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Rras related RAS viral (r-ras) oncogene [ Mus musculus (house mouse) ]

Gene ID: 20130, updated on 2-Nov-2024

Summary

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Official Symbol
Rrasprovided by MGI
Official Full Name
related RAS viral (r-ras) oncogeneprovided by MGI
Primary source
MGI:MGI:98179
See related
Ensembl:ENSMUSG00000038387 AllianceGenome:MGI:98179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rras1
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Acts upstream of or within negative regulation of Schwann cell migration. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human RRAS (RAS related). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 109.9), bladder adult (RPKM 109.8) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Rras in Genome Data Viewer
Location:
7 B3; 7 29.08 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44665686..44671070)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45017942..45021646)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene interferon regulatory factor 3 Neighboring gene SR-related CTD-associated factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E130 Neighboring gene microRNA 7054 Neighboring gene STARR-positive B cell enhancer ABC_E871 Neighboring gene proline rich 12 Neighboring gene STARR-positive B cell enhancer ABC_E6541 Neighboring gene STARR-positive B cell enhancer ABC_E2235 Neighboring gene proline-rich Gla (G-carboxyglutamic acid) polypeptide 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52317657-52317840

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Akt3 activation by R-Ras in an endothelial cell enforces quiescence and barrier stability of neighboring endothelial cells via Jagged1. Herrera JL, et al. Cell Rep, 2024 Mar 26. PMID 38402584, Free PMC Article
  2. Proteomics Analysis of R-Ras Deficiency in Oxygen Induced Retinopathy. Vähätupa M, et al. Int J Mol Sci, 2023 Apr 26. PMID 37175621, Free PMC Article
  3. R-Ras is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesis. Komatsu M, et al. Nat Med, 2005 Dec. PMID 16286923
  4. Palmitoylation regulates vesicular trafficking of R-Ras to membrane ruffles and effects on ruffling and cell spreading. Wurtzel JG, et al. Small GTPases, 2012 Jul-Sep. PMID 22751447, Free PMC Article
  5. R-Ras Deficiency in Pericytes Causes Frequent Microphthalmia and Perturbs Retinal Vascular Development. Herrera JL, et al. J Vasc Res, 2021. PMID 33873190, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Proteomics Analysis of R-Ras Deficiency in Oxygen Induced Retinopathy.
    Title: Proteomics Analysis of R-Ras Deficiency in Oxygen Induced Retinopathy.
  2. R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types of the Central Nervous System.
    Title: R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types of the Central Nervous System.
  3. R-Ras Deficiency in Pericytes Causes Frequent Microphthalmia and Perturbs Retinal Vascular Development.
    Title: R-Ras Deficiency in Pericytes Causes Frequent Microphthalmia and Perturbs Retinal Vascular Development.
  4. Flightless anchors IQGAP1 and R-ras to mediate cell extension formation and matrix remodeling.
    Title: Flightless anchors IQGAP1 and R-ras to mediate cell extension formation and matrix remodeling.
  5. Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease.
    Title: Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease.
  6. although R-Ras does not influence the skin wound healing itself, the blood vessels lacking R-Ras are leaky and thus could facilitate the access of blood-derived proteins to the wound
    Title: R-Ras regulates vascular permeability, but not overall healing in skin wounds.
  7. FliI is required for the interaction of Rasgap(120) with G3BP1 to regulate R-ras activity and growth of cell extensions.
    Title: The leucine-rich region of Flightless I interacts with R-ras to regulate cell extension formation.
  8. Taken together, despite having reduced number of conventional DC's in the R-Ras KO mice and low expression of CD80 on DC's, the R-Ras KO mice are capable of mounting papain-induced IgE responses comparable to that of the WT mice.
    Title: R-Ras deficiency does not affect papain-induced IgE production in mice.
  9. R-Ras is pro-tumourigenic in the mouse DMBA/TPA tumour model and important for the inflammatory response to DMBA/TPA treatment.
    Title: Resistance of R-Ras knockout mice to skin tumour induction.
  10. the data provide evidence for a role of R-Ras in the mediation of chemokine receptor-mediated signaling in migrating T cells in the high endothelial venules.
    Title: R-Ras Regulates Murine T Cell Migration and Intercellular Adhesion Molecule-1 Binding.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC129444, MGC129445

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables GDP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of Schwann cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in face morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in face morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in leukocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in leukocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of Schwann cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of endothelial cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vasculogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of vasculogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras-related protein R-Ras
Names
Harvey rat sarcoma oncogene, subgroup R
p23
NP_001347061.1
NP_001347062.1
NP_033127.1
XP_036008706.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360132.2 → NP_001347061.1  ras-related protein R-Ras isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC126256
    Conserved Domains (1) summary
    cl21455
    Location:2 → 141
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001360133.2 → NP_001347062.1  ras-related protein R-Ras isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC126256
    Conserved Domains (1) summary
    cl21455
    Location:1 → 99
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_009101.4 → NP_033127.1  ras-related protein R-Ras isoform 1

    See identical proteins and their annotated locations for NP_033127.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC126256
    Consensus CDS
    CCDS21226.1
    UniProtKB/Swiss-Prot
    P10833
    UniProtKB/TrEMBL
    Q3U1N3
    Related
    ENSMUSP00000042150.8, ENSMUST00000044111.10
    Conserved Domains (1) summary
    cd04145
    Location:28 → 191
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44665686..44671070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152813.1 → XP_036008706.1  ras-related protein R-Ras isoform X1

    UniProtKB/Swiss-Prot
    P10833
    UniProtKB/TrEMBL
    Q3U1N3
    Conserved Domains (1) summary
    cd04145
    Location:28 → 191
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10833.1 GenPept UniProtKB/Swiss-Prot:P10833

Gene LinkOut

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