Elfn2 leucine rich repeat and fibronectin type III, extracellular 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Elfn2provided by MGI
Official Full Name: leucine rich repeat and fibronectin type III, extracellular 2provided by MGI
Primary source: MGI:MGI:3608416
See related: Ensembl:ENSMUSG00000043460 AllianceGenome:MGI:3608416
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lrrc62; Ppp1r29; 6330514E13
Summary: Predicted to enable protein phosphatase inhibitor activity. Involved in synaptic membrane adhesion. Acts upstream of or within chemical synaptic transmission; establishment of protein localization; and gene expression. Is active in postsynaptic density membrane. Is expressed in eye; intestine; male reproductive gland or organ; and nervous system. Orthologous to human ELFN2 (extracellular leucine rich repeat and fibronectin type III domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in frontal lobe adult (RPKM 10.4), testis adult (RPKM 9.5) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 37.64 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (78551531..78603056, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (78667333..78718771, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Complex N-glycosylation of mGluR6 is required for trans-synaptic interaction with ELFN adhesion proteins.
Title: Complex N-glycosylation of mGluR6 is required for trans-synaptic interaction with ELFN adhesion proteins.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D15Mit1 (e-PCR), detects polymorphism
- UniSTS:127458

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chemical synaptic transmission	IGI Inferred from Genetic Interaction more info
acts_upstream_of_or_within chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within establishment of protein localization	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info
involved_in synaptic membrane adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic membrane adhesion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IEP Inferred from Expression Pattern more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein phosphatase 1 regulatory subunit 29

Names: 5leucine rich repeat containing 62; extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2; leucine rich repeat containing 62; leucine-rich repeat and fibronectin type-III domain-containing protein 6; leucine-rich repeat-containing protein 62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358692.2 → NP_001345621.1 protein phosphatase 1 regulatory subunit 29 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AL591946

Consensus CDS

CCDS27621.1

UniProtKB/Swiss-Prot

Q68FM6, Q69Z72, Q8CCW8

Related

ENSMUSP00000085960.5, ENSMUST00000088592.6

Conserved Domains (4) summary

TIGR00864
Location:157 → 227

PCC; polycystin cation channel protein

sd00031
Location:60 → 80

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:200 → 226

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:80 → 139

LRR_8; Leucine rich repeat
NM_001416409.1 → NP_001403338.1 protein phosphatase 1 regulatory subunit 29 precursor

Status: VALIDATED

Source sequence(s)

AL591946

UniProtKB/Swiss-Prot

Q68FM6, Q69Z72, Q8CCW8
NM_183141.3 → NP_898964.2 protein phosphatase 1 regulatory subunit 29 precursor

See identical proteins and their annotated locations for NP_898964.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AL591946

Consensus CDS

CCDS27621.1

UniProtKB/Swiss-Prot

Q68FM6, Q69Z72, Q8CCW8

Related

ENSMUSP00000155111.2, ENSMUST00000229441.2

Conserved Domains (4) summary

TIGR00864
Location:157 → 227

PCC; polycystin cation channel protein

sd00031
Location:60 → 80

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:200 → 226

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:80 → 139

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

78551531..78603056 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159292.1 → XP_036015185.1 protein phosphatase 1 regulatory subunit 29 isoform X1

UniProtKB/Swiss-Prot

Q68FM6, Q69Z72, Q8CCW8

Conserved Domains (4) summary

TIGR00864
Location:157 → 227

PCC; polycystin cation channel protein

sd00031
Location:60 → 80

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:200 → 226

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:80 → 139

LRR_8; Leucine rich repeat
XM_036159290.1 → XP_036015183.1 protein phosphatase 1 regulatory subunit 29 isoform X1

UniProtKB/Swiss-Prot

Q68FM6, Q69Z72, Q8CCW8

Conserved Domains (4) summary

TIGR00864
Location:157 → 227

PCC; polycystin cation channel protein

sd00031
Location:60 → 80

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:200 → 226

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:80 → 139

LRR_8; Leucine rich repeat