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Yeats2 YEATS domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 208146, updated on 2-Nov-2024

Summary

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Official Symbol
Yeats2provided by MGI
Official Full Name
YEATS domain containing 2provided by MGI
Primary source
MGI:MGI:2447762
See related
Ensembl:ENSMUSG00000041215 AllianceGenome:MGI:2447762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1197
Summary
Predicted to enable several functions, including TBP-class protein binding activity; histone reader activity; and transcription corepressor activity. Involved in regulation of cell cycle; regulation of cell division; and regulation of embryonic development. Located in mitotic spindle and nucleus. Part of ATAC complex. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 4. Orthologous to human YEATS2 (YEATS domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 38.3), CNS E14 (RPKM 32.8) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Yeats2 in Genome Data Viewer
Location:
16 A3; 16 12.37 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (19959803..20051323)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20141053..20232573)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40308 Neighboring gene kelch-like 6 Neighboring gene STARR-seq mESC enhancer starr_40309 Neighboring gene STARR-positive B cell enhancer ABC_E2456 Neighboring gene STARR-positive B cell enhancer ABC_E1183 Neighboring gene kelch-like 24 Neighboring gene STARR-seq mESC enhancer starr_40314 Neighboring gene SMT3 suppressor of mif two 3 homolog 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40316 Neighboring gene predicted gene, 41431 Neighboring gene MAP6 domain containing 1 Neighboring gene predicted gene, 49566

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Repression of YEATS2 induces cellular senescence in hepatocellular carcinoma and inhibits tumor growth. Wu Q, et al. Cell Cycle, 2024 Feb. PMID 38619971,
  2. The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. Orpinell M, et al. EMBO J, 2010 Jul 21. PMID 20562830, Free PMC Article
  3. The metazoan ATAC and SAGA coactivator HAT complexes regulate different sets of inducible target genes. Nagy Z, et al. Cell Mol Life Sci, 2010 Feb. PMID 19936620, Free PMC Article
  4. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Guelman S, et al. Mol Cell Biol, 2009 Mar. PMID 19103755, Free PMC Article
  5. ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. Krebs AR, et al. EMBO Rep, 2010 Jul. PMID 20508642, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Repression of YEATS2 induces cellular senescence in hepatocellular carcinoma and inhibits tumor growth.
    Title: Repression of YEATS2 induces cellular senescence in hepatocellular carcinoma and inhibits tumor growth.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables TBP-class protein binding IEA
Inferred from Electronic Annotation
more info
  
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone reader activity IEA
Inferred from Electronic Annotation
more info
  
enables histone reader activity ISO
Inferred from Sequence Orthology
more info
  
enables modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables modification-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell division IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell division ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell division ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of embryonic development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of tubulin deacetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of tubulin deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of ATAC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ATAC complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
  
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitotic spindle NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
YEATS domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033237.2 → NP_001028409.2  YEATS domain-containing protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is missing an exon found in transcript variant 1, which results in translation initiation from an in-frame downstream AUG, and an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK160791, BC150944, BU055428, CB182287
    Consensus CDS
    CCDS28043.1
    UniProtKB/TrEMBL
    B9EKJ4
    Related
    ENSMUSP00000087506.5, ENSMUST00000090052.11
    Conserved Domains (2) summary
    PRK07003
    Location:834 → 1070
    PRK07003; DNA polymerase III subunit gamma/tau
    cd16907
    Location:156 → 279
    YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12

  2. NM_001145930.1 → NP_001139402.1  YEATS domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001139402.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK160791, AK165933, BC150944, BU055428, CB182287
    Consensus CDS
    CCDS49790.1
    UniProtKB/Swiss-Prot
    Q3TUF7, Q6PGF8, Q80TI2, Q8CG86
    UniProtKB/TrEMBL
    A0A338P697
    Related
    ENSMUSP00000111222.3, ENSMUST00000115560.4
    Conserved Domains (2) summary
    PRK07003
    Location:887 → 1123
    PRK07003; DNA polymerase III subunit gamma/tau
    cd16907
    Location:209 → 332
    YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12

  3. NM_001145931.1 → NP_001139403.1  YEATS domain-containing protein 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate segment at the 3' end compared to variant 1. This results in a frame-shift and a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AA138143, AC120150, AK165933, BU055428
    Conserved Domains (1) summary
    pfam03366
    Location:232 → 309
    YEATS; YEATS family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    19959803..20051323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521903.4 → XP_006521966.1  YEATS domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A338P697
    Conserved Domains (2) summary
    PRK07003
    Location:884 → 1120
    PRK07003; DNA polymerase III subunit gamma/tau
    cd16907
    Location:206 → 329
    YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12

  2. XM_036159831.1 → XP_036015724.1  YEATS domain-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A338P697
    Conserved Domains (2) summary
    PRK07003
    Location:884 → 1120
    PRK07003; DNA polymerase III subunit gamma/tau
    cd16907
    Location:206 → 329
    YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12

  3. XM_006521904.3 → XP_006521967.1  YEATS domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A338P697
    Conserved Domains (2) summary
    PRK07003
    Location:887 → 1123
    PRK07003; DNA polymerase III subunit gamma/tau
    cd16907
    Location:209 → 332
    YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12

  4. XM_006521905.3 → XP_006521968.1  YEATS domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A338P697
    Conserved Domains (2) summary
    PRK07003
    Location:790 → 1026
    PRK07003; DNA polymerase III subunit gamma/tau
    cd16907
    Location:209 → 332
    YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12

  5. XM_030249018.1 → XP_030104878.1  YEATS domain-containing protein 2 isoform X5

    UniProtKB/TrEMBL
    B9EKJ4
    Related
    ENSMUSP00000155892.2, ENSMUST00000232019.2
    Conserved Domains (2) summary
    PRK07003
    Location:831 → 1067
    PRK07003; DNA polymerase III subunit gamma/tau
    cd16907
    Location:153 → 276
    YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12

  6. XM_006521902.5 → XP_006521965.1  YEATS domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006521965.1

    UniProtKB/Swiss-Prot
    Q3TUF7, Q6PGF8, Q80TI2, Q8CG86
    UniProtKB/TrEMBL
    A0A338P697
    Conserved Domains (2) summary
    PRK07003
    Location:887 → 1123
    PRK07003; DNA polymerase III subunit gamma/tau
    cd16907
    Location:209 → 332
    YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12

  7. XM_030249017.1 → XP_030104877.1  YEATS domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A338P697
    Conserved Domains (2) summary
    PRK07003
    Location:884 → 1120
    PRK07003; DNA polymerase III subunit gamma/tau
    cd16907
    Location:206 → 329
    YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12

  8. XM_036159832.1 → XP_036015725.1  YEATS domain-containing protein 2 isoform X8

    Conserved Domains (1) summary
    PRK07003
    Location:432 → 668
    PRK07003; DNA polymerase III subunit gamma/tau

  9. XM_006521906.5 → XP_006521969.1  YEATS domain-containing protein 2 isoform X7

    UniProtKB/TrEMBL
    B9EKJ4
    Conserved Domains (1) summary
    PRK07003
    Location:619 → 855
    PRK07003; DNA polymerase III subunit gamma/tau

RNA

  1. XR_001781806.3 RNA Sequence

  2. XR_384540.4 RNA Sequence

    Related
    ENSMUST00000232338.2

  3. XR_384538.4 RNA Sequence

  4. XR_004939174.1 RNA Sequence

  5. XR_001781807.2 RNA Sequence

  6. XR_384537.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TUF7.2 GenPept UniProtKB/Swiss-Prot:Q3TUF7

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