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Asb18 ankyrin repeat and SOCS box-containing 18 [ Mus musculus (house mouse) ]

Gene ID: 208372, updated on 2-Nov-2024

Summary

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Official Symbol
Asb18provided by MGI
Official Full Name
ankyrin repeat and SOCS box-containing 18provided by MGI
Primary source
MGI:MGI:2655109
See related
Ensembl:ENSMUSG00000067081 AllianceGenome:MGI:2655109
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Asb-18
Summary
Predicted to be involved in intracellular signal transduction and protein ubiquitination. Orthologous to human ASB18 (ankyrin repeat and SOCS box containing 18). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in genital fat pad adult (RPKM 5.5), heart adult (RPKM 2.9) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Asb18 in Genome Data Viewer
Location:
1 D; 1 45.06 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (89880313..89942388, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (89952591..90014666, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 Neighboring gene RIKEN cDNA 4933400F21 gene Neighboring gene STARR-seq mESC enhancer starr_01667 Neighboring gene STARR-seq mESC enhancer starr_01669 Neighboring gene STARR-seq mESC enhancer starr_01670 Neighboring gene uncharacterized LOC102637806 Neighboring gene STARR-seq mESC enhancer starr_01674 Neighboring gene gastrulation brain homeobox 2 Neighboring gene predicted gene, 41915 Neighboring gene predicted gene, 34616 Neighboring gene STARR-seq mESC enhancer starr_01676 Neighboring gene IQ motif containing with AAA domain 1 Neighboring gene RIKEN cDNA 4930434B07 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The SOCS box: a tale of destruction and degradation. Kile BT, et al. Trends Biochem Sci, 2002 May. PMID 12076535
  2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 18
Names
SOCS box protein ASB-18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355134.1 → NP_001342063.1  ankyrin repeat and SOCS box protein 18 isoform 2

    Status: VALIDATED

    Source sequence(s)
    BC145621
    UniProtKB/TrEMBL
    A0A571BD84, B7ZP43
    Conserved Domains (4) summary
    cd00204
    Location:81 → 196
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03723
    Location:379 → 426
    SOCS_ASB4_ASB18; SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the ...
    sd00045
    Location:81 → 108
    ANK; ANK repeat [structural motif]
    cl26072
    Location:242 → 325
    Ank_5; Ankyrin repeats (many copies)

  2. NM_139152.2 → NP_631891.1  ankyrin repeat and SOCS box protein 18 isoform 1

    See identical proteins and their annotated locations for NP_631891.1

    Status: VALIDATED

    Source sequence(s)
    AY057054, BC145621
    Consensus CDS
    CCDS15151.1
    UniProtKB/Swiss-Prot
    Q3B7Y5, Q3KNB0, Q8VHA6
    UniProtKB/TrEMBL
    A0A571BD84
    Related
    ENSMUSP00000084095.2, ENSMUST00000086882.8
    Conserved Domains (5) summary
    cd00204
    Location:122 → 237
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03723
    Location:420 → 467
    SOCS_ASB4_ASB18; SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the ...
    pfam12796
    Location:124 → 214
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:283 → 334
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:122 → 149
    ANK; ANK repeat [structural motif]

RNA

  1. NR_149309.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC107370, BC145621
    Related
    ENSMUST00000154228.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    89880313..89942388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247953.4 → XP_011246255.1  ankyrin repeat and SOCS box protein 18 isoform X2

    Conserved Domains (3) summary
    PTZ00322
    Location:254 → 337
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    sd00045
    Location:93 → 120
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:127 → 220
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_011247952.3 → XP_011246254.1  ankyrin repeat and SOCS box protein 18 isoform X1

    Conserved Domains (3) summary
    PTZ00322
    Location:254 → 337
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    sd00045
    Location:93 → 120
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:127 → 220
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VHA6.1 GenPept UniProtKB/Swiss-Prot:Q8VHA6

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