Spic Spi-C transcription factor (Spi-1/PU.1 related) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spicprovided by MGI
Official Full Name: Spi-C transcription factor (Spi-1/PU.1 related)provided by MGI
Primary source: MGI:MGI:1341168
See related: Ensembl:ENSMUSG00000004359 AllianceGenome:MGI:1341168
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Prf; Spi-C
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within blastocyst development. Predicted to be active in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system; liver; and nervous system. Orthologous to human SPIC (Spi-C transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver E18 (RPKM 5.0), spleen adult (RPKM 4.5) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 44.14 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (88511131..88518885, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (88675269..88683023, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spic regulates one-carbon metabolism and histone methylation in ground-state pluripotency.
Title: Spic regulates one-carbon metabolism and histone methylation in ground-state pluripotency.
Spi-C and PU.1 Counterregulate Rag1 and Igkappa Transcription to Effect Vkappa-Jkappa Recombination in Small Pre-B Cells.
Title: Spi-C and PU.1 Counterregulate Rag1 and Igκ Transcription to Effect Vκ-Jκ Recombination in Small Pre-B Cells.
Counter Regulation of Spic by NF-kappaB and STAT Signaling Controls Inflammation and Iron Metabolism in Macrophages.
Title: Counter Regulation of Spic by NF-κB and STAT Signaling Controls Inflammation and Iron Metabolism in Macrophages.
Opposing Roles for the Related ETS-Family Transcription Factors Spi-B and Spi-C in Regulating B Cell Differentiation and Function.
Title: Opposing Roles for the Related ETS-Family Transcription Factors Spi-B and Spi-C in Regulating B Cell Differentiation and Function.
RAG-Mediated DNA Breaks Attenuate PU.1 Activity in Early B Cells through Activation of a SPIC-BCLAF1 Complex.
Title: RAG-Mediated DNA Breaks Attenuate PU.1 Activity in Early B Cells through Activation of a SPIC-BCLAF1 Complex.
Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C.
Title: Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C.
These results indicate a novel role for Spi-C as a negative regulator of B cell development and function.
Title: Identification of a negative regulatory role for spi-C in the murine B cell lineage.
Study reports that Spic regulated the development of F4/80(+)VCAM1(+) bone marrow macrophages (BMM) and that Spic expression in BMM and red pulp macrophages development was induced by heme, a metabolite of erythrocyte degradation.
Title: Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages.
Regulation of follicular B cell differentiation by the related E26 transformation-specific transcription factors PU.1, Spi-B, and Spi-C.
Title: Regulation of follicular B cell differentiation by the related E26 transformation-specific transcription factors PU.1, Spi-B, and Spi-C.
Spi-C controls development of red pulp macrophages required for red blood cell recycling and iron homeostasis
Title: Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Spic (e-PCR), detects polymorphism
- UniSTS:547373

RH136540 (e-PCR)
- UniSTS:210522

RH126036 (e-PCR)
- UniSTS:162748

Spic (e-PCR), detects polymorphism
- UniSTS:536552

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor Spi-C

Names: pu.1-related factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.