Sfrp4 secreted frizzled-related protein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sfrp4provided by MGI
Official Full Name: secreted frizzled-related protein 4provided by MGI
Primary source: MGI:MGI:892010
See related: Ensembl:ENSMUSG00000021319 AllianceGenome:MGI:892010
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable Wnt-protein binding activity. Involved in bone morphogenesis; negative regulation of Wnt signaling pathway; and regulation of BMP signaling pathway. Predicted to be located in cell surface and nucleus. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including alimentary system; brain; eye; lung; and urinary system. Human ortholog(s) of this gene implicated in metaphyseal dysplasia. Orthologous to human SFRP4 (secreted frizzled related protein 4). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in ovary adult (RPKM 372.4) and subcutaneous fat pad adult (RPKM 17.6) See more
Orthologs: human all
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Genomic context

Location:: 13 A2; 13 6.99 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (19807345..19816995)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (19623175..19632825)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

JMJD2A mediates transcriptional activation of SFRP4 and regulates oxidative stress and mitochondrial dysfunction in heart failure.
Title: JMJD2A mediates transcriptional activation of SFRP4 and regulates oxidative stress and mitochondrial dysfunction in heart failure.
Sfrp4 is required to maintain Ctsk-lineage periosteal stem cell niche function.
Title: Sfrp4 is required to maintain Ctsk-lineage periosteal stem cell niche function.
Downregulation of senescence-associated secretory phenotype by knockdown of secreted frizzled-related protein 4 contributes to the prevention of skin aging.
Title: Downregulation of senescence-associated secretory phenotype by knockdown of secreted frizzled-related protein 4 contributes to the prevention of skin aging.
Secreted frizzled-related protein 4 exerts anti-atherosclerotic effects by reducing inflammation and oxidative stress.
Title: Secreted frizzled-related protein 4 exerts anti-atherosclerotic effects by reducing inflammation and oxidative stress.
Effects of SFRP4 overexpression on the production of adipokines in transgenic mice.
Title: Effects of SFRP4 overexpression on the production of adipokines in transgenic mice.
The adipokine sFRP4 induces insulin resistance and lipogenesis in the liver.
Title: The adipokine sFRP4 induces insulin resistance and lipogenesis in the liver.
these data show autocrine and paracrine effects of Sfrp4 in regulating osteoclast (OC) genesis and demonstrate that the increase in endosteal OCs seen in Sfrp4 (-/-) mice is a consequence of noncanonical Wnt/Ror2/Jnk signaling activation in OCs overriding the negative effect that activation of canonical Wnt/beta-catenin signaling has on OC genesis
Title: Sfrp4 repression of the Ror2/Jnk cascade in osteoclasts protects cortical bone from excessive endosteal resorption.
miR-943-3p accelerated the progression of airway inflammation and remodeling in allergic asthma via suppressing the activity of SFRP4 through Wnt signaling pathway in asthma patients and OVA-induced mice.
Title: Interference of miR-943-3p with secreted frizzled-related proteins4 (SFRP4) in an asthma mouse model.
Knockdown of Sfrp4 in myocardium attenuated myocardial ischemia and reperfusion injury by AKT signaling pathway.
Title: Knockdown of Sfrp4 attenuates apoptosis to protect against myocardial ischemia/reperfusion injury.
Taken together, our results suggest that SFRP4 acts to attenuate granulosa cell responsiveness to gonadotropins, thereby decreasing follicle survival, ovulatory rate, and fertility.
Title: SFRP4 Is a Negative Regulator of Ovarian Follicle Development and Female Fertility.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sfrp4 (e-PCR), detects polymorphism
- UniSTS:527126

Sfrp4 (e-PCR), detects polymorphism
- UniSTS:471845

D13Mit218 (e-PCR), detects polymorphism
- UniSTS:127033

Sfrp4 (e-PCR), detects polymorphism
- UniSTS:507220

Sfrp4 (e-PCR), detects polymorphism
- UniSTS:226199

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in bone morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of non-canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of sodium-dependent phosphate transport	ISO Inferred from Sequence Orthology more info
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: secreted frizzled-related sequence protein 4

Names: FRP-4; frizzled-related protein 4; sFRP-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016687.3 → NP_057896.1 secreted frizzled-related sequence protein 4 precursor

See identical proteins and their annotated locations for NP_057896.1

Status: VALIDATED

Source sequence(s)

AK080766, BC034853

Consensus CDS

CCDS26261.1

UniProtKB/Swiss-Prot

Q91ZX9, Q9Z1N6

Related

ENSMUSP00000002883.6, ENSMUST00000002883.7

Conserved Domains (2) summary

cl02447
Location:20 → 146

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

cl02512
Location:188 → 296

NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...