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ZNF778 zinc finger protein 778 [ Homo sapiens (human) ]

Gene ID: 197320, updated on 11-Apr-2024

Summary

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Official Symbol
ZNF778provided by HGNC
Official Full Name
zinc finger protein 778provided by HGNC
Primary source
HGNC:HGNC:26479
See related
Ensembl:ENSG00000170100 AllianceGenome:HGNC:26479
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the krueppel C2H2-type zinc-finger protein family, and it contains one KRAB domain and eighteen C2H2-type zinc fingers. This gene is a candidate gene for autism and variable cognitive impairment in the 16q24.3 microdeletion syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2011]
Expression
Ubiquitous expression in testis (RPKM 3.1), brain (RPKM 2.1) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
16q24.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (89217703..89237141)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (95297944..95317628)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (89284111..89303549)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89265225-89265848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89267097-89267719 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7895 Neighboring gene solute carrier family 22 member 31 Neighboring gene Sharpr-MPRA regulatory region 4154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11397 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89284467-89284997 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89284998-89285527 Neighboring gene ZNF778 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 2584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7896 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:89308033-89308549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7897 Neighboring gene uncharacterized LOC124903766 Neighboring gene ankyrin repeat domain containing 11 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89357571-89358417 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89360111-89360956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89360957-89361803 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89361804-89362649 Neighboring gene uncharacterized LOC105371414 Neighboring gene keratin-associated protein 5-2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of ANKRD11 and ZNF778 as candidate genes for autism and variable cognitive impairment in the novel 16q24.3 microdeletion syndrome. Willemsen MH, et al. Eur J Hum Genet, 2010 Apr. PMID 19920853, Free PMC Article
  2. ZNF768 links oncogenic RAS to cellular senescence. Villot R, et al. Nat Commun, 2021 Aug 17. PMID 34404770, Free PMC Article
  3. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
  4. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995
  5. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF768 links oncogenic RAS to cellular senescence.
    Title: ZNF768 links oncogenic RAS to cellular senescence.
  2. ZNF778 is a candidate gene for autism and variable cognitive impairment in the novel 16q24.3 microdeletion syndrome.
    Title: Identification of ANKRD11 and ZNF778 as candidate genes for autism and variable cognitive impairment in the novel 16q24.3 microdeletion syndrome.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31875, MGC150573

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 778

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028146.1 RefSeqGene

    Range
    5001..16855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_284

mRNA and Protein(s)

  1. NM_001201407.2 → NP_001188336.1  zinc finger protein 778 isoform 1

    See identical proteins and their annotated locations for NP_001188336.1

    Status: REVIEWED

    Source sequence(s)
    AC009113
    Consensus CDS
    CCDS73928.1
    UniProtKB/TrEMBL
    A0A0A0MSW5
    Related
    ENSP00000405289.3, ENST00000433976.7
    Conserved Domains (3) summary
    smart00349
    Location:42 → 100
    KRAB; krueppel associated box
    COG5048
    Location:380 → 747
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:591 → 611
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001378881.1 → NP_001365810.1  zinc finger protein 778 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC009113
    Consensus CDS
    CCDS73928.1
    UniProtKB/TrEMBL
    A0A0A0MSW5
    Related
    ENSP00000305203.6, ENST00000306502.6
    Conserved Domains (3) summary
    smart00349
    Location:42 → 100
    KRAB; krueppel associated box
    COG5048
    Location:380 → 747
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:591 → 611
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_182531.5 → NP_872337.2  zinc finger protein 778 isoform 2

    See identical proteins and their annotated locations for NP_872337.2

    Status: REVIEWED

    Source sequence(s)
    AC009113
    Consensus CDS
    CCDS45550.1
    UniProtKB/Swiss-Prot
    Q08AG0, Q96MU6
    Related
    ENSP00000481538.1, ENST00000620195.4
    Conserved Domains (5) summary
    smart00349
    Location:42 → 82
    KRAB; krueppel associated box
    COG5048
    Location:352 → 719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:563 → 583
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:42 → 81
    KRAB; KRAB box
    pfam13465
    Location:575 → 600
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_037705.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009113

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    89217703..89237141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    95297944..95317628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96MU6.3 GenPept UniProtKB/Swiss-Prot:Q96MU6

Gene LinkOut

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