U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LKAAEAR1 LKAAEAR motif containing 1 [ Homo sapiens (human) ]

Gene ID: 198437, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
LKAAEAR1provided by HGNC
Official Full Name
LKAAEAR motif containing 1provided by HGNC
Primary source
HGNC:HGNC:33718
See related
Ensembl:ENSG00000171695 AllianceGenome:HGNC:33718
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C20orf201
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LKAAEAR1 in Genome Data Viewer
Location:
20q13.33
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (64083376..64084953, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (65903431..65905008, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62714729..62716306, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62686363-62687052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62687053-62687742 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62688433-62689122 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62689123-62689810 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18263 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13205 Neighboring gene transcription elongation factor A2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13206 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13207 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:62711846-62712019 Neighboring gene regulator of G protein signaling 19 Neighboring gene microRNA 6813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13209 Neighboring gene MPRA-validated peak4324 silencer Neighboring gene opioid related nociceptin receptor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62723260-62723993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62723994-62724726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62732783-62733284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62738466-62738966 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:62740950-62741133 Neighboring gene neuropeptides B and W receptor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62751601-62752100 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:62754467-62755666 Neighboring gene B6.7 minisatellite repeat instability region Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62768655-62769156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62769157-62769656 Neighboring gene uncharacterized LOC105372727 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62771493-62772406

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

General protein information

Go to the top of the page Help
Preferred Names
protein LKAAEAR1
Names
LKAAEAR motif-containing protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007125.3 → NP_001007126.1  protein LKAAEAR1 isoform 1

    See identical proteins and their annotated locations for NP_001007126.1

    Status: VALIDATED

    Source sequence(s)
    AL590548
    Consensus CDS
    CCDS33509.1
    UniProtKB/Swiss-Prot
    Q8TD35
    Related
    ENSP00000310801.2, ENST00000308906.6
    Conserved Domains (1) summary
    pfam15478
    Location:40 → 175
    LKAAEAR; Family of unknown function with LKAAEAR motif

  2. NM_001353425.2 → NP_001340354.1  protein LKAAEAR1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL590548
    Consensus CDS
    CCDS86972.1
    UniProtKB/Swiss-Prot
    Q8N419, Q8TD35, Q8TD36
    Related
    ENSP00000302763.4, ENST00000302096.5
    Conserved Domains (1) summary
    pfam15478
    Location:40 → 175
    LKAAEAR; Family of unknown function with LKAAEAR motif

  3. NM_001386971.1 → NP_001373900.1  protein LKAAEAR1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL590548
    Consensus CDS
    CCDS86972.1
    UniProtKB/Swiss-Prot
    Q8N419, Q8TD35, Q8TD36
    Conserved Domains (1) summary
    pfam15478
    Location:40 → 175
    LKAAEAR; Family of unknown function with LKAAEAR motif

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    64083376..64084953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451849.2 → XP_024307617.1  protein LKAAEAR1 isoform X1

    Conserved Domains (1) summary
    pfam15478
    Location:40 → 175
    LKAAEAR; Family of unknown function with LKAAEAR motif

  2. XM_047439963.1 → XP_047295919.1  protein LKAAEAR1 isoform X2

    UniProtKB/Swiss-Prot
    Q8N419, Q8TD35, Q8TD36

  3. XM_024451850.2 → XP_024307618.1  protein LKAAEAR1 isoform X1

    Conserved Domains (1) summary
    pfam15478
    Location:40 → 175
    LKAAEAR; Family of unknown function with LKAAEAR motif

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    65903431..65905008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TD35.3 GenPept UniProtKB/Swiss-Prot:Q8TD35

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous