Selplg selectin, platelet (p-selectin) ligand [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Selplgprovided by MGI
Official Full Name: selectin, platelet (p-selectin) ligandprovided by MGI
Primary source: MGI:MGI:106689
See related: Ensembl:ENSMUSG00000048163 AllianceGenome:MGI:106689
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD162; Psgl1; Selp1; Selpl; Psgl-1
Summary: Involved in leukocyte adhesive activation. Acts upstream of or within leukocyte tethering or rolling. Predicted to be located in plasma membrane raft and uropod. Predicted to be active in plasma membrane. Is expressed in brain and thymus primordium. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human SELPLG (selectin P ligand). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in thymus adult (RPKM 159.7), spleen adult (RPKM 93.8) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 55.59 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (113955859..113970576, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (113817798..113832528, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PSGL-1 is an evolutionarily conserved antiviral restriction factor.
Title: PSGL-1 is an evolutionarily conserved antiviral restriction factor.
B-cell receptor associated protein 31 deficiency decreases the expression of adhesion molecule CD11b/CD18 and PSGL-1 in neutrophils to ameliorate acute lung injury.
Title: B-cell receptor associated protein 31 deficiency decreases the expression of adhesion molecule CD11b/CD18 and PSGL-1 in neutrophils to ameliorate acute lung injury.
High expression of P-selectin induces neutrophil extracellular traps via the PSGL-1/Syk/Ca[2+]/PAD4 pathway to exacerbate acute pancreatitis.
Title: High expression of P-selectin induces neutrophil extracellular traps via the PSGL-1/Syk/Ca(2+)/PAD4 pathway to exacerbate acute pancreatitis.
Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation.
Title: Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation.
Targeted nanotherapy with everolimus reduces inflammation and fibrosis in scleroderma-related interstitial lung disease developed by PSGL-1 deficient mice.
Title: Targeted nanotherapy with everolimus reduces inflammation and fibrosis in scleroderma-related interstitial lung disease developed by PSGL-1 deficient mice.
P-Selectin Glycoprotein Ligand-1 Deficiency Protects Against Aortic Aneurysm Formation Induced by DOCA Plus Salt.
Title: P-Selectin Glycoprotein Ligand-1 Deficiency Protects Against Aortic Aneurysm Formation Induced by DOCA Plus Salt.
P-selectin deficiency promotes liver senescence in sickle cell disease mice.
Title: P-selectin deficiency promotes liver senescence in sickle cell disease mice.
Myeloid Mineralocorticoid Receptor Transcriptionally Regulates P-Selectin Glycoprotein Ligand-1 and Promotes Monocyte Trafficking and Atherosclerosis.
Title: Myeloid Mineralocorticoid Receptor Transcriptionally Regulates P-Selectin Glycoprotein Ligand-1 and Promotes Monocyte Trafficking and Atherosclerosis.
PSGL-1 Is a T Cell Intrinsic Inhibitor That Regulates Effector and Memory Differentiation and Responses During Viral Infection.
Title: PSGL-1 Is a T Cell Intrinsic Inhibitor That Regulates Effector and Memory Differentiation and Responses During Viral Infection.
Relevance of PSGL-1 Expression in B Cell Development and Activation.
Title: Relevance of PSGL-1 Expression in B Cell Development and Activation.

Submit: New GeneRIF Correction See all GeneRIFs (107)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8)
Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in leukocyte adhesive activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in leukocyte tethering or rolling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within leukocyte tethering or rolling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hepatocyte apoptotic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane raft	ISO Inferred from Sequence Orthology more info
located_in uropod	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: P-selectin glycoprotein ligand 1

Names: selectin P ligand

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.