U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DCP1B decapping mRNA 1B [ Homo sapiens (human) ]

Gene ID: 196513, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
DCP1Bprovided by HGNC
Official Full Name
decapping mRNA 1Bprovided by HGNC
Primary source
HGNC:HGNC:24451
See related
Ensembl:ENSG00000151065 MIM:609843; AllianceGenome:HGNC:24451
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DCP1
Summary
This gene encodes a member of a family of proteins that function in removing the 5' cap from mRNAs, which is a step in regulated mRNA decay. This protein localizes to cytoplasmic foci which are the site of mRNA breakdown and turnover. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression
Broad expression in testis (RPKM 7.9), endometrium (RPKM 5.4) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See DCP1B in Genome Data Viewer
Location:
12p13.33
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (1941591..2004457, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (1937705..2000585, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (2050757..2113623, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 4 Neighboring gene uncharacterized LOC124902858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2021735-2022235 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:2025891-2026467 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:2042322-2042920 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:2063223-2064422 Neighboring gene long intergenic non-protein coding RNA 940 Neighboring gene Sharpr-MPRA regulatory region 10568 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:2112705-2113344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5813 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:2120775-2121283 Neighboring gene CACNA1C intronic transcript 1 Neighboring gene calcium voltage-gated channel subunit alpha1 C Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4127 Neighboring gene CACNA1C intronic transcript 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex. Ziemniak M, et al. RNA, 2016 Apr. PMID 26826132, Free PMC Article
  2. Cytoplasmic foci are sites of mRNA decay in human cells. Cougot N, et al. J Cell Biol, 2004 Apr. PMID 15067023, Free PMC Article
  3. Identification and characterization of protein interactions in the mammalian mRNA processing body using a novel two-hybrid assay. Bloch DB, et al. Exp Cell Res, 2011 Sep 10. PMID 21672539
  4. A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. Innocenti F, et al. Clin Cancer Res, 2012 Jan 15. PMID 22142827, Free PMC Article
  5. Retroviral GAG proteins recruit AGO2 on viral RNAs without affecting RNA accumulation and translation. Bouttier M, et al. Nucleic Acids Res, 2012 Jan. PMID 21948796, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
EBI GWAS Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with DCP1 in a miRNA- and P-body-independent manner PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme activator activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in membrane HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
mRNA-decapping enzyme 1B
Names
DCP1 decapping enzyme homolog B
decapping enzyme hDcp1b
NP_001306221.1
NP_689853.3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319292.2 → NP_001306221.1  mRNA-decapping enzyme 1B isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' coding exons and extends past a splice site used in variant 1, resulting in a different 3' coding region and 3' UTR. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC005342, AK301109, BM544996, BQ773904, BU930253, DC425587
    Consensus CDS
    CCDS81651.1
    UniProtKB/TrEMBL
    B4DVJ6
    Related
    ENSP00000482714.1, ENST00000535873.2
    Conserved Domains (1) summary
    cd09804
    Location:16 → 108
    Dcp1; mRNA decapping enzyme 1 (Dcp1)

  2. NM_152640.5 → NP_689853.3  mRNA-decapping enzyme 1B isoform 1

    See identical proteins and their annotated locations for NP_689853.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK299203, AW204088, AY146652, BC015368
    Consensus CDS
    CCDS31727.1
    UniProtKB/Swiss-Prot
    B4DRD1, Q86XH9, Q8IZD4, Q96BP8, Q96MZ8
    Related
    ENSP00000280665.6, ENST00000280665.11
    Conserved Domains (2) summary
    cd09804
    Location:16 → 131
    Dcp1; mRNA decapping enzyme 1 (Dcp1)
    pfam16741
    Location:574 → 615
    mRNA_decap_C; mRNA-decapping enzyme C-terminus

RNA

  1. NR_135060.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate internal exon and differs in the 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005342, AK299203
    Related
    ENST00000543381.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    1941591..2004457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654718.1 Reference GRCh38.p14 PATCHES

    Range
    283735..346601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    1937705..2000585 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IZD4.2 GenPept UniProtKB/Swiss-Prot:Q8IZD4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous