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Srsf3 serine and arginine-rich splicing factor 3 [ Mus musculus (house mouse) ]

Gene ID: 20383, updated on 2-Nov-2024

Summary

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Official Symbol
Srsf3provided by MGI
Official Full Name
serine and arginine-rich splicing factor 3provided by MGI
Primary source
MGI:MGI:98285
See related
Ensembl:ENSMUSG00000071172 AllianceGenome:MGI:98285
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
X16; Sfrs3
Summary
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
Expression
Broad expression in CNS E11.5 (RPKM 128.5), CNS E14 (RPKM 91.1) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Srsf3 in Genome Data Viewer
Location:
17 A3.3; 17 15.03 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (29251634..29262346)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (29032660..29043372)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 38 Neighboring gene predicted gene, 23887 Neighboring gene STARR-seq mESC enhancer starr_42244 Neighboring gene STARR-seq mESC enhancer starr_42246 Neighboring gene predicted gene 16196 Neighboring gene STARR-seq mESC enhancer starr_42249 Neighboring gene STARR-seq mESC enhancer starr_42251 Neighboring gene tumor protein p53 pathway corepressor 1 Neighboring gene predicted gene, 41556 Neighboring gene STARR-seq mESC enhancer starr_42255 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:29218945-29219128 Neighboring gene STARR-seq mESC enhancer starr_42257 Neighboring gene STARR-seq mESC enhancer starr_42258 Neighboring gene cyclin dependent kinase inhibitor 1A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cardiomyocyte-specific Srsf3 deletion reveals a mitochondrial regulatory role. Dumont AA, et al. FASEB J, 2021 May. PMID 33819356
  2. Diverging mRNA and Protein Networks in Activated Microglia Reveal SRSF3 Suppresses Translation of Highly Upregulated Innate Immune Transcripts. Boutej H, et al. Cell Rep, 2017 Dec 12. PMID 29241548
  3. Adapted Resistance to the Knockdown Effect of shRNA-Derived Srsf3 siRNAs in Mouse Littermates. Ajiro M, et al. Int J Biol Sci, 2015. PMID 26435690, Free PMC Article
  4. Degradation of splicing factor SRSF3 contributes to progressive liver disease. Kumar D, et al. J Clin Invest, 2019 Aug 8. PMID 31393851, Free PMC Article
  5. The RNA-binding protein SRSF3 has an essential role in megakaryocyte maturation and platelet production. Heazlewood SY, et al. Blood, 2022 Mar 3. PMID 34852174, Free PMC Article

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Restoring SRSF3 in Kupffer cells attenuates obesity-related insulin resistance.
    Title: Restoring SRSF3 in Kupffer cells attenuates obesity-related insulin resistance.
  2. Serine and Arginine-Rich Splicing Factor 3 Promotes the Activation of Quiescent Mouse Neural Stem Cells.
    Title: Serine and Arginine-Rich Splicing Factor 3 Promotes the Activation of Quiescent Mouse Neural Stem Cells.
  3. LincRNA-EPS Alleviates Inflammation in TMJ Osteoarthritis by Binding to SRSF3.
    Title: LincRNA-EPS Alleviates Inflammation in TMJ Osteoarthritis by Binding to SRSF3.
  4. Hepatocyte Deletion of IGF2 Prevents DNA Damage and Tumor Formation in Hepatocellular Carcinoma.
    Title: Hepatocyte Deletion of IGF2 Prevents DNA Damage and Tumor Formation in Hepatocellular Carcinoma.
  5. hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells.
    Title: hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells.
  6. The RNA-binding protein SRSF3 has an essential role in megakaryocyte maturation and platelet production.
    Title: The RNA-binding protein SRSF3 has an essential role in megakaryocyte maturation and platelet production.
  7. SRSF3 and SRSF7 modulate 3'UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels.
    Title: SRSF3 and SRSF7 modulate 3'UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels.
  8. Regulated splicing of large exons is linked to phase-separation of vertebrate transcription factors.
    Title: Regulated splicing of large exons is linked to phase-separation of vertebrate transcription factors.
  9. Srsf3 mediates alternative RNA splicing downstream of PDGFRalpha signaling in the facial mesenchyme.
    Title: Srsf3 mediates alternative RNA splicing downstream of PDGFRα signaling in the facial mesenchyme.
  10. Cardiomyocyte-specific Srsf3 deletion reveals a mitochondrial regulatory role.
    Title: Cardiomyocyte-specific Srsf3 deletion reveals a mitochondrial regulatory role.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables phospholipase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables primary miRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables primary miRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-RNA sequence-specific adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-RNA sequence-specific adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sequence-specific mRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA splicing TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in insulin receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in primary miRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in primary miRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/arginine-rich splicing factor 3
Names
pre-mRNA-splicing factor SRP20
splicing factor, arginine/serine-rich 3 (SRp20)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013663.6 → NP_038691.1  serine/arginine-rich splicing factor 3

    See identical proteins and their annotated locations for NP_038691.1

    Status: REVIEWED

    Source sequence(s)
    AC167363
    Consensus CDS
    CCDS28590.1
    UniProtKB/Swiss-Prot
    P84104, Q564E9
    Related
    ENSMUSP00000117045.2, ENSMUST00000130216.3
    Conserved Domains (1) summary
    cd12645
    Location:6 → 86
    RRM_SRSF3; RNA recognition motif (RRM) found in vertebrate serine/arginine-rich splicing factor 3 (SRSF3)

RNA

  1. NR_036613.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC167363
    Related
    ENSMUST00000037776.16

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    29251634..29262346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P84104.1 GenPept UniProtKB/Swiss-Prot:P84104

Gene LinkOut

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