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Sec23ip Sec23 interacting protein [ Mus musculus (house mouse) ]

Gene ID: 207352, updated on 2-Nov-2024

Summary

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Official Symbol
Sec23ipprovided by MGI
Official Full Name
Sec23 interacting proteinprovided by MGI
Primary source
MGI:MGI:2450915
See related
Ensembl:ENSMUSG00000055319 AllianceGenome:MGI:2450915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p125; D7Ertd373e
Summary
Predicted to enable metal ion binding activity. Acts upstream of or within acrosome assembly and single fertilization. Located in cis-Golgi network; endoplasmic reticulum exit site; and perinuclear endoplasmic reticulum. Orthologous to human SEC23IP (SEC23 interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 24.2), thymus adult (RPKM 11.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Sec23ip in Genome Data Viewer
Location:
7 F3; 7 70.51 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (128346667..128386560)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (128744862..128784836)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate-5-phosphatase F Neighboring gene pentatricopeptide repeat domain 3 pseudogene Neighboring gene minichromosome maintenance complex binding protein Neighboring gene STARR-positive B cell enhancer ABC_E3757 Neighboring gene STARR-seq mESC enhancer starr_20212 Neighboring gene STARR-seq mESC enhancer starr_20213 Neighboring gene STARR-seq mESC enhancer starr_20214 Neighboring gene predicted gene, 39093 Neighboring gene predicted gene, 32884 Neighboring gene STARR-seq mESC enhancer starr_20215

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of Sec23ip, Part of 14-3-3γ Protein Network, as a Regulator of Acute Steroidogenesis in MA-10 Leydig Cells. Aghazadeh Y, et al. Endocrinology, 2020 Feb 1. PMID 31875919, Free PMC Article
  2. p125/Sec23-interacting protein (Sec23ip) is required for spermiogenesis. Arimitsu N, et al. FEBS Lett, 2011 Jul 21. PMID 21640725
  3. DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis. Li Y, et al. Blood, 2021 Dec 9. PMID 34255829, Free PMC Article
  4. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
  5. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. involved in cholesterol trafficking to supply cholesterol for acute steroidogenesis through its interactions with 14-3-3gamma
    Title: Identification of Sec23ip, Part of 14-3-3γ Protein Network, as a Regulator of Acute Steroidogenesis in MA-10 Leydig Cells.
  2. These results suggest that p125/Sec23-interacting protein plays an important role in spermiogenesis.
    Title: p125/Sec23-interacting protein (Sec23ip) is required for spermiogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within acrosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within single fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ER to Golgi transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cis-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum exit site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SEC23-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029982.3 → NP_001025153.2  SEC23-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_001025153.2

    Status: VALIDATED

    Source sequence(s)
    AC136741
    Consensus CDS
    CCDS21900.1
    UniProtKB/TrEMBL
    G3X928, Q4G0C0
    Related
    ENSMUSP00000035610.9, ENSMUST00000042942.10
    Conserved Domains (3) summary
    smart00454
    Location:649 → 700
    SAM; Sterile alpha motif
    pfam02862
    Location:780 → 986
    DDHD; DDHD domain
    cl15755
    Location:634 → 702
    SAM_superfamily; SAM (Sterile alpha motif )

  2. NM_001420513.1 → NP_001407442.1  SEC23-interacting protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC136741

  3. NM_001420514.1 → NP_001407443.1  SEC23-interacting protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC136741

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    128346667..128386560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NZC7.2 GenPept UniProtKB/Swiss-Prot:Q6NZC7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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