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ADAM32 ADAM metallopeptidase domain 32 [ Homo sapiens (human) ]

Gene ID: 203102, updated on 3-Apr-2024

Summary

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Official Symbol
ADAM32provided by HGNC
Official Full Name
ADAM metallopeptidase domain 32provided by HGNC
Primary source
HGNC:HGNC:15479
See related
Ensembl:ENSG00000197140 MIM:618602; AllianceGenome:HGNC:15479
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. This gene is predominantly expressed in the testis. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an metalloprotease, disintegrin and epidermal growth factor-like domains. This gene is located in a cluster of other disintegrin and metallopeptidase family genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Expression
Restricted expression toward testis (RPKM 20.2) See more
Orthologs
all
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Genomic context

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See ADAM32 in Genome Data Viewer
Location:
8p11.22
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (39107529..39284917)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (39384664..39562013)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (38965048..39142436)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38853156-38853678 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38853679-38854200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27275 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27277 Neighboring gene TM2 domain containing 2 Neighboring gene Sharpr-MPRA regulatory region 279 Neighboring gene ADAM metallopeptidase domain 9 Neighboring gene small nucleolar RNA, C/D box 38D Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:39038237-39039436 Neighboring gene ribosomal protein L3 pseudogene 10 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:39084432-39085631 Neighboring gene lysine acetyltransferase 2B pseudogene Neighboring gene ADAM metallopeptidase domain 5 (pseudogene)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification and characterization of ADAM32 with testis-predominant gene expression. Choi I, et al. Gene, 2003 Jan 30. PMID 12568724
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. Zhang Z, et al. Protein Sci, 2004 Oct. PMID 15340161, Free PMC Article
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Olsen JV, et al. Cell, 2006 Nov 3. PMID 17081983
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ26299, FLJ29004

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in male gonad development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 32
Names
a disintegrin and metalloprotease domain 32
a disintegrin and metalloproteinase domain 32
metalloproteinase 12-like protein
testicular tissue protein Li 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313994.1 → NP_001300923.1  disintegrin and metalloproteinase domain-containing protein 32 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks multiple alternate exons in the coding region and uses an alternate translation start site, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC105091, AK300148, BC026169, BI559590
    Consensus CDS
    CCDS83286.1
    UniProtKB/TrEMBL
    B4DTC2, E7EPX8
    Related
    ENSP00000405978.2, ENST00000437682.6
    Conserved Domains (5) summary
    cd04269
    Location:194 → 312
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:313 → 376
    Disintegrin; Disintegrin
    pfam01562
    Location:45 → 150
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08516
    Location:380 → 494
    ADAM_CR; ADAM cysteine-rich
    pfam14797
    Location:615 → 687
    SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex

  2. NM_145004.7 → NP_659441.4  disintegrin and metalloproteinase domain-containing protein 32 isoform 1 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC105091, AC105185
    Consensus CDS
    CCDS47846.1
    UniProtKB/Swiss-Prot
    Q8TC27, Q8TC42
    UniProtKB/TrEMBL
    A0A140VJD9
    Related
    ENSP00000369238.4, ENST00000379907.9
    Conserved Domains (5) summary
    pfam00200
    Location:400 → 474
    Disintegrin; Disintegrin
    pfam01421
    Location:187 → 383
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:27 → 144
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08516
    Location:479 → 593
    ADAM_CR; ADAM cysteine-rich
    pfam14797
    Location:714 → 786
    SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    39107529..39284917
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544433.3 → XP_011542735.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X2

    UniProtKB/TrEMBL
    A0A140VJD9
    Conserved Domains (6) summary
    cd04269
    Location:187 → 381
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:400 → 475
    Disintegrin; Disintegrin
    pfam01421
    Location:187 → 383
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:40 → 143
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08516
    Location:479 → 593
    ADAM_CR; ADAM cysteine-rich
    pfam14797
    Location:714 → 773
    SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex

  2. XM_006716298.4 → XP_006716361.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X1

    UniProtKB/TrEMBL
    A0A140VJD9
    Conserved Domains (5) summary
    cd04269
    Location:187 → 381
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:400 → 475
    Disintegrin; Disintegrin
    pfam01421
    Location:187 → 383
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:40 → 143
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08516
    Location:479 → 593
    ADAM_CR; ADAM cysteine-rich

  3. XM_017013184.3 → XP_016868673.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X4

    UniProtKB/TrEMBL
    A0A140VJD9

  4. XM_006716299.3 → XP_006716362.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X7

    UniProtKB/TrEMBL
    E7ER82
    Related
    ENSP00000429422.1, ENST00000519315.5
    Conserved Domains (5) summary
    cd04269
    Location:187 → 305
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:306 → 369
    Disintegrin; Disintegrin
    pfam01562
    Location:40 → 143
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08516
    Location:373 → 487
    ADAM_CR; ADAM cysteine-rich
    pfam14797
    Location:608 → 680
    SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex

  5. XM_011544434.3 → XP_011542736.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X6

    UniProtKB/TrEMBL
    E7ER82
    Conserved Domains (6) summary
    cd04269
    Location:187 → 308
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:327 → 402
    Disintegrin; Disintegrin
    pfam01421
    Location:187 → 310
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:40 → 143
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08516
    Location:406 → 520
    ADAM_CR; ADAM cysteine-rich
    pfam14797
    Location:641 → 713
    SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex

  6. XM_017013183.3 → XP_016868672.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X3

    UniProtKB/TrEMBL
    A0A140VJD9

  7. XM_047421494.1 → XP_047277450.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X9

  8. XM_017013186.3 → XP_016868675.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X8

  9. XM_017013185.3 → XP_016868674.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X5

    UniProtKB/TrEMBL
    A0A140VJD9

  10. XM_017013188.2 → XP_016868677.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X11

  11. XM_017013187.2 → XP_016868676.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X10

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187577.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    13212..190632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328846.1 → XP_054184821.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X2

  2. XM_054328845.1 → XP_054184820.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X1

  3. XM_054328848.1 → XP_054184823.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X4

  4. XM_054328851.1 → XP_054184826.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X7

  5. XM_054328852.1 → XP_054184827.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X12

  6. XM_054328850.1 → XP_054184825.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X6

  7. XM_054328847.1 → XP_054184822.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X3

  8. XM_054328854.1 → XP_054184829.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X9

  9. XM_054328853.1 → XP_054184828.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X8

  10. XM_054328849.1 → XP_054184824.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X5

  11. XM_054328857.1 → XP_054184832.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X11

  12. XM_054328855.1 → XP_054184830.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X10

  13. XM_054328856.1 → XP_054184831.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X13

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    39384664..39562013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360000.1 → XP_054215975.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X2

  2. XM_054359999.1 → XP_054215974.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X1

  3. XM_054360002.1 → XP_054215977.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X4

  4. XM_054360005.1 → XP_054215980.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X7

  5. XM_054360006.1 → XP_054215981.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X14

  6. XM_054360004.1 → XP_054215979.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X6

  7. XM_054360001.1 → XP_054215976.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X3

  8. XM_054360008.1 → XP_054215983.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X9

  9. XM_054360007.1 → XP_054215982.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X8

  10. XM_054360003.1 → XP_054215978.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X5

  11. XM_054360010.1 → XP_054215985.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X11

  12. XM_054360009.1 → XP_054215984.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X10

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TC27.2 GenPept UniProtKB/Swiss-Prot:Q8TC27

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