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Stac src homology three (SH3) and cysteine rich domain [ Mus musculus (house mouse) ]

Gene ID: 20840, updated on 2-Nov-2024

Summary

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Official Symbol
Stacprovided by MGI
Official Full Name
src homology three (SH3) and cysteine rich domainprovided by MGI
Primary source
MGI:MGI:1201400
See related
Ensembl:ENSMUSG00000032502 AllianceGenome:MGI:1201400
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables transmembrane transporter binding activity. Involved in positive regulation of protein localization to plasma membrane and positive regulation of voltage-gated calcium channel activity. Acts upstream of or within cellular response to heat; muscle contraction; and regulation of voltage-gated calcium channel activity. Located in T-tubule and cytoplasmic side of plasma membrane. Is expressed in lens. Orthologous to human STAC (SH3 and cysteine rich domain). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in bladder adult (RPKM 13.7), cerebellum adult (RPKM 2.5) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Stac in Genome Data Viewer
Location:
9 F3; 9 61.81 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (111386476..111519673, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (111561437..111690588, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25292 Neighboring gene doublecortin-like kinase 3 Neighboring gene STARR-seq mESC enhancer starr_25295 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene, 36088 Neighboring gene predicted gene, 36034 Neighboring gene STARR-seq mESC enhancer starr_25298 Neighboring gene STARR-seq mESC enhancer starr_25299 Neighboring gene STARR-seq mESC enhancer starr_25300 Neighboring gene STARR-seq mESC enhancer starr_25301 Neighboring gene STARR-seq mESC enhancer starr_25302 Neighboring gene RIKEN cDNA 4930545L08 gene Neighboring gene predicted gene, 39430

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Human and mouse chromosomal mapping of Stac, a neuron-specific protein with an SH3 domain. Kawai J, et al. Genomics, 1998 Jan 1. PMID 9465308
  2. Stac, a novel neuron-specific protein with cysteine-rich and SH3 domains. Suzuki H, et al. Biochem Biophys Res Commun, 1996 Dec 24. PMID 8954993
  3. stac1 and stac2 genes define discrete and distinct subsets of dorsal root ganglia neurons. Legha W, et al. Gene Expr Patterns, 2010 Oct-Dec. PMID 20736085
  4. A Ca(v)3.2/Stac1 molecular complex controls T-type channel expression at the plasma membrane. Rzhepetskyy Y, et al. Channels (Austin), 2016 Sep 2. PMID 27149520, Free PMC Article
  5. Stac proteins associate with the critical domain for excitation-contraction coupling in the II-III loop of Ca(V)1.1. Polster A, et al. J Gen Physiol, 2018 Apr 2. PMID 29467163, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC130287, MGC130288

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to heat IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cation channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of voltage-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of voltage-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in skeletal muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in T-tubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SH3 and cysteine-rich domain-containing protein
Names
SRC homology 3 and cysteine-rich domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324546.2 → NP_001311475.1  SH3 and cysteine-rich domain-containing protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a 5' exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC131794, AC161113, CT030122
    UniProtKB/TrEMBL
    Q3UYD4
    Conserved Domains (3) summary
    cd11833
    Location:146 → 198
    SH3_Stac_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing (Stac) proteins
    pfam16664
    Location:23 → 118
    STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2
    cl17036
    Location:205 → 255
    SH3; Src Homology 3 domain superfamily

  2. NM_016853.4 → NP_058549.1  SH3 and cysteine-rich domain-containing protein isoform 1

    See identical proteins and their annotated locations for NP_058549.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC131794, AC161113, CT030122
    Consensus CDS
    CCDS23586.1
    UniProtKB/Swiss-Prot
    P97306
    UniProtKB/TrEMBL
    Q3UPL9
    Related
    ENSMUSP00000035083.8, ENSMUST00000035083.8
    Conserved Domains (4) summary
    cd11833
    Location:290 → 342
    SH3_Stac_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing (Stac) proteins
    cd00029
    Location:109 → 160
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam16664
    Location:167 → 262
    STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2
    cl17036
    Location:349 → 399
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    111386476..111519673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512016.5 → XP_006512079.1  SH3 and cysteine-rich domain-containing protein isoform X1

    Conserved Domains (4) summary
    cd11833
    Location:279 → 331
    SH3_Stac_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing (Stac) proteins
    cd00029
    Location:98 → 149
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam16664
    Location:156 → 204
    STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2
    cl17036
    Location:338 → 388
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97306.1 GenPept UniProtKB/Swiss-Prot:P97306

Gene LinkOut

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