Ring1 ring finger protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ring1provided by MGI
Official Full Name: ring finger protein 1provided by MGI
Primary source: MGI:MGI:1101770
See related: Ensembl:ENSMUSG00000024325 AllianceGenome:MGI:1101770
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ring1A
Summary: Enables chromatin binding activity and ubiquitin-protein transferase activator activity. Acts upstream of or within with a positive effect on chromatin organization. Acts upstream of or within anterior/posterior pattern specification; camera-type eye morphogenesis; and negative regulation of DNA-templated transcription. Located in nuclear body and sex chromatin. Part of PRC1 complex. Is expressed in several structures, including central nervous system; hemolymphoid system gland; liver; reproductive system; and urinary system. Orthologous to human RING1 (ring finger protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 28.8), adrenal adult (RPKM 26.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34239766..34243654, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (34020792..34024680, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ring1a protects against colitis through regulating mucosal immune system and colonic microbial ecology.
Title: Ring1a protects against colitis through regulating mucosal immune system and colonic microbial ecology.
Essential role of MESP1-RING1A complex in cardiac differentiation.
Title: Essential role of MESP1-RING1A complex in cardiac differentiation.
The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon.
Title: The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon.
Polycomb Repressive Complex 1 Controls Maintenance of Fungiform Papillae by Repressing Sonic Hedgehog Expression.
Title: Polycomb Repressive Complex 1 Controls Maintenance of Fungiform Papillae by Repressing Sonic Hedgehog Expression.
Ring1A/B regulate and maintain AML stem cells in part by repressing Glis2 expression, which promotes their differentiation.
Title: Ring1A and Ring1B inhibit expression of Glis2 to maintain murine MOZ-TIF2 AML stem cells.
Data suggest that the RING1-MEIS1/2 axis is regulated by early PD signals and contributes to the initiation or maintenance of the distal signal circuitry.
Title: RING1 proteins contribute to early proximal-distal specification of the forelimb bud by restricting Meis2 expression.
identification of gene-dosage-dependent roles in primordial germ cell development for Ring1 and Rnf2, two central components of the Polycomb repressive complex 1 (PRC1)
Title: PRC1 coordinates timing of sexual differentiation of female primordial germ cells.
loss of Ring1a/b postnatally results in defective cervical loops and disturbances of enamel and dentin formation in continuously growing incisors
Title: Ring1a/b polycomb proteins regulate the mesenchymal stem cell niche in continuously growing incisors.
Studies in mammalian cells have found a multiplicity of protein complexes containing Ring1A and Ring1B, suggesting an expanded regulatory role for Ring1A, Ring1B proteins in the epigenetic regulation of gene expression.
Title: Role of polycomb proteins Ring1A and Ring1B in the epigenetic regulation of gene expression.
Ring1A/B-mediated Polycomb silencing functions downstream of the core transcriptional regulatory circuitry to maintain ES cell identity
Title: Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ring1 (e-PCR), detects polymorphism
- UniSTS:463426

Y12881 (e-PCR)
- UniSTS:160650

MARC_5283-5284:991939549:1 (e-PCR)
- UniSTS:231147

MARC_5283-5284:996690262:1 (e-PCR)
- UniSTS:231147

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within camera-type eye morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within_positive_effect chromatin organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within_positive_effect chromatin organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of PRC1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of PRC1 complex	ISO Inferred from Sequence Orthology more info
part_of PcG protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PcG protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of PcG protein complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in sex chromatin	IDA Inferred from Direct Assay more info	PubMed
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RING1

Names: RING-type E3 ubiquitin transferase RING1; polycomb complex protein RING1; transcription repressor Ring1A

NP_033092.3

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.