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Serpinb6b serine (or cysteine) peptidase inhibitor, clade B, member 6b [ Mus musculus (house mouse) ]

Gene ID: 20708, updated on 2-Nov-2024

Summary

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Official Symbol
Serpinb6bprovided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade B, member 6bprovided by MGI
Primary source
MGI:MGI:894688
See related
Ensembl:ENSMUSG00000042842 AllianceGenome:MGI:894688
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NK13; Spi12; ovalbumin
Summary
Predicted to enable protease binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in cellular response to osmotic stress; negative regulation of endopeptidase activity; and sensory perception of sound. Predicted to be part of serine protease inhibitor complex. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including alimentary system; eye surface region; gonad; lung; and submandibular gland primordium. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 91. Orthologous to human SERPINB6 (serpin family B member 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in placenta adult (RPKM 59.9), lung adult (RPKM 11.5) and 5 other tissues See more
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Genomic context

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See Serpinb6b in Genome Data Viewer
Location:
13 A3.2; 13 13.78 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (33140797..33163050)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (32956811..32979067)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene nonconserved acetylation island sequence M71 enhancer Neighboring gene predicted gene, 35899 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 1c Neighboring gene STARR-positive B cell enhancer ABC_E7220 Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_34105 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:33096570-33096679 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 9 Neighboring gene predicted gene, 36181 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 9b Neighboring gene predicted gene, 36099

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Bmp2 regulates Serpinb6b expression via cAMP/PKA/Wnt4 pathway during uterine decidualization. Yu HF, et al. J Cell Mol Med, 2020 Jun. PMID 32391984, Free PMC Article
  2. Identification of Serpinb6b as a species-specific mouse granzyme A inhibitor suggests functional divergence between human and mouse granzyme A. Kaiserman D, et al. J Biol Chem, 2014 Mar 28. PMID 24505135, Free PMC Article
  3. Enhanced egg-induced immunopathology correlates with high IFN-gamma in murine schistosomiasis: identification of two epistatic genetic intervals. Rutitzky LI, et al. J Immunol, 2005 Jan 1. PMID 15611268
  4. Expression of serpinb6 serpins in germ and somatic cells of mouse gonads. Charron Y, et al. Mol Reprod Dev, 2006 Jan. PMID 16175637
  5. A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9). Sun J, et al. J Biol Chem, 1997 Jun 13. PMID 9182575

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bmp2 regulates Serpinb6b expression via cAMP/PKA/Wnt4 pathway during uterine decidualization.
    Title: Bmp2 regulates Serpinb6b expression via cAMP/PKA/Wnt4 pathway during uterine decidualization.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to osmotic stress ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of serine protease inhibitor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine (or cysteine) proteinase inhibitor, clade B, member 6b
Names
serine protease inhibitor 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011454.2 → NP_035584.1  serine (or cysteine) proteinase inhibitor, clade B, member 6b

    See identical proteins and their annotated locations for NP_035584.1

    Status: VALIDATED

    Source sequence(s)
    AI448094, BB065179, DV058071, U96707
    Consensus CDS
    CCDS26430.1
    UniProtKB/TrEMBL
    O08804
    Related
    ENSMUSP00000105922.3, ENSMUST00000110293.9
    Conserved Domains (1) summary
    cl38926
    Location:1 → 377
    serpin; SERine Proteinase INhibitors (serpin) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    33140797..33163050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516621.5 → XP_006516684.1  serine (or cysteine) proteinase inhibitor, clade B, member 6b isoform X1

    See identical proteins and their annotated locations for XP_006516684.1

    UniProtKB/TrEMBL
    O08804
    Conserved Domains (1) summary
    cl38926
    Location:1 → 377
    serpin; SERine Proteinase INhibitors (serpin) family

  2. XM_006516622.5 → XP_006516685.3  serine (or cysteine) proteinase inhibitor, clade B, member 6b isoform X2

    Conserved Domains (1) summary
    cl38926
    Location:44 → 366
    serpin; SERine Proteinase INhibitors (serpin) family
Nucleotide Protein Strain
Heading Accession and Version

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