylglycerol kinase kappa Neighboring gene STARR-seq mESC enhancer starr_46659 Neighboring gene cyclin B3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Overexpression of Shrm4 promotes proliferation and differentiation of neural stem cells through activation of GABA signaling pathway. Tian R, et al. Mol Cell Biochem, 2020 Jan. PMID 31654185
  2. X-linked variations in SHROOM4 are implicated in congenital anomalies of the urinary tract and the anorectal, cardiovascular and central nervous systems. Kolvenbach CM, et al. J Med Genet, 2023 Jun. PMID 36379543, Free PMC Article
  3. Shroom4 (Kiaa1202) is an actin-associated protein implicated in cytoskeletal organization. Yoder M, et al. Cell Motil Cytoskeleton, 2007 Jan. PMID 17009331
  4. Disruptions of the novel KIAA1202 gene are associated with X-linked mental retardation. Hagens O, et al. Hum Genet, 2006 Jan. PMID 16249884
  5. A new standard nomenclature for proteins related to Apx and Shroom. Hagens O, et al. BMC Cell Biol, 2006 Apr 14. PMID 16615870, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. X-linked variations in SHROOM4 are implicated in congenital anomalies of the urinary tract and the anorectal, cardiovascular and central nervous systems.
    Title: X-linked variations in SHROOM4 are implicated in congenital anomalies of the urinary tract and the anorectal, cardiovascular and central nervous systems.
  2. the overexpression of Shrm4 or activation of GABAB1 upregulated the levels of Shrm4, GABAB1, Bcl-2, MAP-2 and SOCS2, while downregulated Bax and cleaved Caspase-3 in NSCs. Overall, overexpression of Shrm4 activated GABAB1 to stimulate the proliferation and differentiation of NSCs.
    Title: Overexpression of Shrm4 promotes proliferation and differentiation of neural stem cells through activation of GABA signaling pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables myosin II binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within actin filament organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in brain development IEA
Inferred from Electronic Annotation
more info
  
involved_in brain development ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in cell morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in cognition IEA
Inferred from Electronic Annotation
more info
  
involved_in cognition ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin filament IEA
Inferred from Electronic Annotation
more info
  
located_in actin filament ISO
Inferred from Sequence Orthology
more info
  
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in apical junction complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
located_in stress fiber IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein Shroom4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040459.2 → NP_001035549.1  protein Shroom4 isoform 1

    See identical proteins and their annotated locations for NP_001035549.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL671501, BC151022
    Consensus CDS
    CCDS29959.1
    UniProtKB/Swiss-Prot
    A2ADV9, B2RX74, Q1W617, Q69ZN9
    Related
    ENSMUSP00000100070.4, ENSMUST00000103005.10
    Conserved Domains (3) summary
    cd00992
    Location:13 → 89
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam08687
    Location:1229 → 1467
    ASD2; Apx/Shroom domain ASD2
    pfam15265
    Location:229 → 375
    FAM196; FAM196 family

  2. NM_001313764.1 → NP_001300693.1  protein Shroom4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in place of the first exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL671501, BC151022, CJ101431
    UniProtKB/Swiss-Prot
    Q1W617
    Conserved Domains (2) summary
    smart00228
    Location:1 → 41
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam08687
    Location:1168 → 1416
    ASD2; Apx/Shroom domain ASD2

  3. NM_001313765.1 → NP_001300694.1  protein Shroom4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate exon in place of the first two exons compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK052531, AK173129, AL671501
    Consensus CDS
    CCDS85744.1
    UniProtKB/Swiss-Prot
    Q1W617
    Related
    ENSMUSP00000086949.3, ENSMUST00000089520.3
    Conserved Domains (1) summary
    pfam08687
    Location:1113 → 1351
    ASD2; Apx/Shroom domain ASD2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    6312012..6549508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527549.5 → XP_006527612.1  protein Shroom4 isoform X1

    Conserved Domains (2) summary
    smart00228
    Location:1 → 41
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam08687
    Location:1168 → 1416
    ASD2; Apx/Shroom domain ASD2

  2. XM_036161879.1 → XP_036017772.1  protein Shroom4 isoform X2

    Conserved Domains (1) summary
    smart00228
    Location:1 → 41
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

RNA

  1. XR_001782743.3 RNA Sequence

  2. XR_004940331.1 RNA Sequence

  3. XR_004940332.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1W617.1 GenPept UniProtKB/Swiss-Prot:Q1W617

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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