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ARHGAP27 Rho GTPase activating protein 27 [ Homo sapiens (human) ]

Gene ID: 201176, updated on 7-Apr-2024

Summary

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Official Symbol
ARHGAP27provided by HGNC
Official Full Name
Rho GTPase activating protein 27provided by HGNC
Primary source
HGNC:HGNC:31813
See related
Ensembl:ENSG00000159314 MIM:610591; AllianceGenome:HGNC:31813
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP905; SH3D20; SH3P20; CAMGAP1
Summary
This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may pay a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013]
Expression
Ubiquitous expression in esophagus (RPKM 12.5), spleen (RPKM 12.5) and 23 other tissues See more
Orthologs
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Genomic context

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See ARHGAP27 in Genome Data Viewer
Location:
17q21.31
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (45393908..45432870, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (46247641..46286582, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43471274..43510236, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 443 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:43414932-43415093 Neighboring gene OCT4 hESC enhancer GRCh37_chr17:43427135-43427636 Neighboring gene uncharacterized LOC105371796 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:43448585-43449784 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43450691-43451263 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43451264-43451835 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:43453675-43454480 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43462245-43463212 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43471827-43472486 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:43473118-43473275 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43488992-43489492 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43501082-43501588 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43501589-43502093 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43502838-43503408 Neighboring gene uncharacterized LOC124904016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43507020-43507520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43507521-43508021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43513205-43513858 Neighboring gene pleckstrin homology and RUN domain containing M1 Neighboring gene uncharacterized LOC124904113 Neighboring gene microRNA 4315-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification and characterization of ARHGAP27 gene in silico. Katoh Y, et al. Int J Mol Med, 2004 Nov. PMID 15492870
  2. Identification and characterization of a novel Rho GTPase activating protein implicated in receptor-mediated endocytosis. Sakakibara T, et al. FEBS Lett, 2004 May 21. PMID 15147912
  3. Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships. Peck J, et al. FEBS Lett, 2002 Sep 25. PMID 12297274
  4. Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. Edwards TL, et al. Ann Hum Genet, 2010 Mar. PMID 20070850, Free PMC Article
  5. Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants. Wistow G, et al. Mol Vis, 2002 Jun 15. PMID 12107413

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ35572, FLJ43547, FLJ76025, MGC78393, MGC120624

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTPase activator activity TAS
Traceable Author Statement
more info
  
enables SH3 domain binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in positive regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in receptor-mediated endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 27
Names
CIN85-associated multi-domain-containing Rho GTPase-activating protein 1
SH3 domain containing 20
SH3 domain-containing protein 20
rho-type GTPase-activating protein 27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282290.2 → NP_001269219.1  rho GTPase-activating protein 27 isoform d

    See identical proteins and their annotated locations for NP_001269219.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).
    Source sequence(s)
    AC003070, AC091132
    Consensus CDS
    CCDS74082.1
    UniProtKB/Swiss-Prot
    A4FU35, A8K3N5, C9JTF3, Q494U0, Q6NWZ8, Q6ZUM4, Q8WY58
    UniProtKB/TrEMBL
    A0A0G2JNY3
    Related
    ENSP00000509127.1, ENST00000685559.1
    Conserved Domains (6) summary
    smart00456
    Location:417 → 443
    WW; Domain with 2 conserved Trp (W) residues
    cd12069
    Location:10 → 66
    SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
    cd04403
    Location:695 → 881
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:499 → 613
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:499 → 611
    PH; PH domain
    pfam00397
    Location:247 → 278
    WW; WW domain

  2. NM_001385384.1 → NP_001372313.1  rho GTPase-activating protein 27 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC003070, AC091132
    Consensus CDS
    CCDS92343.1
    UniProtKB/TrEMBL
    A0A0G2JRG8, E9PIR1
    Related
    ENST00000531735.5
    Conserved Domains (5) summary
    cd12069
    Location:10 → 66
    SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
    COG5104
    Location:239 → 376
    PRP40; Splicing factor [RNA processing and modification]
    cd04403
    Location:673 → 859
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:477 → 591
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:247 → 278
    WW; WW domain

  3. NM_001385385.1 → NP_001372314.1  rho GTPase-activating protein 27 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC003070
    Consensus CDS
    CCDS92341.1
    UniProtKB/TrEMBL
    A0A8I5KVA8
    Related
    ENSP00000508575.1, ENST00000691061.1
    Conserved Domains (4) summary
    COG5104
    Location:39 → 176
    PRP40; Splicing factor [RNA processing and modification]
    cd04403
    Location:495 → 681
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:299 → 413
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:47 → 78
    WW; WW domain

  4. NM_001385386.1 → NP_001372315.1  rho GTPase-activating protein 27 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC003070
    Conserved Domains (4) summary
    COG5104
    Location:39 → 176
    PRP40; Splicing factor [RNA processing and modification]
    cd04403
    Location:478 → 664
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:277 → 391
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:47 → 78
    WW; WW domain

  5. NM_001385387.1 → NP_001372316.1  rho GTPase-activating protein 27 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC003070
    Consensus CDS
    CCDS92340.1
    UniProtKB/TrEMBL
    E9PNT2
    Related
    ENSP00000432762.1, ENST00000532038.5
    Conserved Domains (4) summary
    COG5104
    Location:39 → 176
    PRP40; Splicing factor [RNA processing and modification]
    cd04403
    Location:473 → 659
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:277 → 391
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:47 → 78
    WW; WW domain

  6. NM_001385388.1 → NP_001372317.1  rho GTPase-activating protein 27 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC003070
    Conserved Domains (4) summary
    COG5104
    Location:39 → 176
    PRP40; Splicing factor [RNA processing and modification]
    cd13233
    Location:277 → 391
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:47 → 78
    WW; WW domain
    cl02570
    Location:473 → 633
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  7. NM_001385389.1 → NP_001372318.1  rho GTPase-activating protein 27 isoform j

    Status: VALIDATED

    Source sequence(s)
    AC003070
    Conserved Domains (4) summary
    COG5104
    Location:39 → 176
    PRP40; Splicing factor [RNA processing and modification]
    cd13233
    Location:299 → 413
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:47 → 78
    WW; WW domain
    cl02570
    Location:495 → 595
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  8. NM_001385390.1 → NP_001372319.1  rho GTPase-activating protein 27 isoform k

    Status: VALIDATED

    Source sequence(s)
    AC003070
    Consensus CDS
    CCDS92342.1
    UniProtKB/TrEMBL
    E9PNX6
    Related
    ENSP00000437100.2, ENST00000528677.2
    Conserved Domains (4) summary
    PRK08691
    Location:24 → 228
    PRK08691; DNA polymerase III subunits gamma and tau; Validated
    cd04403
    Location:438 → 624
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:242 → 356
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:47 → 78
    WW; WW domain

  9. NM_001385391.1 → NP_001372320.1  rho GTPase-activating protein 27 isoform l

    Status: VALIDATED

    Source sequence(s)
    AC003070
    Conserved Domains (4) summary
    PRK10263
    Location:13 → 245
    PRK10263; DNA translocase FtsK; Provisional
    cd04403
    Location:416 → 602
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:220 → 334
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:47 → 78
    WW; WW domain

  10. NM_001385392.1 → NP_001372321.1  rho GTPase-activating protein 27 isoform m

    Status: VALIDATED

    Source sequence(s)
    AC003070
    Conserved Domains (4) summary
    PRK10263
    Location:13 → 245
    PRK10263; DNA translocase FtsK; Provisional
    cd13233
    Location:220 → 334
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:47 → 78
    WW; WW domain
    cl02570
    Location:416 → 576
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  11. NM_001385393.1 → NP_001372322.1  rho GTPase-activating protein 27 isoform n

    Status: VALIDATED

    Source sequence(s)
    AC003070, AC091132
    UniProtKB/TrEMBL
    A0A0C4DGE6
    Conserved Domains (4) summary
    cd00201
    Location:52 → 82
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:359 → 545
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:158 → 272
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:74 → 101
    WW; WW domain

  12. NM_001385394.1 → NP_001372323.1  rho GTPase-activating protein 27 isoform o

    Status: VALIDATED

    Source sequence(s)
    AC003070, AC091132
    UniProtKB/TrEMBL
    A0A0C4DGE6
    Related
    ENST00000703660.1
    Conserved Domains (4) summary
    cd00201
    Location:52 → 82
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:332 → 518
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:136 → 250
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:74 → 101
    WW; WW domain

  13. NM_001385395.1 → NP_001372324.1  rho GTPase-activating protein 27 isoform p

    Status: VALIDATED

    Source sequence(s)
    AC003070, AC091132
    UniProtKB/TrEMBL
    A0A0C4DGE6
    Conserved Domains (4) summary
    cd00201
    Location:52 → 82
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd13233
    Location:158 → 272
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:74 → 101
    WW; WW domain
    cl02570
    Location:354 → 454
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  14. NM_001385396.1 → NP_001372325.1  rho GTPase-activating protein 27 isoform q

    Status: VALIDATED

    Source sequence(s)
    AC003070, AC091132
    UniProtKB/TrEMBL
    A0A0C4DGE6
    Conserved Domains (4) summary
    cd00201
    Location:52 → 82
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:328 → 485
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:136 → 250
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:74 → 101
    WW; WW domain

  15. NM_001385397.1 → NP_001372326.1  rho GTPase-activating protein 27 isoform r

    Status: VALIDATED

    Source sequence(s)
    AC003070, AC091132
    UniProtKB/TrEMBL
    A0A0C4DGE6
    Conserved Domains (3) summary
    smart00456
    Location:12 → 38
    WW; Domain with 2 conserved Trp (W) residues
    cd04403
    Location:290 → 476
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:94 → 208
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

  16. NM_001385398.1 → NP_001372327.1  rho GTPase-activating protein 27 isoform s

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19), as well as variant 20, encodes isoform s.
    Source sequence(s)
    AC003070, AC091132
    UniProtKB/TrEMBL
    A0A0C4DGE6
    Conserved Domains (3) summary
    smart00456
    Location:12 → 38
    WW; Domain with 2 conserved Trp (W) residues
    cd04403
    Location:268 → 454
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:72 → 186
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

  17. NM_001385399.1 → NP_001372328.1  rho GTPase-activating protein 27 isoform s

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20), as well as variant 19, encodes isoform s.
    Source sequence(s)
    AC003070
    UniProtKB/TrEMBL
    A0A0C4DGE6
    Conserved Domains (3) summary
    smart00456
    Location:12 → 38
    WW; Domain with 2 conserved Trp (W) residues
    cd04403
    Location:268 → 454
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:72 → 186
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

  18. NM_174919.4 → NP_777579.2  rho GTPase-activating protein 27 isoform c

    See identical proteins and their annotated locations for NP_777579.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) is a short variant at the 5' end of a much longer ARHGAP27 gene, and differs in the UTRs and CDS compared to variant 4. The encoded isoform (c) is shorter than isoform d.
    Source sequence(s)
    AC091132
    Consensus CDS
    CCDS32670.1
    UniProtKB/TrEMBL
    A0A0G2JP16
    Related
    ENSP00000290470.3, ENST00000290470.3
    Conserved Domains (1) summary
    cd12069
    Location:10 → 66
    SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27

  19. NM_199282.3 → NP_954976.1  rho GTPase-activating protein 27 isoform a

    See identical proteins and their annotated locations for NP_954976.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is a short variant at the 3' end of a longer ARHGAP27 gene and differs in the 5' UTR and CDS compared to variant 4. The encoded isoform (a) is shorter than isoform d.
    Source sequence(s)
    AK125535, BC029634, BC101391, BX386761, CD675139
    Consensus CDS
    CCDS11498.1
    UniProtKB/TrEMBL
    A0A0C4DGE6
    Related
    ENSP00000366121.2, ENST00000376922.6
    Conserved Domains (5) summary
    smart00456
    Location:76 → 102
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:52 → 82
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:354 → 540
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:158 → 272
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:158 → 270
    PH; PH domain

RNA

  1. NR_169600.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC003070, AC091132

  2. NR_169601.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC003070, AC091132

  3. NR_169602.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC003070, AC091132

  4. NR_169603.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC003070, AC091132

  5. NR_169604.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC003070, AC091132

  6. NR_169605.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC003070, AC091132

  7. NR_169606.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC003070, AC091132

  8. NR_169607.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC003070, AC091132

  9. NR_169608.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC003070, AC091132

  10. NR_169609.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC003070, AC091132

  11. NR_169610.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC003070

  12. NR_169611.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC003070

  13. NR_169612.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC003070

  14. NR_169613.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC003070

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    45393908..45432870 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435547.1 → XP_047291503.1  rho GTPase-activating protein 27 isoform X4

  2. XM_047435546.1 → XP_047291502.1  rho GTPase-activating protein 27 isoform X3

  3. XM_011524468.2 → XP_011522770.1  rho GTPase-activating protein 27 isoform X1

    See identical proteins and their annotated locations for XP_011522770.1

    UniProtKB/TrEMBL
    A0A0G2JNY3
    Conserved Domains (6) summary
    smart00456
    Location:417 → 443
    WW; Domain with 2 conserved Trp (W) residues
    cd12069
    Location:10 → 66
    SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
    cd04403
    Location:728 → 914
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:499 → 613
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:499 → 611
    PH; PH domain
    pfam00397
    Location:247 → 278
    WW; WW domain

  4. XM_047435544.1 → XP_047291500.1  rho GTPase-activating protein 27 isoform X2

    UniProtKB/TrEMBL
    E9PIR1

  5. XM_047435543.1 → XP_047291499.1  rho GTPase-activating protein 27 isoform X10

    UniProtKB/Swiss-Prot
    A4FU35, A8K3N5, C9JTF3, Q494U0, Q6NWZ8, Q6ZUM4, Q8WY58

  6. XM_047435545.1 → XP_047291501.1  rho GTPase-activating protein 27 isoform X2

    UniProtKB/TrEMBL
    E9PIR1
    Related
    ENSP00000433942.1, ENST00000532891.6

  7. XM_011524474.2 → XP_011522776.1  rho GTPase-activating protein 27 isoform X8

    See identical proteins and their annotated locations for XP_011522776.1

    UniProtKB/TrEMBL
    A0A0C4DGE6
    Conserved Domains (5) summary
    smart00456
    Location:76 → 102
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:52 → 82
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:387 → 573
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:158 → 272
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:158 → 270
    PH; PH domain

  8. XM_047435550.1 → XP_047291506.1  rho GTPase-activating protein 27 isoform X7

  9. XM_047435548.1 → XP_047291504.1  rho GTPase-activating protein 27 isoform X6

  10. XM_011524472.3 → XP_011522774.1  rho GTPase-activating protein 27 isoform X5

    See identical proteins and their annotated locations for XP_011522774.1

    Conserved Domains (5) summary
    smart00456
    Location:217 → 243
    WW; Domain with 2 conserved Trp (W) residues
    cd04403
    Location:528 → 714
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:299 → 413
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:299 → 411
    PH; PH domain
    pfam00397
    Location:47 → 78
    WW; WW domain

  11. XM_047435551.1 → XP_047291507.1  rho GTPase-activating protein 27 isoform X9

  12. XM_047435549.1 → XP_047291505.1  rho GTPase-activating protein 27 isoform X11

  13. XM_006721750.5 → XP_006721813.1  rho GTPase-activating protein 27 isoform X12

    See identical proteins and their annotated locations for XP_006721813.1

    Conserved Domains (4) summary
    cd12069
    Location:10 → 66
    SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
    cd13233
    Location:499 → 613
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:499 → 611
    PH; PH domain
    pfam00397
    Location:247 → 278
    WW; WW domain

  14. XM_011524473.3 → XP_011522775.1  rho GTPase-activating protein 27 isoform X13

    See identical proteins and their annotated locations for XP_011522775.1

    Conserved Domains (3) summary
    cd12069
    Location:10 → 66
    SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
    pfam00397
    Location:247 → 278
    WW; WW domain
    cl17171
    Location:499 → 582
    PH-like; Pleckstrin homology-like domain

RNA

  1. XR_934416.3 RNA Sequence

  2. XR_001752447.2 RNA Sequence

  3. XR_007065283.1 RNA Sequence

  4. XR_001752448.2 RNA Sequence

  5. XR_007065286.1 RNA Sequence

  6. XR_007065284.1 RNA Sequence

  7. XR_007065285.1 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_167251.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    84429..123368 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328551.1 → XP_054184526.1  rho GTPase-activating protein 27 isoform X14

  2. XM_054328553.1 → XP_054184528.1  rho GTPase-activating protein 27 isoform X3

  3. XM_054328549.1 → XP_054184524.1  rho GTPase-activating protein 27 isoform X1

  4. XM_054328552.1 → XP_054184527.1  rho GTPase-activating protein 27 isoform X15

  5. XM_054328550.1 → XP_054184525.1  rho GTPase-activating protein 27 isoform X1

  6. XM_054328559.1 → XP_054184534.1  rho GTPase-activating protein 27 isoform X8

  7. XM_054328557.1 → XP_054184532.1  rho GTPase-activating protein 27 isoform X7

  8. XM_054328555.1 → XP_054184530.1  rho GTPase-activating protein 27 isoform X6

  9. XM_054328554.1 → XP_054184529.1  rho GTPase-activating protein 27 isoform X5

  10. XM_054328556.1 → XP_054184531.1  rho GTPase-activating protein 27 isoform X11

  11. XM_054328558.1 → XP_054184533.1  rho GTPase-activating protein 27 isoform X12

RNA

  1. XR_008485590.1 RNA Sequence

  2. XR_008485593.1 RNA Sequence

  3. XR_008485592.1 RNA Sequence

  4. XR_008485591.1 RNA Sequence

  5. XR_008485595.1 RNA Sequence

  6. XR_008485597.1 RNA Sequence

  7. XR_008485594.1 RNA Sequence

  8. XR_008485596.1 RNA Sequence

  9. XR_008485598.1 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187663.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    84411..123375 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330093.1 → XP_054186068.1  rho GTPase-activating protein 27 isoform X4

  2. XM_054330092.1 → XP_054186067.1  rho GTPase-activating protein 27 isoform X3

  3. XM_054330088.1 → XP_054186063.1  rho GTPase-activating protein 27 isoform X1

  4. XM_054330089.1 → XP_054186064.1  rho GTPase-activating protein 27 isoform X10

    UniProtKB/Swiss-Prot
    A4FU35, A8K3N5, C9JTF3, Q494U0, Q6NWZ8, Q6ZUM4, Q8WY58

  5. XM_054330090.1 → XP_054186065.1  rho GTPase-activating protein 27 isoform X2

    UniProtKB/TrEMBL
    E9PIR1

  6. XM_054330091.1 → XP_054186066.1  rho GTPase-activating protein 27 isoform X2

    UniProtKB/TrEMBL
    E9PIR1

  7. XM_054330099.1 → XP_054186074.1  rho GTPase-activating protein 27 isoform X8

  8. XM_054330097.1 → XP_054186072.1  rho GTPase-activating protein 27 isoform X7

  9. XM_054330095.1 → XP_054186070.1  rho GTPase-activating protein 27 isoform X6

  10. XM_054330094.1 → XP_054186069.1  rho GTPase-activating protein 27 isoform X5

  11. XM_054330100.1 → XP_054186075.1  rho GTPase-activating protein 27 isoform X9

  12. XM_054330096.1 → XP_054186071.1  rho GTPase-activating protein 27 isoform X11

  13. XM_054330098.1 → XP_054186073.1  rho GTPase-activating protein 27 isoform X12

RNA

  1. XR_008485674.1 RNA Sequence

  2. XR_008485676.1 RNA Sequence

  3. XR_008485675.1 RNA Sequence

  4. XR_008485678.1 RNA Sequence

  5. XR_008485680.1 RNA Sequence

  6. XR_008485677.1 RNA Sequence

  7. XR_008485679.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    46247641..46286582 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315355.1 → XP_054171330.1  rho GTPase-activating protein 27 isoform X4

  2. XM_054315354.1 → XP_054171329.1  rho GTPase-activating protein 27 isoform X3

  3. XM_054315352.1 → XP_054171327.1  rho GTPase-activating protein 27 isoform X1

  4. XM_054315353.1 → XP_054171328.1  rho GTPase-activating protein 27 isoform X2

  5. XM_054315359.1 → XP_054171334.1  rho GTPase-activating protein 27 isoform X8

  6. XM_054315358.1 → XP_054171333.1  rho GTPase-activating protein 27 isoform X7

  7. XM_054315357.1 → XP_054171332.1  rho GTPase-activating protein 27 isoform X6

  8. XM_054315356.1 → XP_054171331.1  rho GTPase-activating protein 27 isoform X5

  9. XM_054315360.1 → XP_054171335.1  rho GTPase-activating protein 27 isoform X9

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001159330.1: Suppressed sequence

    Description
    NM_001159330.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZUM4.3 GenPept UniProtKB/Swiss-Prot:Q6ZUM4

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