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Sntb2 syntrophin, basic 2 [ Mus musculus (house mouse) ]

Gene ID: 20650, updated on 2-Nov-2024

Summary

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Official Symbol
Sntb2provided by MGI
Official Full Name
syntrophin, basic 2provided by MGI
Primary source
MGI:MGI:101771
See related
Ensembl:ENSMUSG00000041308 AllianceGenome:MGI:101771
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SNT3; SNTL; Snt2
Summary
Predicted to enable actin binding activity; calmodulin binding activity; and structural molecule activity. Located in synapse. Orthologous to human SNTB2 (syntrophin beta 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in ovary adult (RPKM 9.9), testis adult (RPKM 7.1) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Sntb2 in Genome Data Viewer
Location:
8 D3; 8 53.38 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (107662372..107740864)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (106935740..107014232)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22583 Neighboring gene UTP4 small subunit processome component Neighboring gene ribosomal protein L10, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_22588 Neighboring gene STARR-seq mESC enhancer starr_22589 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:109526496-109526679 Neighboring gene predicted gene, 22085 Neighboring gene STARR-positive B cell enhancer ABC_E3803 Neighboring gene predicted gene 16208 Neighboring gene vacuolar protein sorting 4A Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lower adiposity does not protect beta-2 syntrophin null mice from hepatic steatosis and inflammation in experimental non-alcoholic steatohepatitis. Rein-Fischboeck L, et al. Gene, 2023 Apr 5. PMID 36681100
  2. Structural abnormalities at neuromuscular synapses lacking multiple syntrophin isoforms. Adams ME, et al. J Neurosci, 2004 Nov 17. PMID 15548643, Free PMC Article
  3. Overexpression of c-myc in diabetic mice restores altered expression of the transcription factor genes that regulate liver metabolism. Riu E, et al. Biochem J, 2002 Dec 15. PMID 12230428, Free PMC Article
  4. Two forms of mouse syntrophin, a 58 kd dystrophin-associated protein, differ in primary structure and tissue distribution. Adams ME, et al. Neuron, 1993 Sep. PMID 7691103
  5. Morphological changes and spatial regulation of diacylglycerol kinase-zeta, syntrophins, and Rac1 during myoblast fusion. Abramovici H, et al. Cell Motil Cytoskeleton, 2007 Jul. PMID 17410543

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Current study shows that high SNTB2 in obese adipose tissues restricts adipocyte growth and thereby may contribute to metabolic diseases.
    Title: Adipocyte Hypertrophy and Improved Postprandial Lipid Response in Beta 2 Syntrophin Deficient Mice.
  2. Suggest alpha/beta2-syntrophins do not regulate ABCA1 activity and insulin release but may have a role in regulating glucose uptake, ERK and SR-BI levels, and sphingomyelin metabolism in obesity.
    Title: Lipid abnormalities in alpha/beta2-syntrophin null mice are independent from ABCA1.
  3. ICA512-CCF also dimerizes with intact ICA512 on granules, thereby displacing it from beta2-syntrophin.
    Title: Regulation of insulin granule turnover in pancreatic beta-cells by cleaved ICA512.
  4. Results suggest DGK-zeta and syntrophins play a role at multiple stages of the fusion process.
    Title: Morphological changes and spatial regulation of diacylglycerol kinase-zeta, syntrophins, and Rac1 during myoblast fusion.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of dystrophin-associated glycoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-2-syntrophin
Names
59 kDa dystrophin-associated protein A1 basic component 2
syntrophin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368316.1 → NP_001355245.1  beta-2-syntrophin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123864, AC123868
    Consensus CDS
    CCDS90456.1
    UniProtKB/TrEMBL
    B7ZNU9, Q3V2N5
    Related
    ENSMUSP00000037324.5, ENSMUST00000047425.5

  2. NM_009229.5 → NP_033255.1  beta-2-syntrophin isoform 2

    See identical proteins and their annotated locations for NP_033255.1

    Status: VALIDATED

    Source sequence(s)
    AC123864, AC123868
    Consensus CDS
    CCDS22642.1
    UniProtKB/Swiss-Prot
    Q61235
    UniProtKB/TrEMBL
    Q3V2N5, Q542S9
    Related
    ENSMUSP00000148684.2, ENSMUST00000212524.2
    Conserved Domains (4) summary
    smart00233
    Location:317 → 417
    PH; Pleckstrin homology domain
    cd00992
    Location:93 → 175
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01258
    Location:224 → 281
    PHsplit_syntrophin; Syntrophin Split Pleckstrin homology (PH) domain
    pfam00169
    Location:306 → 417
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    107662372..107740864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61235.2 GenPept UniProtKB/Swiss-Prot:Q61235

Gene LinkOut

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