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NBPF11 NBPF member 11 [ Homo sapiens (human) ]

Gene ID: 200030, updated on 5-Mar-2024

Summary

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Official Symbol
NBPF11provided by HGNC
Official Full Name
NBPF member 11provided by HGNC
Primary source
HGNC:HGNC:31993
See related
Ensembl:ENSG00000263956 MIM:614001; AllianceGenome:HGNC:31993
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NBPF24
Summary
Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in skin (RPKM 15.7), ovary (RPKM 14.5) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
1q21.2
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (148102151..148152281, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (146655132..146705256)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (147574428..147624560, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene OCT4 hESC enhancer GRCh37_chr1:147520877-147521378 Neighboring gene tRNA-Asn (anticodon GTT) 9-2 Neighboring gene PDE4DIP pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:147532116-147532616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:147532617-147533117 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:146009957-146010457 Neighboring gene profilin 1 pseudogene 4 Neighboring gene ABHD17A pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1638 Neighboring gene uncharacterized LOC105371227 Neighboring gene long intergenic non-protein coding RNA 2805

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Constitutional translocation t(1;17)(p36.31-p36.13;q11.2-q12.1) in a neuroblastoma patient. Establishment of somatic cell hybrids and identification of PND/A12M2 on chromosome 1 and NF1/SCYA7 on chromosome 17 as breakpoint flanking single copy markers. Laureys G, et al. Oncogene, 1995 Mar 16. PMID 7700633
  2. Chibby interacts with NBPF1 and clusterin, two candidate tumor suppressors linked to neuroblastoma. Vandepoele K, et al. Exp Cell Res, 2010 Apr 15. PMID 20096688
  3. A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution. Vandepoele K, et al. Mol Biol Evol, 2005 Nov. PMID 16079250
  4. Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes. Tsuritani K, et al. Genome Res, 2007 Jul. PMID 17567985, Free PMC Article
  5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? Nathan JA, et al. EMBO J, 2013 Feb 20. PMID 23314748, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ61663, DKFZp451B1418

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neuroblastoma breakpoint family member 11
Names
neuroblastoma breakpoint family, member 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101663.5 → NP_001095133.3  neuroblastoma breakpoint family member 11 isoform b

    See identical proteins and their annotated locations for NP_001095133.3

    Status: VALIDATED

    Source sequence(s)
    AC239803
    Consensus CDS
    CCDS41381.2
    UniProtKB/Swiss-Prot
    B1AKG1, B7Z7R4, Q5RGN0, Q86T75
    UniProtKB/TrEMBL
    Q3BBV4
    Related
    ENSP00000484213.1, ENST00000614015.4
    Conserved Domains (2) summary
    COG0419
    Location:11 → 401
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam06758
    Location:682 → 747
    DUF1220; Repeat of unknown function (DUF1220)

  2. NM_001385468.3 → NP_001372397.2  neuroblastoma breakpoint family member 11 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC239803
    Consensus CDS
    CCDS41381.2
    UniProtKB/Swiss-Prot
    B1AKG1, B7Z7R4, Q5RGN0, Q86T75
    UniProtKB/TrEMBL
    Q3BBV4
    Conserved Domains (2) summary
    COG0419
    Location:11 → 401
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam06758
    Location:682 → 747
    DUF1220; Repeat of unknown function (DUF1220)

  3. NM_001385469.3 → NP_001372398.2  neuroblastoma breakpoint family member 11 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC239803
    Consensus CDS
    CCDS41381.2
    UniProtKB/Swiss-Prot
    B1AKG1, B7Z7R4, Q5RGN0, Q86T75
    UniProtKB/TrEMBL
    Q3BBV4
    Related
    ENSP00000507808.1, ENST00000682118.1
    Conserved Domains (2) summary
    COG0419
    Location:11 → 401
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam06758
    Location:682 → 747
    DUF1220; Repeat of unknown function (DUF1220)

  4. NM_001385470.3 → NP_001372399.2  neuroblastoma breakpoint family member 11 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC239803
    Consensus CDS
    CCDS41381.2
    UniProtKB/Swiss-Prot
    B1AKG1, B7Z7R4, Q5RGN0, Q86T75
    UniProtKB/TrEMBL
    Q3BBV4
    Conserved Domains (2) summary
    COG0419
    Location:11 → 401
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam06758
    Location:682 → 747
    DUF1220; Repeat of unknown function (DUF1220)

  5. NM_001385471.1 → NP_001372400.1  neuroblastoma breakpoint family member 11 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC239803
    Consensus CDS
    CCDS41381.2
    UniProtKB/Swiss-Prot
    B1AKG1, B7Z7R4, Q5RGN0, Q86T75
    UniProtKB/TrEMBL
    Q3BBV4
    Conserved Domains (2) summary
    COG0419
    Location:11 → 401
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam06758
    Location:682 → 747
    DUF1220; Repeat of unknown function (DUF1220)

  6. NM_001385472.1 → NP_001372401.1  neuroblastoma breakpoint family member 11 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC239803
    Consensus CDS
    CCDS41381.2
    UniProtKB/Swiss-Prot
    B1AKG1, B7Z7R4, Q5RGN0, Q86T75
    UniProtKB/TrEMBL
    Q3BBV4
    Conserved Domains (2) summary
    COG0419
    Location:11 → 401
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam06758
    Location:682 → 747
    DUF1220; Repeat of unknown function (DUF1220)

  7. NM_001385473.1 → NP_001372402.1  neuroblastoma breakpoint family member 11 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC239803
    Consensus CDS
    CCDS41381.2
    UniProtKB/Swiss-Prot
    B1AKG1, B7Z7R4, Q5RGN0, Q86T75
    UniProtKB/TrEMBL
    Q3BBV4
    Conserved Domains (2) summary
    COG0419
    Location:11 → 401
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam06758
    Location:682 → 747
    DUF1220; Repeat of unknown function (DUF1220)

  8. NM_001385474.1 → NP_001372403.1  neuroblastoma breakpoint family member 11 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC239803
    Consensus CDS
    CCDS41381.2
    UniProtKB/Swiss-Prot
    B1AKG1, B7Z7R4, Q5RGN0, Q86T75
    UniProtKB/TrEMBL
    Q3BBV4
    Conserved Domains (2) summary
    COG0419
    Location:11 → 401
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam06758
    Location:682 → 747
    DUF1220; Repeat of unknown function (DUF1220)

  9. NM_001385475.1 → NP_001372404.1  neuroblastoma breakpoint family member 11 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC239803
    Consensus CDS
    CCDS41381.2
    UniProtKB/Swiss-Prot
    B1AKG1, B7Z7R4, Q5RGN0, Q86T75
    UniProtKB/TrEMBL
    Q3BBV4
    Conserved Domains (2) summary
    COG0419
    Location:11 → 401
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam06758
    Location:682 → 747
    DUF1220; Repeat of unknown function (DUF1220)

  10. NM_001385476.1 → NP_001372405.1  neuroblastoma breakpoint family member 11 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC239803
    Consensus CDS
    CCDS41381.2
    UniProtKB/Swiss-Prot
    B1AKG1, B7Z7R4, Q5RGN0, Q86T75
    UniProtKB/TrEMBL
    Q3BBV4
    Conserved Domains (2) summary
    COG0419
    Location:11 → 401
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam06758
    Location:682 → 747
    DUF1220; Repeat of unknown function (DUF1220)

  11. NM_001385477.1 → NP_001372406.1  neuroblastoma breakpoint family member 11 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC239803
    UniProtKB/TrEMBL
    A0A087WTH4
    Conserved Domains (1) summary
    pfam06758
    Location:607 → 672
    DUF1220; Repeat of unknown function (DUF1220)

  12. NM_001385478.1 → NP_001372407.1  neuroblastoma breakpoint family member 11 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC239803
    UniProtKB/TrEMBL
    A0A087WTH4
    Conserved Domains (1) summary
    pfam06758
    Location:607 → 672
    DUF1220; Repeat of unknown function (DUF1220)

  13. NM_001385479.1 → NP_001372408.1  neuroblastoma breakpoint family member 11 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC239803
    UniProtKB/TrEMBL
    A0A087WTH4
    Conserved Domains (1) summary
    pfam06758
    Location:607 → 672
    DUF1220; Repeat of unknown function (DUF1220)

  14. NM_001385480.1 → NP_001372409.1  neuroblastoma breakpoint family member 11 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC239803
    UniProtKB/TrEMBL
    A0A087WTH4
    Related
    ENSP00000477874.1, ENST00000613531.1
    Conserved Domains (1) summary
    pfam06758
    Location:607 → 672
    DUF1220; Repeat of unknown function (DUF1220)

  15. NM_183372.9 → NP_899228.5  neuroblastoma breakpoint family member 11 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC239803
    Consensus CDS
    CCDS41381.2
    UniProtKB/Swiss-Prot
    B1AKG1, B7Z7R4, Q5RGN0, Q86T75
    UniProtKB/TrEMBL
    Q3BBV4
    Related
    ENSP00000477509.1, ENST00000615281.4
    Conserved Domains (2) summary
    COG0419
    Location:11 → 401
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam06758
    Location:682 → 747
    DUF1220; Repeat of unknown function (DUF1220)

RNA

  1. NR_046188.5 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC239803

  2. NR_110864.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC239803
    Related
    ENST00000614506.4

  3. NR_169628.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC239803

  4. NR_169629.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC239803

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    148102151..148152281 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    146655132..146705256
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86T75.3 GenPept UniProtKB/Swiss-Prot:Q86T75

Gene LinkOut

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Chemical Information
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