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Dtx4 deltex 4, E3 ubiquitin ligase [ Mus musculus (house mouse) ]

Gene ID: 207521, updated on 2-Nov-2024

Summary

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Official Symbol
Dtx4provided by MGI
Official Full Name
deltex 4, E3 ubiquitin ligaseprovided by MGI
Primary source
MGI:MGI:2672905
See related
Ensembl:ENSMUSG00000039982 AllianceGenome:MGI:2672905
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RNF155; D930042H13
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including Notch signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K48-linked ubiquitination. Predicted to be located in cytoplasm. Predicted to be active in centrosome and nucleoplasm. Is expressed in several structures, including central nervous system; genitourinary system; and retina. Orthologous to human DTX4 (deltex E3 ubiquitin ligase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 16.0), CNS E11.5 (RPKM 13.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dtx4 in Genome Data Viewer
Location:
19 A; 19 8.72 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (12443700..12479509, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (12466329..12502179, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene pore forming protein-like Neighboring gene macrophage expressed gene 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:12551432-12551640 Neighboring gene STARR-positive B cell enhancer ABC_E2522 Neighboring gene STARR-seq mESC enhancer starr_45593 Neighboring gene predicted gene, 57827 Neighboring gene family with sequence similarity 111, member A pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr19:12615291-12615592 Neighboring gene STARR-seq mESC enhancer starr_45594 Neighboring gene STARR-seq mESC enhancer starr_45595 Neighboring gene family with sequence similarity 111, member A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. E3 ubiquitin ligase DTX4 is required for adipogenic differentiation in 3T3-L1 preadipocytes cell line. Wang Z, et al. Biochem Biophys Res Commun, 2017 Oct 21. PMID 28842252
  2. Normal immune system development in mice lacking the Deltex-1 RING finger domain. Storck S, et al. Mol Cell Biol, 2005 Feb. PMID 15684394, Free PMC Article
  3. T cells develop normally in the absence of both Deltex1 and Deltex2. Lehar SM, et al. Mol Cell Biol, 2006 Oct. PMID 16923970, Free PMC Article
  4. Identification of molecules preferentially expressed beneath the marginal zone in the developing cerebral cortex. Tachikawa K, et al. Neurosci Res, 2008 Feb. PMID 18055048
  5. Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia. Heng X, et al. Elife, 2017 May 10. PMID 28489004, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase DTX4
Names
RING-type E3 ubiquitin transferase DTX4
deltex 4 homolog
deltex4
protein deltex-4
NP_001388321.1
NP_766030.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401392.1 → NP_001388321.1  E3 ubiquitin-protein ligase DTX4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC151730

  2. NM_172442.3 → NP_766030.3  E3 ubiquitin-protein ligase DTX4 isoform 1

    See identical proteins and their annotated locations for NP_766030.3

    Status: VALIDATED

    Source sequence(s)
    BC058647, BU705490, CA328050, CF537541, CN525673
    Consensus CDS
    CCDS29631.1
    UniProtKB/Swiss-Prot
    Q6IS30, Q6PDK8, Q8BID3
    Related
    ENSMUSP00000040229.8, ENSMUST00000045521.9
    Conserved Domains (4) summary
    smart00678
    Location:8 → 86
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:473 → 605
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd00162
    Location:405 → 466
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam02825
    Location:90 → 144
    WWE; WWE domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    12443700..12479509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PDK8.2 GenPept UniProtKB/Swiss-Prot:Q6PDK8

Gene LinkOut

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