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EGR3 early growth response 3 [ Homo sapiens (human) ]

Gene ID: 1960, updated on 16-Apr-2024

Summary

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Official Symbol
EGR3provided by HGNC
Official Full Name
early growth response 3provided by HGNC
Primary source
HGNC:HGNC:3240
See related
Ensembl:ENSG00000179388 MIM:602419; AllianceGenome:HGNC:3240
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EGR-3; PILOT
Summary
This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]
Expression
Broad expression in gall bladder (RPKM 18.5), brain (RPKM 16.1) and 21 other tissues See more
Orthologs
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Genomic context

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See EGR3 in Genome Data Viewer
Location:
8p21.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (22687659..22693480, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (22961911..22967732, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (22545172..22550993, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986876 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:22462104-22462604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19003 Neighboring gene cell cycle and apoptosis regulator 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22483969-22484602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22485870-22486503 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22486504-22487136 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22488646-22489180 Neighboring gene bridging integrator 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22489181-22489715 Neighboring gene BIN3 intronic transcript 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22515470-22516064 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22516065-22516659 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:22526357-22526986 Neighboring gene CRISPRi-validated cis-regulatory element chr8.740 Neighboring gene uncharacterized LOC107986924 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22547791-22548696 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:22549417-22549612 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19006 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:22551019-22551182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22551227-22551872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19008 Neighboring gene uncharacterized LOC105379321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19009 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19010 Neighboring gene uncharacterized LOC107986926

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Early growth response 3 inhibits growth of hepatocellular carcinoma cells via upregulation of Fas ligand. Zhang S, et al. Int J Oncol, 2017 Mar. PMID 28098878
  2. Association of Egr3 genetic polymorphisms and coronary artery disease in the Uygur and Han of China. Li X, et al. Lipids Health Dis, 2014 May 21. PMID 24886494, Free PMC Article
  3. Association of decreased prefrontal hemodynamic response during a verbal fluency task with EGR3 gene polymorphism in patients with schizophrenia and in healthy individuals. Nishimura Y, et al. Neuroimage, 2014 Jan 15. PMID 23962955
  4. Decreased EGR3 expression is related to poor prognosis in patients with gastric cancer. Liao F, et al. J Mol Histol, 2013 Aug. PMID 23460371
  5. Early growth response 3 (Egr3) is highly over-expressed in non-relapsing prostate cancer but not in relapsing prostate cancer. Pio R, et al. PLoS One, 2013. PMID 23342084, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of Early Growth Response 3 in Skin Cancers.
    Title: Expression of Early Growth Response 3 in Skin Cancers.
  2. EGR3 and estrone are involved in the tamoxifen resistance and progression of breast cancer.
    Title: EGR3 and estrone are involved in the tamoxifen resistance and progression of breast cancer.
  3. Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.
    Title: Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.
  4. The EGR3 regulome of infant KMT2A-r acute lymphoblastic leukemia identifies differential expression of B-lineage genes predictive for outcome.
    Title: The EGR3 regulome of infant KMT2A-r acute lymphoblastic leukemia identifies differential expression of B-lineage genes predictive for outcome.
  5. XIST promotes apoptosis and the inflammatory response in CSE-stimulated cells via the miR-200c-3p/EGR3 axis.
    Title: XIST promotes apoptosis and the inflammatory response in CSE-stimulated cells via the miR-200c-3p/EGR3 axis.
  6. Schizophrenia risk candidate EGR3 is a novel transcriptional regulator of RELN and regulates neurite outgrowth via the Reelin signal pathway in vitro.
    Title: Schizophrenia risk candidate EGR3 is a novel transcriptional regulator of RELN and regulates neurite outgrowth via the Reelin signal pathway in vitro.
  7. HELQ and EGR3 expression correlate with IGHV mutation status and prognosis in chronic lymphocytic leukemia.
    Title: HELQ and EGR3 expression correlate with IGHV mutation status and prognosis in chronic lymphocytic leukemia.
  8. Expression and prognostic value of the transcription factors EGR1 and EGR3 in gliomas.
    Title: Expression and prognostic value of the transcription factors EGR1 and EGR3 in gliomas.
  9. Silencing of miRNA-210 inhibits the progression of liver cancer and Hepatitis B virus-associated liver cancer via up-regulating EGR3.
    Title: Silencing of microRNA-210 inhibits the progression of liver cancer and hepatitis B virus-associated liver cancer via targeting EGR3.
  10. Study demonstrated that EGR3 expression was enhanced in prostate cancer (PC) tissues. EGR3 was proposed as a possible target of miR335, and was negatively regulated by miR335. Silencing EGR3 suppressed the viability and angiogenesis of PC cell line.
    Title: Overexpressing miR‑335 inhibits DU145 cell proliferation by targeting early growth response 3 in prostate cancer.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of early growth response 3 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed
tat HIV-1 Tat (through amino acids 30-40) binds to Egr-3 and synergizes with this protein to super induce the FasL promoter PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC138484

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to fibroblast growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to vascular endothelial growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in circadian rhythm TAS
Traceable Author Statement
more info
 PubMed 
involved_in endothelial cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle organ development TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuromuscular synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in peripheral nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of gamma-delta T cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
early growth response protein 3
Names
zinc finger protein pilot

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199880.2 → NP_001186809.1  early growth response protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001186809.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) initiates from a distinct promoter and has a different 5' end, compared to variant (1). It encodes an isoform (2) with a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC105046, AK294968, AK295134, N66802, S40832, X63741
    Consensus CDS
    CCDS56528.1
    UniProtKB/Swiss-Prot
    Q06889
    UniProtKB/TrEMBL
    B4DH80
    Related
    ENSP00000430310.1, ENST00000522910.1
    Conserved Domains (2) summary
    COG5048
    Location:265 → 338
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:239 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001199881.2 → NP_001186810.1  early growth response protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001186810.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) initiates from a distinct promoter and has a different 5' end, compared to variant (1). It encodes an isoform (3) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC105046, AK294968, DC333411, N66802, S40832, X63741
    UniProtKB/TrEMBL
    B4DH80
    Conserved Domains (4) summary
    COG5048
    Location:249 → 305
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223 → 245
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:221 → 245
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:265 → 290
    zf-H2C2_2; Zinc-finger double domain

  3. NM_004430.3 → NP_004421.2  early growth response protein 3 isoform 1

    See identical proteins and their annotated locations for NP_004421.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC105046, N66802, S40832, X63741
    Consensus CDS
    CCDS6033.1
    UniProtKB/Swiss-Prot
    A8K8U9, B4DHJ5, E7EW38, Q06889, Q2M3W2
    Related
    ENSP00000318057.2, ENST00000317216.3
    Conserved Domains (3) summary
    sd00017
    Location:277 → 299
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:275 → 299
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:319 → 344
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    22687659..22693480 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544429.3 → XP_011542731.2  early growth response protein 3 isoform X2

  2. XM_005273425.4 → XP_005273482.1  early growth response protein 3 isoform X1

    See identical proteins and their annotated locations for XP_005273482.1

    Conserved Domains (5) summary
    COG5048
    Location:358 → 431
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:332 → 354
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:330 → 354
    zf-C2H2; Zinc finger, C2H2 type
    pfam11928
    Location:142 → 202
    DUF3446; Domain of unknown function (DUF3446)
    pfam13465
    Location:374 → 399
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    22961911..22967732 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359947.1 → XP_054215922.1  early growth response protein 3 isoform X3

  2. XM_054359946.1 → XP_054215921.1  early growth response protein 3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06889.1 GenPept UniProtKB/Swiss-Prot:Q06889

Gene LinkOut

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