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ELAVL2 ELAV like RNA binding protein 2 [ Homo sapiens (human) ]

Gene ID: 1993, updated on 3-Apr-2024

Summary

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Official Symbol
ELAVL2provided by HGNC
Official Full Name
ELAV like RNA binding protein 2provided by HGNC
Primary source
HGNC:HGNC:3313
See related
Ensembl:ENSG00000107105 MIM:601673; AllianceGenome:HGNC:3313
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HUB; HELN1; HEL-N1
Summary
In humans, the ELAV like RNA binding protein gene family has four members (ELAVL1-4). ELAVL RNA binding proteins recognize AU-rich elements in the 3' UTRs of gene transcripts and thereby regulate gene expression post-transcriptionally. The protein encoded by this gene binds to several 3' UTRs, including its own and also that of FOS, ID, and POU5F1. This gene encodes ELAVL2 and, like ELAVL3 and ELAVL4, is expressed specifically in neurons and primarily localizes to the cytoplasm. This protein also forms a cytosolic complex with the normally nuclear-localized ELAVL1 protein. Alternative splicing of this gene results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Jul 2020]
Expression
Biased expression in testis (RPKM 13.9) and brain (RPKM 8.2) See more
Orthologs
mouse all
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Genomic context

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Location:
9p21.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (23690104..23850601, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (23696100..23856586, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (23690102..23850599, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929563 Neighboring gene SUMO2 pseudogene 2 Neighboring gene NOP56 ribonucleoprotein pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:23747173-23747672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:23820186-23821072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:23821073-23821958 Neighboring gene uncharacterized LOC105375992 Neighboring gene NANOG hESC enhancer GRCh37_chr9:23831326-23831828 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19816 Neighboring gene uncharacterized LOC105375993 Neighboring gene zinc finger protein 791 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of Hub Genes of Lung Adenocarcinoma Based on Weighted Gene Co-Expression Network in Chinese Population. Xie Y, et al. Pathol Oncol Res, 2022. PMID 36032660, Free PMC Article
  2. Bioinformatic Analysis Identified Hub Genes Associated with Heterocyclic Amines Induced Cytotoxicity of Peripheral Blood Mononuclear Cells. Li X, et al. Genes (Basel), 2021 Nov 25. PMID 34946837, Free PMC Article
  3. Targeting hub genes and pathways of innate immune response in COVID-19: A network biology perspective. Prasad K, et al. Int J Biol Macromol, 2020 Nov 15. PMID 32599245, Free PMC Article
  4. The neural ELAVL protein HuB enhances endogenous proto-oncogene activation. Hatanaka T, et al. Biochem Biophys Res Commun, 2019 Sep 17. PMID 31358321
  5. ELAVL2-regulated transcriptional and splicing networks in human neurons link neurodevelopment and autism. Berto S, et al. Hum Mol Genet, 2016 Jun 15. PMID 27260404, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Analysis of Enrichment Pathway, Hub Gene, and Protein-Protein Interaction Network in Rheumatoid Arthritis and Construction of Molecular Subtypes in Peripheral Blood.
    Title: Analysis of Enrichment Pathway, Hub Gene, and Protein-Protein Interaction Network in Rheumatoid Arthritis and Construction of Molecular Subtypes in Peripheral Blood.
  2. Identification of Hub Genes Associated with Resistance to Prednisolone in Acute Lymphoblastic Leukemia Based on Weighted Gene Co-expression Network Analysis.
    Title: Identification of Hub Genes Associated with Resistance to Prednisolone in Acute Lymphoblastic Leukemia Based on Weighted Gene Co-expression Network Analysis.
  3. Identification of Hub Genes of Lung Adenocarcinoma Based on Weighted Gene Co-Expression Network in Chinese Population.
    Title: Identification of Hub Genes of Lung Adenocarcinoma Based on Weighted Gene Co-Expression Network in Chinese Population.
  4. Bioinformatic Analysis Identified Hub Genes Associated with Heterocyclic Amines Induced Cytotoxicity of Peripheral Blood Mononuclear Cells.
    Title: Bioinformatic Analysis Identified Hub Genes Associated with Heterocyclic Amines Induced Cytotoxicity of Peripheral Blood Mononuclear Cells.
  5. HuB and HuD repress telomerase activity by dissociating HuR from TERC.
    Title: HuB and HuD repress telomerase activity by dissociating HuR from TERC.
  6. Targeting hub genes and pathways of innate immune response in COVID-19: A network biology perspective.
    Title: Targeting hub genes and pathways of innate immune response in COVID-19: A network biology perspective.
  7. HuB plays a major role in the activation of proto-oncogenes.
    Title: The neural ELAVL protein HuB enhances endogenous proto-oncogene activation.
  8. ELAVL2-regulated co-expression networks are also enriched for neurodevelopmental and synaptic genes, and include genes with human-specific patterns of expression in the frontal pole. Together, these data suggest that ELAVL2 regulation of transcript expression is critical for neuronal function and clinically relevant to autism
    Title: ELAVL2-regulated transcriptional and splicing networks in human neurons link neurodevelopment and autism.
  9. Tests for gene-environment interaction between these 33 genes and maternal smoking found evidence for interaction with two additional genes: GRID2 and ELAVL2 among European mothers
    Title: Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study.
  10. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: A Bayesian approach to genetic association studies with family-based designs.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2018-11-28)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated 2018-11-28)

ClinGen Genome Curation PagePubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables mRNA 3'-UTR binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ELAV-like protein 2
Names
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
ELAV like neuron-specific RNA binding protein 2
hu-antigen B
nervous system-specific RNA-binding protein Hel-N1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016425.3 RefSeqGene

    Range
    29361..165497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001171195.2 → NP_001164666.1  ELAV-like protein 2 isoform b

    See identical proteins and their annotated locations for NP_001164666.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2, 3, 26, 27 and 28 encode the same isoform (b).
    Source sequence(s)
    AL161628, AL445623
    Consensus CDS
    CCDS55298.1
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 345
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  2. NM_001171197.2 → NP_001164668.1  ELAV-like protein 2 isoform b

    See identical proteins and their annotated locations for NP_001164668.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2, 3, 26, 27 and 28 encode the same isoform (b).
    Source sequence(s)
    AL161628, AL445623
    Consensus CDS
    CCDS55298.1
    UniProtKB/TrEMBL
    B7Z5E0
    Related
    ENSP00000223951.5, ENST00000223951.10
    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 345
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  3. NM_001351455.2 → NP_001338384.1  ELAV-like protein 2 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL445623
    Consensus CDS
    CCDS87645.1
    UniProtKB/TrEMBL
    A0A0A0MRX1, B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:65 → 388
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  4. NM_001351456.2 → NP_001338385.1  ELAV-like protein 2 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL365204, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:65 → 387
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  5. NM_001351457.2 → NP_001338386.1  ELAV-like protein 2 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:65 → 387
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  6. NM_001351458.2 → NP_001338387.1  ELAV-like protein 2 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:65 → 387
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  7. NM_001351459.2 → NP_001338388.1  ELAV-like protein 2 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:65 → 387
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  8. NM_001351460.2 → NP_001338389.1  ELAV-like protein 2 isoform e

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL365204, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:64 → 387
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  9. NM_001351461.2 → NP_001338390.1  ELAV-like protein 2 isoform e

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:64 → 387
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  10. NM_001351462.2 → NP_001338391.1  ELAV-like protein 2 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL365204, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:64 → 386
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  11. NM_001351463.2 → NP_001338392.1  ELAV-like protein 2 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:64 → 386
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  12. NM_001351464.2 → NP_001338393.1  ELAV-like protein 2 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:65 → 374
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  13. NM_001351465.2 → NP_001338394.1  ELAV-like protein 2 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:65 → 374
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  14. NM_001351466.2 → NP_001338395.1  ELAV-like protein 2 isoform h

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL365204, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:50 → 372
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  15. NM_001351467.2 → NP_001338396.1  ELAV-like protein 2 isoform i

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 359
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  16. NM_001351468.2 → NP_001338397.1  ELAV-like protein 2 isoform i

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 359
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  17. NM_001351469.2 → NP_001338398.1  ELAV-like protein 2 isoform i

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 359
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  18. NM_001351470.2 → NP_001338399.1  ELAV-like protein 2 isoform i

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 359
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  19. NM_001351471.2 → NP_001338400.1  ELAV-like protein 2 isoform i

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 359
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  20. NM_001351472.2 → NP_001338401.1  ELAV-like protein 2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant differs in the 5' UTR compared to variant 1. Variants 1, 21, 22, 23, 24, 25 and 38 encode the same protein (isoform a).
    Source sequence(s)
    AL161628, AL445623
    Consensus CDS
    CCDS6515.1
    UniProtKB/Swiss-Prot
    D3DRK3, Q12926, Q13235, Q59G15, Q8NEM4, Q9H1Q8
    UniProtKB/TrEMBL
    B7Z5E0
    Related
    ENSP00000369460.1, ENST00000380117.5
    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 358
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  21. NM_001351473.2 → NP_001338402.1  ELAV-like protein 2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22) differs in the 5' UTR compared to variant 1. Variants 1, 21, 22, 23, 24, 25 and 38 encode the same protein (isoform a).
    Source sequence(s)
    AL161628, AL445623
    Consensus CDS
    CCDS6515.1
    UniProtKB/Swiss-Prot
    D3DRK3, Q12926, Q13235, Q59G15, Q8NEM4, Q9H1Q8
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 358
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  22. NM_001351474.2 → NP_001338403.1  ELAV-like protein 2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23) differs in the 5' UTR compared to variant 1. Variants 1, 21, 22, 23, 24, 25 and 38 encode the same protein (isoform a).
    Source sequence(s)
    AL161628, AL445623
    Consensus CDS
    CCDS6515.1
    UniProtKB/Swiss-Prot
    D3DRK3, Q12926, Q13235, Q59G15, Q8NEM4, Q9H1Q8
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 358
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  23. NM_001351475.2 → NP_001338404.1  ELAV-like protein 2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24) differs in the 5' UTR compared to variant 1. Variants 1, 21, 22, 23, 24, 25 and 38 encode the same protein (isoform a).
    Source sequence(s)
    AL161628, AL445623
    Consensus CDS
    CCDS6515.1
    UniProtKB/Swiss-Prot
    D3DRK3, Q12926, Q13235, Q59G15, Q8NEM4, Q9H1Q8
    UniProtKB/TrEMBL
    B7Z5E0
    Related
    ENSP00000440998.1, ENST00000544538.5
    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 358
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  24. NM_001351476.2 → NP_001338405.1  ELAV-like protein 2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25) differs in the 5' UTR compared to variant 1. Variants 1, 21, 22, 23, 24, 25 and 38 encode the same protein (isoform a).
    Source sequence(s)
    AL161628, AL445623
    Consensus CDS
    CCDS6515.1
    UniProtKB/Swiss-Prot
    D3DRK3, Q12926, Q13235, Q59G15, Q8NEM4, Q9H1Q8
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 358
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  25. NM_001351477.2 → NP_001338406.1  ELAV-like protein 2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2, 3, 26, 27 and 28 encode the same isoform (b).
    Source sequence(s)
    AL161628, AL445623
    Consensus CDS
    CCDS55298.1
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 345
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  26. NM_001351478.2 → NP_001338407.1  ELAV-like protein 2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2, 3, 26, 27 and 28 encode the same isoform (b).
    Source sequence(s)
    AL161628, AL445623
    Consensus CDS
    CCDS55298.1
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 345
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  27. NM_001385693.1 → NP_001372622.1  ELAV-like protein 2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: Transcript Variant: This variant (27) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2, 3, 26, 27 and 28 encode the same isoform (b).
    Source sequence(s)
    AL161628, AL445623
    Consensus CDS
    CCDS55298.1
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 345
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  28. NM_001385694.1 → NP_001372623.1  ELAV-like protein 2 isoform j

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL365204, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:50 → 360
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  29. NM_001385695.1 → NP_001372624.1  ELAV-like protein 2 isoform k

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL365204, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:65 → 375
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  30. NM_001385696.1 → NP_001372625.1  ELAV-like protein 2 isoform m

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL365204, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:50 → 373
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  31. NM_001385697.1 → NP_001372626.1  ELAV-like protein 2 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL445623
    Consensus CDS
    CCDS87645.1
    UniProtKB/TrEMBL
    A0A0A0MRX1, B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:65 → 388
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  32. NM_001385698.1 → NP_001372627.1  ELAV-like protein 2 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL445623
    Consensus CDS
    CCDS87645.1
    UniProtKB/TrEMBL
    A0A0A0MRX1, B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:65 → 388
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  33. NM_001385699.1 → NP_001372628.1  ELAV-like protein 2 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:65 → 387
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  34. NM_001385700.1 → NP_001372629.1  ELAV-like protein 2 isoform e

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:64 → 387
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  35. NM_001385701.1 → NP_001372630.1  ELAV-like protein 2 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:65 → 374
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  36. NM_001385702.1 → NP_001372631.1  ELAV-like protein 2 isoform i

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 359
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  37. NM_001385703.1 → NP_001372632.1  ELAV-like protein 2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: Transcript Variant: This variant (25) differs in the 5' UTR compared to variant 1. Variants 1, 21, 22, 23, 24, 25 and 38 encode the same protein (isoform a).
    Source sequence(s)
    AL161628, AL445623
    Consensus CDS
    CCDS6515.1
    UniProtKB/Swiss-Prot
    D3DRK3, Q12926, Q13235, Q59G15, Q8NEM4, Q9H1Q8
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 358
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  38. NM_001385704.1 → NP_001372633.1  ELAV-like protein 2 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL445623
    Consensus CDS
    CCDS87645.1
    UniProtKB/TrEMBL
    A0A0A0MRX1, B7Z5E0
    Related
    ENSP00000369453.4, ENST00000380110.8
    Conserved Domains (1) summary
    TIGR01661
    Location:65 → 388
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  39. NM_001385705.1 → NP_001372634.1  ELAV-like protein 2 isoform i

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 359
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  40. NM_001385707.1 → NP_001372636.1  ELAV-like protein 2 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL161628, AL445623
    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:65 → 387
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  41. NM_004432.5 → NP_004423.2  ELAV-like protein 2 isoform a

    See identical proteins and their annotated locations for NP_004423.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform (a). Variants 1, 21, 22, 23, 24, 25 and 38 encode the same protein (isoform a).
    Source sequence(s)
    AL161628, AL445623
    Consensus CDS
    CCDS6515.1
    UniProtKB/Swiss-Prot
    D3DRK3, Q12926, Q13235, Q59G15, Q8NEM4, Q9H1Q8
    UniProtKB/TrEMBL
    B7Z5E0
    Related
    ENSP00000380479.2, ENST00000397312.7
    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 358
    ELAV_HUD_SF; ELAV/HuD family splicing factor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    23690104..23850601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422916.1 → XP_047278872.1  ELAV-like protein 2 isoform X11

  2. XM_011517779.4 → XP_011516081.1  ELAV-like protein 2 isoform X7

    See identical proteins and their annotated locations for XP_011516081.1

    UniProtKB/TrEMBL
    A0A0A0MRX1, B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:65 → 388
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  3. XM_047422917.1 → XP_047278873.1  ELAV-like protein 2 isoform X12

  4. XM_011517778.3 → XP_011516080.2  ELAV-like protein 2 isoform X6

    UniProtKB/TrEMBL
    B7Z5E0

  5. XM_047422910.1 → XP_047278866.1  ELAV-like protein 2 isoform X3

  6. XM_047422909.1 → XP_047278865.1  ELAV-like protein 2 isoform X2

  7. XM_047422908.1 → XP_047278864.1  ELAV-like protein 2 isoform X1

  8. XM_047422911.1 → XP_047278867.1  ELAV-like protein 2 isoform X4

  9. XM_047422915.1 → XP_047278871.1  ELAV-like protein 2 isoform X10

  10. XM_017014415.2 → XP_016869904.1  ELAV-like protein 2 isoform X9

    UniProtKB/TrEMBL
    B7Z5E0

  11. XM_047422914.1 → XP_047278870.1  ELAV-like protein 2 isoform X8

  12. XM_011517786.3 → XP_011516088.1  ELAV-like protein 2 isoform X12

    See identical proteins and their annotated locations for XP_011516088.1

    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 359
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  13. XM_005251393.4 → XP_005251450.1  ELAV-like protein 2 isoform X12

    See identical proteins and their annotated locations for XP_005251450.1

    UniProtKB/TrEMBL
    B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 359
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  14. XM_011517780.4 → XP_011516082.1  ELAV-like protein 2 isoform X7

    See identical proteins and their annotated locations for XP_011516082.1

    UniProtKB/TrEMBL
    A0A0A0MRX1, B7Z5E0
    Conserved Domains (1) summary
    TIGR01661
    Location:65 → 388
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  15. XM_047422912.1 → XP_047278868.1  ELAV-like protein 2 isoform X5

  16. XM_017014426.2 → XP_016869915.1  ELAV-like protein 2 isoform X15

    Conserved Domains (1) summary
    TIGR01661
    Location:1 → 224
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  17. XM_047422918.1 → XP_047278874.1  ELAV-like protein 2 isoform X13

  18. XM_047422920.1 → XP_047278876.1  ELAV-like protein 2 isoform X14

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    23696100..23856586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362248.1 → XP_054218223.1  ELAV-like protein 2 isoform X11

  2. XM_054362243.1 → XP_054218218.1  ELAV-like protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A0A0MRX1

  3. XM_054362250.1 → XP_054218225.1  ELAV-like protein 2 isoform X12

  4. XM_054362242.1 → XP_054218217.1  ELAV-like protein 2 isoform X6

  5. XM_054362239.1 → XP_054218214.1  ELAV-like protein 2 isoform X3

  6. XM_054362238.1 → XP_054218213.1  ELAV-like protein 2 isoform X2

  7. XM_054362237.1 → XP_054218212.1  ELAV-like protein 2 isoform X1

  8. XM_054362240.1 → XP_054218215.1  ELAV-like protein 2 isoform X4

  9. XM_054362247.1 → XP_054218222.1  ELAV-like protein 2 isoform X10

  10. XM_054362246.1 → XP_054218221.1  ELAV-like protein 2 isoform X9

  11. XM_054362245.1 → XP_054218220.1  ELAV-like protein 2 isoform X8

  12. XM_054362244.1 → XP_054218219.1  ELAV-like protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A0A0MRX1

  13. XM_054362251.1 → XP_054218226.1  ELAV-like protein 2 isoform X12

  14. XM_054362249.1 → XP_054218224.1  ELAV-like protein 2 isoform X12

  15. XM_054362241.1 → XP_054218216.1  ELAV-like protein 2 isoform X5

  16. XM_054362254.1 → XP_054218229.1  ELAV-like protein 2 isoform X15

  17. XM_054362252.1 → XP_054218227.1  ELAV-like protein 2 isoform X13

  18. XM_054362253.1 → XP_054218228.1  ELAV-like protein 2 isoform X14

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12926.2 GenPept UniProtKB/Swiss-Prot:Q12926

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