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PIG-Z Phosphatidylinositol glycan anchor biosynthesis class Z [ Drosophila melanogaster (fruit fly) ]

Gene ID: 19835548, updated on 18-Sep-2024

Summary

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Official Symbol
PIG-Zprovided by FlyBase
Official Full Name
Phosphatidylinositol glycan anchor biosynthesis class Zprovided by FlyBase
Primary source
FLYBASE:FBgn0266438
Locus tag
Dmel_CG45068
See related
AllianceGenome:FB:FBgn0266438
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3419; CG45068; Dmel\CG45068; PIGZ
Summary
Predicted to enable alpha-1,2-mannosyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Orthologous to human PIGZ (phosphatidylinositol glycan anchor biosynthesis class Z). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See PIG-Z in Genome Data Viewer
Location:
60C8-60C8; 2-106 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24411870..24415295)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20299393..20302818)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Sterile20-like kinase Neighboring gene Regulatory particle non-ATPase 8 Neighboring gene Serotonin transporter Neighboring gene uncharacterized protein Neighboring gene prominin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The essential Smp3 protein is required for addition of the side-branching fourth mannose during assembly of yeast glycosylphosphatidylinositols. Grimme SJ, et al. J Biol Chem, 2001 Jul 20. PMID 11356840
  2. Eyes closed, a Drosophila p47 homolog, is essential for photoreceptor morphogenesis. Sang TK, et al. Development, 2002 Jan. PMID 11782408
  3. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article
  4. NCBP2 modulates neurodevelopmental defects of the 3q29 deletion in Drosophila and Xenopus laevis models. Singh MD, et al. PLoS Genet, 2020 Feb. PMID 32053595, Free PMC Article
  5. GPI biosynthesis is essential for rhodopsin sorting at the trans-Golgi network in Drosophila photoreceptors. Satoh T, et al. Development, 2013 Jan 15. PMID 23250212

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alpha-1,2-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-1,2-mannosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidylinositol glycan anchor biosynthesis class Z
Names
CG45068-PA
PIG-Z-PA
NP_001286840.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24411870..24415295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299911.1 → NP_001286840.1  phosphatidylinositol glycan anchor biosynthesis class Z [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286840.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4LGH6, Q8MT80, Q9W176
    Conserved Domains (1) summary
    pfam03901
    Location:18 → 541
    Glyco_transf_22; Alg9-like mannosyltransferase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MT80.1 Q8MT80

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous