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Strbp spermatid perinuclear RNA binding protein [ Mus musculus (house mouse) ]

Gene ID: 20744, updated on 2-Nov-2024

Summary

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Official Symbol
Strbpprovided by MGI
Official Full Name
spermatid perinuclear RNA binding proteinprovided by MGI
Primary source
MGI:MGI:104626
See related
Ensembl:ENSMUSG00000026915 AllianceGenome:MGI:104626
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Spnr; 6430510M02Rik; C230082I21Rik
Summary
Enables double-stranded RNA binding activity; microtubule binding activity; and single-stranded RNA binding activity. Acts upstream of or within cell motility; mechanosensory behavior; and spermatid development. Located in manchette. Is expressed in central nervous system; dorsal root ganglion; metanephros; sensory organ; and trigeminal nerve. Orthologous to human STRBP (spermatid perinuclear RNA binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in frontal lobe adult (RPKM 9.7), cortex adult (RPKM 9.6) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Strbp in Genome Data Viewer
Location:
2 B; 2 24.19 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (37459880..37593890, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (37569868..37703878, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RAB GTPase activating protein 1 Neighboring gene nucleoporin 37 pseudogene Neighboring gene G protein-coupled receptor 21 Neighboring gene zinc finger protein 609 pseudogene Neighboring gene microRNA 5128 Neighboring gene STARR-positive B cell enhancer ABC_E9511 Neighboring gene STARR-seq mESC enhancer starr_04315 Neighboring gene STARR-positive B cell enhancer ABC_E5909 Neighboring gene DENN domain containing 1A Neighboring gene crumbs family member 2 Neighboring gene STARR-seq mESC enhancer starr_04318 Neighboring gene STARR-seq mESC enhancer starr_04319 Neighboring gene STARR-seq mESC enhancer starr_04321 Neighboring gene predicted gene, 46736 Neighboring gene LIM homeobox protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Spnr, a murine RNA-binding protein that is localized to cytoplasmic microtubules. Schumacher JM, et al. J Cell Biol, 1995 May. PMID 7744952, Free PMC Article
  2. Gene trap expression and mutational analysis for genes involved in the development of the mammalian nervous system. Stoykova A, et al. Dev Dyn, 1998 Jun. PMID 9626495
  3. Mice deficient for spermatid perinuclear RNA-binding protein show neurologic, spermatogenic, and sperm morphological abnormalities. Pires-daSilva A, et al. Dev Biol, 2001 May 15. PMID 11336498
  4. Spermatid perinuclear ribonucleic acid-binding protein binds microtubules in vitro and associates with abnormal manchettes in vivo in mice. Schumacher JM, et al. Biol Reprod, 1998 Jul. PMID 9674995
  5. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mechanosensory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in manchette IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
spermatid perinuclear RNA-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355259.1 → NP_001342188.1  spermatid perinuclear RNA-binding protein isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, 4, and 5 all encode the same isoform (a).
    Source sequence(s)
    AL953890, BX545905
    Consensus CDS
    CCDS38118.1
    UniProtKB/Swiss-Prot
    Q62262, Q91WM1
    Conserved Domains (4) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608 → 667
    SGP; Sulphur globule protein
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  2. NM_001379314.1 → NP_001366243.1  spermatid perinuclear RNA-binding protein isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 1, 2, and 5, encodes isoform a.
    Source sequence(s)
    AL805959, AL953890, BX545905
    UniProtKB/Swiss-Prot
    Q62262, Q91WM1
    Conserved Domains (4) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608 → 667
    SGP; Sulphur globule protein
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  3. NM_001379315.1 → NP_001366244.1  spermatid perinuclear RNA-binding protein isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 1, 2, and 4, encodes isoform a.
    Source sequence(s)
    AL805959, AL953890, BX545905
    UniProtKB/Swiss-Prot
    Q62262, Q91WM1
    Related
    ENSMUSP00000072047.6, ENSMUST00000072186.12
    Conserved Domains (4) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608 → 667
    SGP; Sulphur globule protein
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  4. NM_001379316.1 → NP_001366245.1  spermatid perinuclear RNA-binding protein isoform c

    Status: VALIDATED

    Source sequence(s)
    AL805959, AL953890, BX545905
    Conserved Domains (3) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  5. NM_009261.4 → NP_033287.2  spermatid perinuclear RNA-binding protein isoform a

    See identical proteins and their annotated locations for NP_033287.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 all encode the same isoform (a).
    Source sequence(s)
    AL953890, BX545905
    Consensus CDS
    CCDS38118.1
    UniProtKB/Swiss-Prot
    Q62262, Q91WM1
    Related
    ENSMUSP00000028279.4, ENSMUST00000028279.10
    Conserved Domains (4) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608 → 667
    SGP; Sulphur globule protein
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

RNA

  1. NR_166612.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL953890, BX545905

  2. NR_166614.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL805959, AL953890, BX545905

  3. NR_166615.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL805959, AL953890, BX545905

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    37459880..37593890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160012.1 → XP_036015905.1  spermatid perinuclear RNA-binding protein isoform X1

    Conserved Domains (4) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608 → 664
    SGP; Sulphur globule protein
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  2. XM_036160033.1 → XP_036015926.1  spermatid perinuclear RNA-binding protein isoform X3

    Conserved Domains (3) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  3. XM_036160005.1 → XP_036015898.1  spermatid perinuclear RNA-binding protein isoform X1

    Conserved Domains (4) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608 → 664
    SGP; Sulphur globule protein
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  4. XM_011239043.4 → XP_011237345.1  spermatid perinuclear RNA-binding protein isoform X1

    See identical proteins and their annotated locations for XP_011237345.1

    Conserved Domains (4) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608 → 664
    SGP; Sulphur globule protein
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  5. XM_036160013.1 → XP_036015906.1  spermatid perinuclear RNA-binding protein isoform X1

    Conserved Domains (4) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608 → 664
    SGP; Sulphur globule protein
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  6. XM_036160022.1 → XP_036015915.1  spermatid perinuclear RNA-binding protein isoform X1

    Conserved Domains (4) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608 → 664
    SGP; Sulphur globule protein
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  7. XM_036160018.1 → XP_036015911.1  spermatid perinuclear RNA-binding protein isoform X1

    Conserved Domains (4) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608 → 664
    SGP; Sulphur globule protein
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  8. XM_036160011.1 → XP_036015904.1  spermatid perinuclear RNA-binding protein isoform X1

    Conserved Domains (4) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608 → 664
    SGP; Sulphur globule protein
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  9. XM_036160015.1 → XP_036015908.1  spermatid perinuclear RNA-binding protein isoform X1

    Conserved Domains (4) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608 → 664
    SGP; Sulphur globule protein
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  10. XM_030248990.1 → XP_030104850.1  spermatid perinuclear RNA-binding protein isoform X3

    Related
    ENSMUSP00000139145.2, ENSMUST00000183690.8
    Conserved Domains (3) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  11. XM_017316823.2 → XP_017172312.1  spermatid perinuclear RNA-binding protein isoform X2

    UniProtKB/Swiss-Prot
    Q62262, Q91WM1
    Conserved Domains (4) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608 → 667
    SGP; Sulphur globule protein
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  12. XM_036160024.1 → XP_036015917.1  spermatid perinuclear RNA-binding protein isoform X2

    UniProtKB/Swiss-Prot
    Q62262, Q91WM1
    Conserved Domains (4) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608 → 667
    SGP; Sulphur globule protein
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

  13. XM_017316820.3 → XP_017172309.1  spermatid perinuclear RNA-binding protein isoform X2

    UniProtKB/Swiss-Prot
    Q62262, Q91WM1
    Conserved Domains (4) summary
    smart00572
    Location:81 → 334
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    pfam17228
    Location:608 → 667
    SGP; Sulphur globule protein
    cd19909
    Location:384 → 467
    DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
    cd19911
    Location:512 → 575
    DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

RNA

  1. XR_003951764.1 RNA Sequence

  2. XR_001781603.2 RNA Sequence

  3. XR_866011.3 RNA Sequence

  4. XR_866010.3 RNA Sequence

  5. XR_866009.3 RNA Sequence

  6. XR_001781604.2 RNA Sequence

  7. XR_003951765.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_176932.2: Suppressed sequence

    Description
    NM_176932.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WM1.1 GenPept UniProtKB/Swiss-Prot:Q91WM1

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