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TCTE1 t-complex-associated-testis-expressed 1 [ Homo sapiens (human) ]

Gene ID: 202500, updated on 2-Nov-2024

Summary

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Official Symbol
TCTE1provided by HGNC
Official Full Name
t-complex-associated-testis-expressed 1provided by HGNC
Primary source
HGNC:HGNC:11693
See related
Ensembl:ENSG00000146221 MIM:186975; AllianceGenome:HGNC:11693
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRC5; D6S46; FAP155
Summary
Predicted to be involved in flagellated sperm motility. Predicted to be located in sperm flagellum. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis (RPKM 12.5) See more
Orthologs
mouse all
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Genomic context

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See TCTE1 in Genome Data Viewer
Location:
6p21.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (44278734..44297698, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (44112859..44131845, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (44246471..44265435, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44222709-44223424 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:44224854-44225567 Neighboring gene microRNA 4647 Neighboring gene solute carrier family 35 member B2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24635 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24636 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24637 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44232415-44232914 Neighboring gene NFKB inhibitor epsilon Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44243146-44243938 Neighboring gene transmembrane protein 151B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17263 Neighboring gene uncharacterized LOC124901322 Neighboring gene alanyl-tRNA synthetase 2, mitochondrial Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:44280829-44281388 Neighboring gene spermatogenesis associated serine rich 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91950

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Sequence divergence within the sperm-specific polypeptide TCTE1 is correlated with species-specific differences in sperm binding to zona-intact eggs. Juneja R, et al. J Androl, 1998 Mar-Apr. PMID 9570741
  2. Linkage mapping and fluorescence in situ hybridization of TCTE1 on human chromosome 6p: analysis of dinucleotide polymorphisms on native gels. Kwiatkowski TJ Jr, et al. Genomics, 1991 Aug. PMID 1916824
  3. Loss of DRC1 function leads to multiple morphological abnormalities of the sperm flagella and male infertility in human and mouse. Zhang J, et al. Hum Mol Genet, 2021 Oct 13. PMID 34169321, Free PMC Article
  4. A mouse chromosome 17 gene encodes a testes-specific transcript with unusual properties. Sarvetnick N, et al. Immunogenetics, 1989. PMID 2568335
  5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. Hosgood HD 3rd, et al. Occup Environ Med, 2009 Dec. PMID 19773279, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Homology

Clone Names

  • FLJ50041, MGC33600

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
dynein regulatory complex subunit 5
Names
T-complex-associated testis-expressed protein 1
tcte-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182539.4 → NP_872345.2  dynein regulatory complex subunit 5

    See identical proteins and their annotated locations for NP_872345.2

    Status: VALIDATED

    Source sequence(s)
    AA732744, AK301825, AL353588
    Consensus CDS
    CCDS4910.1
    UniProtKB/Swiss-Prot
    B4DX59, Q5JU00, Q8IYS6
    Related
    ENSP00000360560.4, ENST00000371505.5
    Conserved Domains (2) summary
    cd00116
    Location:179 → 489
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:309 → 335
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    44278734..44297698 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418273.1 → XP_047274229.1  dynein regulatory complex subunit 5 isoform X1

    UniProtKB/Swiss-Prot
    B4DX59, Q5JU00, Q8IYS6

  2. XM_005248873.3 → XP_005248930.1  dynein regulatory complex subunit 5 isoform X2

    Conserved Domains (1) summary
    cl39015
    Location:179 → 402
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  3. XM_005248872.2 → XP_005248929.1  dynein regulatory complex subunit 5 isoform X1

    See identical proteins and their annotated locations for XP_005248929.1

    UniProtKB/Swiss-Prot
    B4DX59, Q5JU00, Q8IYS6
    Conserved Domains (2) summary
    cd00116
    Location:179 → 489
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:309 → 335
    LRR_RI; leucine-rich repeat [structural motif]

  4. XM_047418272.1 → XP_047274228.1  dynein regulatory complex subunit 5 isoform X1

    UniProtKB/Swiss-Prot
    B4DX59, Q5JU00, Q8IYS6

  5. XM_011514338.3 → XP_011512640.1  dynein regulatory complex subunit 5 isoform X1

    See identical proteins and their annotated locations for XP_011512640.1

    UniProtKB/Swiss-Prot
    B4DX59, Q5JU00, Q8IYS6
    Conserved Domains (2) summary
    cd00116
    Location:179 → 489
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:309 → 335
    LRR_RI; leucine-rich repeat [structural motif]

  6. XM_006715009.4 → XP_006715072.1  dynein regulatory complex subunit 5 isoform X3

    See identical proteins and their annotated locations for XP_006715072.1

    Conserved Domains (2) summary
    cd00116
    Location:80 → 390
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:210 → 236
    LRR_RI; leucine-rich repeat [structural motif]

  7. XM_005248874.3 → XP_005248931.1  dynein regulatory complex subunit 5 isoform X3

    See identical proteins and their annotated locations for XP_005248931.1

    Conserved Domains (2) summary
    cd00116
    Location:80 → 390
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:210 → 236
    LRR_RI; leucine-rich repeat [structural motif]

  8. XM_011514339.3 → XP_011512641.1  dynein regulatory complex subunit 5 isoform X3

    See identical proteins and their annotated locations for XP_011512641.1

    Conserved Domains (2) summary
    cd00116
    Location:80 → 390
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:210 → 236
    LRR_RI; leucine-rich repeat [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    44112859..44131845 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354439.1 → XP_054210414.1  dynein regulatory complex subunit 5 isoform X2

  2. XM_054354436.1 → XP_054210411.1  dynein regulatory complex subunit 5 isoform X1

  3. XM_054354438.1 → XP_054210413.1  dynein regulatory complex subunit 5 isoform X1

  4. XM_054354437.1 → XP_054210412.1  dynein regulatory complex subunit 5 isoform X1

  5. XM_054354442.1 → XP_054210417.1  dynein regulatory complex subunit 5 isoform X3

  6. XM_054354440.1 → XP_054210415.1  dynein regulatory complex subunit 5 isoform X3

  7. XM_054354441.1 → XP_054210416.1  dynein regulatory complex subunit 5 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5JU00.1 GenPept UniProtKB/Swiss-Prot:Q5JU00

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