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Slc22a8 solute carrier family 22 (organic anion transporter), member 8 [ Mus musculus (house mouse) ]

Gene ID: 19879, updated on 2-Nov-2024

Summary

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Official Symbol
Slc22a8provided by MGI
Official Full Name
solute carrier family 22 (organic anion transporter), member 8provided by MGI
Primary source
MGI:MGI:1336187
See related
Ensembl:ENSMUSG00000063796 AllianceGenome:MGI:1336187
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Oat3; Roct
Summary
Enables antiporter activity and organic anion transmembrane transporter activity. Predicted to be involved in glutathione transport; prostaglandin transport; and quaternary ammonium group transport. Predicted to be located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; liver; spleen; and thyroid gland. Orthologous to human SLC22A8 (solute carrier family 22 member 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward kidney adult (RPKM 202.2) See more
Orthologs
human all
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Genomic context

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See Slc22a8 in Genome Data Viewer
Location:
19 A; 19 5.44 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8568576..8589199)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8591254..8611835)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57666 Neighboring gene solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 pseudogene Neighboring gene predicted gene, 36394 Neighboring gene solute carrier family 22 (organic anion transporter), member 6 Neighboring gene RIKEN cDNA 9830166K06 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Organic anion transporter 3 (oat3/slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin. Vanwert AL, et al. Mol Pharmacol, 2008 Jul. PMID 18381565, Free PMC Article
  2. Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Kobayashi Y, et al. Drug Metab Dispos, 2004 May. PMID 15100168
  3. Organic anion transport in choroid plexus from wild-type and organic anion transporter 3 (Slc22a8)-null mice. Sykes D, et al. Am J Physiol Renal Physiol, 2004 May. PMID 15075193
  4. Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways. Wu W, et al. Drug Metab Dispos, 2013 Oct. PMID 23920220, Free PMC Article
  5. Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. Ohtsuki S, et al. J Pharmacol Exp Ther, 2004 Jun. PMID 14762099

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3.
    Title: Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3.
  2. Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease.
    Title: Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease.
  3. Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning.
    Title: Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning.
  4. OAT3 increases the glucosuric effect of empagliflozin, which may relate to the partial overlap of its localization with SGLT2 and thus OAT3-mediated tubular secretion of empagliflozin in the early proximal tubule.
    Title: Organic anion transporter OAT3 enhances the glucosuric effect of the SGLT2 inhibitor empagliflozin.
  5. vitamin D-deficiency resulted in down-regulation of liver Cyp7a1 and renal Oat3, conditions that are alleviated upon replenishment of cholecalciferol.
    Title: Alterations in gene expression in vitamin D-deficiency: Down-regulation of liver Cyp7a1 and renal Oat3 in mice.
  6. OCT2-independent pathway of cisplatin-induced renal injury that is mediated by the organic anion transporters OAT1 and OAT3, is reported.
    Title: Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity.
  7. OAT1 plays a greater role in kidney proximal tubule metabolism and OAT3 appears relatively more important in systemic metabolism, modulating levels of metabolites flowing through intestine, liver, and kidney
    Title: The drug transporter OAT3 (SLC22A8) and endogenous metabolite communication via the gut-liver-kidney axis.
  8. Arsenic and mercury containing traditional Chinese medicine (Realgar and Cinnabar) probably induce kidney damage through inhibiting several members of the organic anion transporters (such as OAT1 and OAT3).
    Title: Arsenic and Mercury Containing Traditional Chinese Medicine (Realgar and Cinnabar) Strongly Inhibit Organic Anion Transporters, Oat1 and Oat3, In Vivo in Mice.
  9. Specifically blocking its transport through OAT3 or antioxidant treatment could prevent CMPF-induced beta cell dysfunction.
    Title: The furan fatty acid metabolite CMPF is elevated in diabetes and induces β cell dysfunction.
  10. Oat3 also plays a role in bioenergetic pathways.
    Title: Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables organic anion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables organic anion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables organic anion transmembrane transporter activity TAS
Traceable Author Statement
more info
  
enables prostaglandin transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables prostaglandin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
  
enables quaternary ammonium group transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables solute:inorganic anion antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables solute:inorganic anion antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables xenobiotic transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables xenobiotic transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in glutathione transport ISO
Inferred from Sequence Orthology
more info
  
involved_in inorganic anion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in prostaglandin transport ISO
Inferred from Sequence Orthology
more info
  
involved_in prostaglandin transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in quaternary ammonium group transport ISO
Inferred from Sequence Orthology
more info
  
involved_in response to toxic substance IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
organic anion transporter 3
Names
organic anion/dicarboxylate exchanger
reduced in osteosclerosis transporter
solute carrier family 22, member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164634.2 → NP_001158106.1  organic anion transporter 3 isoform 1

    See identical proteins and their annotated locations for NP_001158106.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC025794, AC125136
    Consensus CDS
    CCDS29537.1
    UniProtKB/Swiss-Prot
    O88909, Q3TZF9, Q8CCX3, Q8CFH5, Q91WJ9
    Related
    ENSMUSP00000131045.2, ENSMUST00000170817.2
    Conserved Domains (1) summary
    TIGR00898
    Location:11 → 503
    2A0119; cation transport protein

  2. NM_001164635.2 → NP_001158107.1  organic anion transporter 3 isoform 1

    See identical proteins and their annotated locations for NP_001158107.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC025794, AC125136
    Consensus CDS
    CCDS29537.1
    UniProtKB/Swiss-Prot
    O88909, Q3TZF9, Q8CCX3, Q8CFH5, Q91WJ9
    Conserved Domains (1) summary
    TIGR00898
    Location:11 → 503
    2A0119; cation transport protein

  3. NM_001411470.1 → NP_001398399.1  organic anion transporter 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC025794, AC125136
    UniProtKB/Swiss-Prot
    O88909, Q3TZF9, Q8CCX3, Q8CFH5, Q91WJ9

  4. NM_001411471.1 → NP_001398400.1  organic anion transporter 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC025794, AC125136

  5. NM_001411472.1 → NP_001398401.1  organic anion transporter 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC025794, AC125136

  6. NM_001411473.1 → NP_001398402.1  organic anion transporter 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC025794, AC125136

  7. NM_031194.6 → NP_112471.3  organic anion transporter 3 isoform 1

    See identical proteins and their annotated locations for NP_112471.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC025794, AC125136
    Consensus CDS
    CCDS29537.1
    UniProtKB/Swiss-Prot
    O88909, Q3TZF9, Q8CCX3, Q8CFH5, Q91WJ9
    Related
    ENSMUSP00000010251.4, ENSMUST00000010251.11
    Conserved Domains (1) summary
    TIGR00898
    Location:11 → 503
    2A0119; cation transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    8568576..8589199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004940127.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88909.2 GenPept UniProtKB/Swiss-Prot:O88909

Gene LinkOut

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