U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF627 zinc finger protein 627 [ Homo sapiens (human) ]

Gene ID: 199692, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
ZNF627provided by HGNC
Official Full Name
zinc finger protein 627provided by HGNC
Primary source
HGNC:HGNC:30570
See related
Ensembl:ENSG00000198551 MIM:612248; AllianceGenome:HGNC:30570
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 7.4), endometrium (RPKM 6.4) and 25 other tissues See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ZNF627 in Genome Data Viewer
Location:
19p13.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11597483..11619161)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11725009..11747346)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11708298..11729976)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11687946-11688558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11688559-11689170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14027 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:11692934-11693099 Neighboring gene acid phosphatase 5, tartrate resistant Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14029 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 76 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10122 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11708237-11709235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10124 Neighboring gene MPRA-validated peak3358 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11734453-11734953 Neighboring gene vomeronasal 2 receptor 12 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10125 Neighboring gene zinc finger protein 887, pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The SNP rs4804611 in ZNF627 gene and the risk of myocardial infarction: a meta-analysis. Wu N, et al. Int J Clin Exp Med, 2015. PMID 26131132, Free PMC Article
  2. [Isolation of novel expression sequences of C2H2 type zinc finger protein gene from human brain tissue according to the conservation of zinc finger motif]. Sun XY, et al. Shi Yan Sheng Wu Xue Bao, 1998 Dec. PMID 12016960
  3. Genetic risk for myocardial infarction determined by polymorphisms of candidate genes in a Japanese population. Yamada Y, et al. J Med Genet, 2008 Apr. PMID 18077766
  4. Associations with myocardial infarction of six polymorphisms selected from a three-stage genome-wide association study. Horne BD, et al. Am Heart J, 2007 Nov. PMID 17967605
  5. Variations of specific non-candidate genes and risk of myocardial infarction: a replication study. Koch W, et al. Int J Cardiol, 2011 Feb 17. PMID 19709766

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Variations of specific non-candidate genes and risk of myocardial infarction: a replication study.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ90365

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 627

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290083.2 → NP_001277012.1  zinc finger protein 627 isoform 2

    See identical proteins and their annotated locations for NP_001277012.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC104527, AK074846, BC069232, DB158202
    UniProtKB/Swiss-Prot
    Q7L945
    Conserved Domains (3) summary
    COG5048
    Location:142 → 350
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:333 → 353
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:345 → 370
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001290084.3 → NP_001277013.1  zinc finger protein 627 isoform 3

    See identical proteins and their annotated locations for NP_001277013.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AK074846, AK095639, BC069232
    UniProtKB/Swiss-Prot
    Q7L945
    Conserved Domains (3) summary
    COG5048
    Location:64 → 272
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:255 → 275
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:267 → 292
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001290085.2 → NP_001277014.1  zinc finger protein 627 isoform 3

    See identical proteins and their annotated locations for NP_001277014.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 3' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AC104527, AK074846, BC069232, DA786363
    UniProtKB/Swiss-Prot
    Q7L945
    Conserved Domains (3) summary
    COG5048
    Location:64 → 272
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:255 → 275
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:267 → 292
    zf-H2C2_2; Zinc-finger double domain

  4. NM_145295.4 → NP_660338.1  zinc finger protein 627 isoform 1

    See identical proteins and their annotated locations for NP_660338.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC104527, AK074846, BC069232, BC098416
    Consensus CDS
    CCDS42502.1
    UniProtKB/Swiss-Prot
    O14846, Q4KMP9, Q6NT81, Q7L945, Q9BRG4
    Related
    ENSP00000354414.4, ENST00000361113.10
    Conserved Domains (5) summary
    smart00349
    Location:4 → 46
    KRAB; krueppel associated box
    COG5048
    Location:174 → 382
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365 → 385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:377 → 402
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    11597483..11619161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438385.1 → XP_047294341.1  zinc finger protein 627 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    11725009..11747346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320152.1 → XP_054176127.1  zinc finger protein 627 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7L945.1 GenPept UniProtKB/Swiss-Prot:Q7L945

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous