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Rpp40 ribonuclease P 40 subunit [ Mus musculus (house mouse) ]

Gene ID: 208366, updated on 28-Oct-2024

Summary

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Official Symbol
Rpp40provided by MGI
Official Full Name
ribonuclease P 40 subunitprovided by MGI
Primary source
MGI:MGI:1346084
See related
Ensembl:ENSMUSG00000021418 AllianceGenome:MGI:1346084
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rnasep1; D8Bwg1265e
Summary
Predicted to enable ribonuclease P RNA binding activity. Predicted to contribute to ribonuclease MRP activity and ribonuclease P activity. Predicted to be involved in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and tRNA 5'-leader removal. Predicted to be part of nucleolar ribonuclease P complex and ribonuclease MRP complex. Orthologous to human RPP40 (ribonuclease P/MRP subunit p40). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 1.8), CNS E11.5 (RPKM 1.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rpp40 in Genome Data Viewer
Location:
13 A3.3; 13 14.44 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (36080685..36095548, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (35895104..35911565, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34172 Neighboring gene STARR-seq mESC enhancer starr_34173 Neighboring gene predicted gene, 22674 Neighboring gene STARR-seq mESC enhancer starr_34176 Neighboring gene STARR-seq mESC enhancer starr_34177 Neighboring gene predicted gene, 22126 Neighboring gene STARR-seq mESC enhancer starr_34179 Neighboring gene STARR-positive B cell enhancer ABC_E10788 Neighboring gene chromodomain protein, Y chromosome-like Neighboring gene STARR-seq mESC enhancer starr_34180 Neighboring gene STARR-seq mESC enhancer starr_34183 Neighboring gene STARR-seq mESC enhancer starr_34184 Neighboring gene protein phosphatase 1, regulatory subunit 3G Neighboring gene predicted gene, 30127 Neighboring gene transmembrane p24 trafficking protein 10, pseudogene Neighboring gene predicted gene, 18132 Neighboring gene LYR motif containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P. Jarrous N, et al. RNA, 1998 Apr. PMID 9630247, Free PMC Article
  2. Gene structure, tissue expression, and linkage mapping of the mouse DLC-1 gene (Arhgap7). Durkin ME, et al. Gene, 2002 Apr 17. PMID 12034501
  3. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
  4. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC25944

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to ribonuclease MRP activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonuclease P RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables ribonuclease P RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to ribonuclease P activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ribonuclease P activity ISO
Inferred from Sequence Orthology
more info
  
enables ribonuclease P activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
contributes_to ribonuclease P activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA 5'-leader removal IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tRNA 5'-leader removal ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in tRNA 5'-leader removal ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA 5'-leader removal ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of multimeric ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of multimeric ribonuclease P complex ISO
Inferred from Sequence Orthology
more info
  
part_of multimeric ribonuclease P complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of nucleolar ribonuclease P complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of ribonuclease MRP complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ribonuclease P protein subunit p40
Names
RNaseP protein p40
ribonuclease P 40kDa subunit
ribonuclease P1
NP_001413309.1
NP_001413310.1
NP_001413311.1
NP_001413312.1
NP_001413313.1
NP_001413314.1
NP_001413315.1
NP_666050.3
XP_006516694.1
XP_011242604.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001426380.1 → NP_001413309.1  ribonuclease P protein subunit p40 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134860, AC159209

  2. NM_001426381.1 → NP_001413310.1  ribonuclease P protein subunit p40 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC134860, AC159209

  3. NM_001426382.1 → NP_001413311.1  ribonuclease P protein subunit p40 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC134860, AC159209

  4. NM_001426383.1 → NP_001413312.1  ribonuclease P protein subunit p40 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC134860, AC159209

  5. NM_001426384.1 → NP_001413313.1  ribonuclease P protein subunit p40 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC134860, AC159209
    UniProtKB/TrEMBL
    G3UYU5
    Related
    ENSMUSP00000134228.2, ENSMUST00000174230.2

  6. NM_001426385.1 → NP_001413314.1  ribonuclease P protein subunit p40 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC134860, AC159209

  7. NM_001426386.1 → NP_001413315.1  ribonuclease P protein subunit p40 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC134860, AC159209

  8. NM_145938.5 → NP_666050.3  ribonuclease P protein subunit p40 isoform 1

    See identical proteins and their annotated locations for NP_666050.3

    Status: VALIDATED

    Source sequence(s)
    AC134860, AC159209
    Consensus CDS
    CCDS26451.2
    UniProtKB/Swiss-Prot
    Q8BX66, Q8R1F9
    Related
    ENSMUSP00000130290.3, ENSMUST00000171686.9
    Conserved Domains (1) summary
    pfam08584
    Location:75 → 343
    Ribonuc_P_40; Ribonuclease P 40kDa (Rpp40) subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    36080685..36095548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244302.1 → XP_011242604.1  ribonuclease P protein subunit p40 isoform X2

    See identical proteins and their annotated locations for XP_011242604.1

    Conserved Domains (1) summary
    pfam08584
    Location:15 → 282
    Ribonuc_P_40; Ribonuclease P 40kDa (Rpp40) subunit

  2. XM_006516631.4 → XP_006516694.1  ribonuclease P protein subunit p40 isoform X1

    Conserved Domains (1) summary
    pfam08584
    Location:41 → 308
    Ribonuc_P_40; Ribonuclease P 40kDa (Rpp40) subunit
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1F9.2 GenPept UniProtKB/Swiss-Prot:Q8R1F9

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