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ANTXRL ANTXR like [ Homo sapiens (human) ]

Gene ID: 195977, updated on 5-Mar-2024

Summary

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Official Symbol
ANTXRLprovided by HGNC
Official Full Name
ANTXR likeprovided by HGNC
Primary source
HGNC:HGNC:27277
See related
Ensembl:ENSG00000274209 AllianceGenome:HGNC:27277
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in toxin transport. Predicted to be integral component of membrane. Predicted to be active in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 3.2) See more
Orthologs
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Genomic context

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Location:
10q11.22
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (46286092..46330129)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (47171217..47216165)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (47658233..47701365)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ANTXR like pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47599617-47600271 Neighboring gene adenosylhomocysteinase pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3325 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47620679-47621178 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47622387-47622887 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47622963-47623464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47637588-47638253 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47643189-47644058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47644059-47644928 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2351 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2352 Neighboring gene uncharacterized LOC105378577 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47669003-47669503 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47671191-47671769 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47676205-47676704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47679859-47680464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47680465-47681068 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47685074-47685574 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 14, pseudogene Neighboring gene protein FAM25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Tumor stroma-targeted antibody-drug conjugate triggers localized anticancer drug release. Szot C, et al. J Clin Invest, 2018 Jul 2. PMID 29863500, Free PMC Article
  2. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
anthrax toxin receptor-like
Names
anthrax toxin receptor like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278688.3 → NP_001265617.1  anthrax toxin receptor-like isoform 1 precursor

    See identical proteins and their annotated locations for NP_001265617.1

    Status: VALIDATED

    Source sequence(s)
    AC244230, AL450388
    Consensus CDS
    CCDS60524.1
    UniProtKB/Swiss-Prot
    A6NF34, H3BPS2
    UniProtKB/TrEMBL
    A0A2U7XUX1
    Related
    ENSP00000480615.1, ENST00000620264.5
    Conserved Domains (3) summary
    pfam05587
    Location:249 → 348
    Anth_Ig; Anthrax receptor extracellular domain
    pfam15800
    Location:490 → 612
    CiPC; Clock interacting protein circadian
    cl00057
    Location:71 → 254
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  2. NM_001354208.2 → NP_001341137.1  anthrax toxin receptor-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC244230, AL450388

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    46286092..46330129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424705.1 → XP_047280661.1  anthrax toxin receptor-like isoform X5

  2. XM_011539430.3 → XP_011537732.1  anthrax toxin receptor-like isoform X1

    Conserved Domains (2) summary
    pfam05587
    Location:256 → 348
    Anth_Ig; Anthrax receptor extracellular domain
    cl00057
    Location:71 → 254
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  3. XM_006717684.4 → XP_006717747.1  anthrax toxin receptor-like isoform X2

    Conserved Domains (2) summary
    pfam05587
    Location:256 → 349
    Anth_Ig; Anthrax receptor extracellular domain
    cl00057
    Location:71 → 254
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  4. XM_011539442.1 → XP_011537744.1  anthrax toxin receptor-like isoform X9

    Conserved Domains (2) summary
    pfam05587
    Location:256 → 350
    Anth_Ig; Anthrax receptor extracellular domain
    cl00057
    Location:71 → 254
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  5. XM_011539441.1 → XP_011537743.1  anthrax toxin receptor-like isoform X8

    Conserved Domains (2) summary
    pfam05587
    Location:256 → 349
    Anth_Ig; Anthrax receptor extracellular domain
    cl00057
    Location:71 → 254
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  6. XM_047424706.1 → XP_047280662.1  anthrax toxin receptor-like isoform X5

  7. XM_047424704.1 → XP_047280660.1  anthrax toxin receptor-like isoform X5

  8. XM_011539437.3 → XP_011537739.1  anthrax toxin receptor-like isoform X7

    See identical proteins and their annotated locations for XP_011537739.1

    Conserved Domains (2) summary
    pfam05587
    Location:105 → 197
    Anth_Ig; Anthrax receptor extracellular domain
    cl00057
    Location:1 → 103
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  9. XM_047424707.1 → XP_047280663.1  anthrax toxin receptor-like isoform X6

  10. XM_011539433.3 → XP_011537735.1  anthrax toxin receptor-like isoform X6

    See identical proteins and their annotated locations for XP_011537735.1

    Conserved Domains (2) summary
    pfam05587
    Location:145 → 237
    Anth_Ig; Anthrax receptor extracellular domain
    cl00057
    Location:1 → 143
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  11. XM_011539438.3 → XP_011537740.1  anthrax toxin receptor-like isoform X7

    See identical proteins and their annotated locations for XP_011537740.1

    Conserved Domains (2) summary
    pfam05587
    Location:105 → 197
    Anth_Ig; Anthrax receptor extracellular domain
    cl00057
    Location:1 → 103
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  12. XM_017015818.2 → XP_016871307.1  anthrax toxin receptor-like isoform X4

  13. XM_011539434.3 → XP_011537736.1  anthrax toxin receptor-like isoform X6

    See identical proteins and their annotated locations for XP_011537736.1

    Conserved Domains (2) summary
    pfam05587
    Location:145 → 237
    Anth_Ig; Anthrax receptor extracellular domain
    cl00057
    Location:1 → 143
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  14. XM_047424708.1 → XP_047280664.1  anthrax toxin receptor-like isoform X7

  15. XM_017015819.2 → XP_016871308.1  anthrax toxin receptor-like isoform X7

    Conserved Domains (2) summary
    pfam05587
    Location:105 → 197
    Anth_Ig; Anthrax receptor extracellular domain
    cl00057
    Location:1 → 103
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  16. XM_011539431.3 → XP_011537733.1  anthrax toxin receptor-like isoform X3

    Conserved Domains (2) summary
    pfam05587
    Location:187 → 279
    Anth_Ig; Anthrax receptor extracellular domain
    cl00057
    Location:37 → 185
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  17. XM_011539443.2 → XP_011537745.1  anthrax toxin receptor-like isoform X10

RNA

  1. XR_945612.2 RNA Sequence

  2. XR_945614.2 RNA Sequence

  3. XR_945615.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    47171217..47216165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364970.1 → XP_054220945.1  anthrax toxin receptor-like isoform X5

  2. XM_054364966.1 → XP_054220941.1  anthrax toxin receptor-like isoform X1

  3. XM_054364967.1 → XP_054220942.1  anthrax toxin receptor-like isoform X2

  4. XM_054364981.1 → XP_054220956.1  anthrax toxin receptor-like isoform X9

  5. XM_054364980.1 → XP_054220955.1  anthrax toxin receptor-like isoform X8

  6. XM_054364972.1 → XP_054220947.1  anthrax toxin receptor-like isoform X5

  7. XM_054364971.1 → XP_054220946.1  anthrax toxin receptor-like isoform X5

  8. XM_054364976.1 → XP_054220951.1  anthrax toxin receptor-like isoform X7

  9. XM_054364973.1 → XP_054220948.1  anthrax toxin receptor-like isoform X6

  10. XM_054364974.1 → XP_054220949.1  anthrax toxin receptor-like isoform X6

  11. XM_054364977.1 → XP_054220952.1  anthrax toxin receptor-like isoform X7

  12. XM_054364969.1 → XP_054220944.1  anthrax toxin receptor-like isoform X4

  13. XM_054364975.1 → XP_054220950.1  anthrax toxin receptor-like isoform X6

  14. XM_054364979.1 → XP_054220954.1  anthrax toxin receptor-like isoform X7

  15. XM_054364978.1 → XP_054220953.1  anthrax toxin receptor-like isoform X7

  16. XM_054364968.1 → XP_054220943.1  anthrax toxin receptor-like isoform X3

  17. XM_054364982.1 → XP_054220957.1  anthrax toxin receptor-like isoform X10

RNA

  1. XR_008488171.1 RNA Sequence

  2. XR_008488172.1 RNA Sequence

  3. XR_008488173.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_003601.1: Suppressed sequence

    Description
    NR_003601.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NF34.3 GenPept UniProtKB/Swiss-Prot:A6NF34

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