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Sat1 spermidine/spermine N1-acetyl transferase 1 [ Mus musculus (house mouse) ]

Gene ID: 20229, updated on 2-Nov-2024

Summary

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Official Symbol
Sat1provided by MGI
Official Full Name
spermidine/spermine N1-acetyl transferase 1provided by MGI
Primary source
MGI:MGI:98233
See related
Ensembl:ENSMUSG00000025283 AllianceGenome:MGI:98233
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sat; SSAT
Summary
Predicted to enable diamine N-acetyltransferase activity; identical protein binding activity; and spermidine binding activity. Acts upstream of or within regulation of cell population proliferation. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human SAT1 (spermidine/spermine N1-acetyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in bladder adult (RPKM 89.1), placenta adult (RPKM 43.0) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Sat1 in Genome Data Viewer
Location:
X F3; X 72.38 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (153996128..153999345, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (155213126..155216449, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 1 Neighboring gene 60S acidic ribosomal protein P0-like Neighboring gene STARR-seq mESC enhancer starr_48134 Neighboring gene ribosomal protein L7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_48136 Neighboring gene acyl-CoA thioesterase 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Enhanced polyamine catabolism disturbs hematopoietic lineage commitment and leads to a myeloproliferative disease in mice overexpressing spermidine/spermine N¹-acetyltransferase. Pirnes-Karhu S, et al. Amino Acids, 2014 Mar. PMID 23836421
  2. Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts. Uimari A, et al. Biochem J, 2009 Jul 29. PMID 19473115, Free PMC Article
  3. The role of spermidine/spermine N1-acetyltransferase in endotoxin-induced acute kidney injury. Zahedi K, et al. Am J Physiol Cell Physiol, 2010 Jul. PMID 20392931, Free PMC Article
  4. Polyamine pathway contributes to the pathogenesis of Parkinson disease. Lewandowski NM, et al. Proc Natl Acad Sci U S A, 2010 Sep 28. PMID 20837543, Free PMC Article
  5. Activated polyamine catabolism depletes acetyl-CoA pools and suppresses prostate tumor growth in TRAMP mice. Kee K, et al. J Biol Chem, 2004 Sep 17. PMID 15252047

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss-of-function variants in SAT1 cause X-linked childhood-onset systemic lupus erythematosus.
    Title: Loss-of-function variants in SAT1 cause X-linked childhood-onset systemic lupus erythematosus.
  2. Activation of SSAT1/ALOX15 Axis Aggravates Cerebral Ischemia/Reperfusion Injury via Triggering Neuronal Ferroptosis.
    Title: Activation of SSAT1/ALOX15 Axis Aggravates Cerebral Ischemia/Reperfusion Injury via Triggering Neuronal Ferroptosis.
  3. Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia.
    Title: Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia.
  4. SAT1 activation plays a key role in cold and beta3-AR agonist-induced beige adipocyte biogenesis and low-grade inflammation.
    Title: Spermidine/spermine N1-acetyltransferase-mediated polyamine catabolism regulates beige adipocyte biogenesis.
  5. the level of SSAT enzyme activity affected osteoblastogenesis and hence influenced bone remodeling and the bone phenotype in mice
    Title: Overexpression of spermidine/spermine N1-acetyltransferase impairs osteoblastogenesis and alters mouse bone phenotype.
  6. Enhanced SSAT expression by proximal tubule epithelial cells leads to tubular damage, and its deficiency reduces the severity of renal I/R injury through reduction of cellular damage and modulation of the innate immune response
    Title: Proximal tubule epithelial cell specific ablation of the spermidine/spermine N1-acetyltransferase gene reduces the severity of renal ischemia/reperfusion injury.
  7. The SSAT overexpression and the concomitantly accelerated polyamine metabolism in hematopoietic cells and bone marrow microenvironment affect lineage commitment and lead to the development of a mouse myeloproliferative disease in SSAT mice.
    Title: Enhanced polyamine catabolism disturbs hematopoietic lineage commitment and leads to a myeloproliferative disease in mice overexpressing spermidine/spermine N¹-acetyltransferase.
  8. the results indicate that transcriptional modulation of the SAT1 gene is not a significant component of the hyperoxaluria observed in these rat models
    Title: Hyperoxaluric rats do not exhibit alterations in renal expression patterns of Slc26a1 (SAT1) mRNA or protein.
  9. study suggests that SSAT overexpression obtained in SSAT mice enhances the anti-inflammatory actions in the acute phase of LPS-induced immune response
    Title: Lipopolysaccharide-induced anti-inflammatory acute phase response is enhanced in spermidine/spermine N1-acetyltransferase (SSAT) overexpressing mice.
  10. Expression of SSAT increases in kidneys subjected to endotoxic acute kidney injury and that increased polyamine back conversion and oxidation contribute to tubular damage in endotoxin-induced AKI.
    Title: The role of spermidine/spermine N1-acetyltransferase in endotoxin-induced acute kidney injury.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables N-acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables diamine N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables diamine N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables diamine N-acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables spermidine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables spermidine binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in polyamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in polyamine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in polyamine catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in polyamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in putrescine catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in spermidine acetylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermidine acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in spermidine acetylation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within spermine catabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
diamine acetyltransferase 1
Names
SSAT-1
polyamine N-acetyltransferase 1
putrescine acetyltransferase
spermidine/spermine N(1)-acetyltransferase 1
NP_001412931.1
NP_033147.1
XP_036017762.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001426002.1 → NP_001412931.1  diamine acetyltransferase 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longer isoform (3).
    Source sequence(s)
    BX119978, BX119986
    UniProtKB/TrEMBL
    A2BES2
    Related
    ENSMUSP00000108170.4, ENSMUST00000112551.4

  2. NM_009121.5 → NP_033147.1  diamine acetyltransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_033147.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BX119978, BX119986
    Consensus CDS
    CCDS30495.1
    UniProtKB/Swiss-Prot
    P48026, Q3U444
    Related
    ENSMUSP00000026318.9, ENSMUST00000026318.15
    Conserved Domains (1) summary
    pfam00583
    Location:48 → 144
    Acetyltransf_1; Acetyltransferase (GNAT) family

RNA

  1. NR_189657.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BX119978, BX119986

  2. NR_189658.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BX119978, BX119986
    Related
    ENSMUST00000152463.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    153996128..153999345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161869.1 → XP_036017762.1  diamine acetyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    Q3V2Q2
    Related
    ENSMUST00000150046.2
    Conserved Domains (1) summary
    pfam00583
    Location:4 → 69
    Acetyltransf_1; Acetyltransferase (GNAT) family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48026.1 GenPept UniProtKB/Swiss-Prot:P48026

Gene LinkOut

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