Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpine2provided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade E, member 2provided by MGI
Primary source: MGI:MGI:101780
See related: Ensembl:ENSMUSG00000026249 AllianceGenome:MGI:101780
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PI7; PI-7; PN-1; Spi4; PAI-1; B230326M24Rik
Summary: Enables serine-type endopeptidase inhibitor activity and signaling receptor binding activity. Involved in negative regulation of plasminogen activation and negative regulation of platelet aggregation. Acts upstream of or within several processes, including modulation of chemical synaptic transmission; negative regulation of protein metabolic process; and negative regulation of signal transduction. Located in extracellular region and neuromuscular junction. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; musculoskeletal system; and reproductive system. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SERPINE2 (serpin family E member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in ovary adult (RPKM 75.8), frontal lobe adult (RPKM 44.2) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C4; 1 40.97 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (79772038..79836382, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (79794317..79858665, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Serpin E2 alters antimicrobial gene expression by microglia but not astrocytes.
Title: Loss of Serpin E2 alters antimicrobial gene expression by microglia but not astrocytes.
NFAT5 directs hyperosmotic stress-induced fibrin deposition and macrophage infiltration via PAI-1 in endothelium.
Title: NFAT5 directs hyperosmotic stress-induced fibrin deposition and macrophage infiltration via PAI-1 in endothelium.
Development and characterization of single-domain antibodies neutralizing protease nexin-1 as tools to increase thrombin generation.
Title: Development and characterization of single-domain antibodies neutralizing protease nexin-1 as tools to increase thrombin generation.
Findings provide support that PAI-1 contributes to the development of inflammation in perirenal fat and correlates with the development of diabetic nephropathy in high fat diet-induced obesity.
Title: Inhibition of PAI-1 attenuates perirenal fat inflammation and the associated nephropathy in high-fat diet-induced obese mice.
These data demonstrate that prevention of thrombin signaling by PN-1 constitutes an important endogenous mechanism of protection against lung fibrosis and associated mortality.
Title: Hematopoietic protease nexin-1 protects against lung injury by preventing thrombin signaling in mice.
PN-1 and PEDF share structural and functional features, and expression patterns in the retina.
Title: Comparison of two neurotrophic serpins reveals a small fragment with cell survival activity.
SerpinE2 is required in the extracellular milieu of breast tumors where it acts in multiple ways to regulate tumor matrix deposition, thereby controlling tumor cell dissemination.
Title: Serpin E2 promotes breast cancer metastasis by remodeling the tumor matrix and polarizing tumor associated macrophages.
These data uncover a novel mechanism whereby loss of serine protease inhibition leads to lung lymphocyte accumulation.
Title: Serpine2 deficiency results in lung lymphocyte accumulation and bronchus-associated lymphoid tissue formation.
the involvement of PAI-1 in HIF-1-enhanced thrombosis and that an additional factor participates in regulating Pai-1 expression in compressed skin.
Title: Compression-induced HIF-1 enhances thrombosis and PAI-1 expression in mouse skin.
aberrant Serpine2/Pn-1 is required for proliferation of human and mouse medulloblastoma cells.
Title: Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Mit216 (e-PCR), detects polymorphism
- UniSTS:128558

Serpine2 (e-PCR), detects polymorphism
- UniSTS:464691

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glycosaminoglycan binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IGI Inferred from Genetic Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood coagulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebellar granular layer morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dense core granule biogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within innervation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mating plug formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of peptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of plasminogen activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of plasminogen activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of plasminogen activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of platelet activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of platelet activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of platelet aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein processing	IC Inferred by Curator more info	PubMed
involved_in negative regulation of proteolysis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of sodium ion transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of platelet activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of astrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of timing of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within secretion by cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within secretion by cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within secretory granule organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within secretory granule organization	ISO Inferred from Sequence Orthology more info
involved_in secretory granule organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within seminal vesicle epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in platelet alpha granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glia-derived nexin

Names: GDN; peptidase inhibitor 7; protease nexin 1; protease nexin I; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; serine (or cysteine) proteinase inhibitor, clade E, member 2; serine protease-inhibitor 4; serpin E2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.