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Slc50a1 solute carrier family 50 (sugar transporter), member 1 [ Mus musculus (house mouse) ]

Gene ID: 19729, updated on 2-Nov-2024

Summary

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Official Symbol
Slc50a1provided by MGI
Official Full Name
solute carrier family 50 (sugar transporter), member 1provided by MGI
Primary source
MGI:MGI:107417
See related
Ensembl:ENSMUSG00000027953 AllianceGenome:MGI:107417
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rga; Rag1ap1; MmSWEET1
Summary
Predicted to enable glucoside transmembrane transporter activity and sugar transmembrane transporter activity. Predicted to be involved in carbohydrate transport. Predicted to be located in Golgi apparatus and plasma membrane. Predicted to be active in membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Orthologous to human SLC50A1 (solute carrier family 50 member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in colon adult (RPKM 117.8), lung adult (RPKM 98.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Slc50a1 in Genome Data Viewer
Location:
3 F1; 3 39.04 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89175553..89177878, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89268246..89270591, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 46 Neighboring gene keratinocyte associated protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E4552 Neighboring gene dolichyl-phosphate mannosyltransferase polypeptide 3 Neighboring gene ephrin A1 Neighboring gene VISTA enhancer mm1415 Neighboring gene predicted gene, 33845

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Formation of a physiological complex between TRPV2 and RGA protein promotes cell surface expression of TRPV2. Stokes AJ, et al. J Cell Biochem, 2005 Mar 1. PMID 15547947
  2. RGA protein associates with a TRPV ion channel during biosynthesis and trafficking. Barnhill JC, et al. J Cell Biochem, 2004 Mar 1. PMID 14991772
  3. A physical map of the genomic region on mouse chromosome 3 containing the hindshaker (hsh) mutation. Karim SA, et al. Genomics, 2004 Feb. PMID 14706451
  4. Molecular cloning and characterization of a novel stromal cell-derived cDNA encoding a protein that facilitates gene activation of recombination activating gene (RAG)-1 in human lymphoid progenitors. Tagoh H, et al. Biochem Biophys Res Commun, 1996 Apr 25. PMID 8630032
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RGA participates in the control of transient receptor potential cation channel, subfamily V, member 2 surface levels
    Title: Formation of a physiological complex between TRPV2 and RGA protein promotes cell surface expression of TRPV2.
  2. novel protein-protein interaction with TRPV2
    Title: RGA protein associates with a TRPV ion channel during biosynthesis and trafficking.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glucoside transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables glucoside transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sugar transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sugar transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in carbohydrate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucoside transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sugar transporter SWEET1
Names
RAG1-activating protein 1
probable sugar transporter RAG1AP1
recombination activating gene 1 activating protein 1
recombination activating gene 1 gene activation
solute carrier family 50 member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410551.1 → NP_001397480.1  sugar transporter SWEET1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC132327

  2. NM_001410552.1 → NP_001397481.1  sugar transporter SWEET1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC132327

  3. NM_001410553.1 → NP_001397482.1  sugar transporter SWEET1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC132327
    Related
    ENSMUST00000148095.2

  4. NM_001410554.1 → NP_001397483.1  sugar transporter SWEET1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC132327
    Related
    ENSMUST00000144777.8

  5. NM_001410555.1 → NP_001397484.1  sugar transporter SWEET1 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC132327
    UniProtKB/TrEMBL
    D3YXA7
    Related
    ENSMUSP00000103084.2, ENSMUST00000107460.8

  6. NM_001410556.1 → NP_001397485.1  sugar transporter SWEET1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC132327

  7. NM_001410557.1 → NP_001397486.1  sugar transporter SWEET1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC132327

  8. NM_001410558.1 → NP_001397487.1  sugar transporter SWEET1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC132327

  9. NM_001410559.1 → NP_001397488.1  sugar transporter SWEET1 isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC132327

  10. NM_001410560.1 → NP_001397489.1  sugar transporter SWEET1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC132327

  11. NM_009057.4 → NP_033083.2  sugar transporter SWEET1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_033083.2

    Status: VALIDATED

    Source sequence(s)
    AC132327
    Consensus CDS
    CCDS17500.1
    UniProtKB/Swiss-Prot
    Q62275, Q9CXK4
    Related
    ENSMUSP00000029565.5, ENSMUST00000029565.11
    Conserved Domains (1) summary
    pfam03083
    Location:9 → 95
    MtN3_slv; Sugar efflux transporter for intercellular exchange

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89175553..89177878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004941298.1 RNA Sequence

    Related
    ENSMUST00000133575.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CXK4.1 GenPept UniProtKB/Swiss-Prot:Q9CXK4

Gene LinkOut

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