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Pom121l2 POM121 transmembrane nucleoporin like 2 [ Mus musculus (house mouse) ]

Gene ID: 195236, updated on 5-Mar-2024

Summary

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Official Symbol
Pom121l2provided by MGI
Official Full Name
POM121 transmembrane nucleoporin like 2provided by MGI
Primary source
MGI:MGI:2684870
See related
Ensembl:ENSMUSG00000016982 AllianceGenome:MGI:2684870
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm24
Summary
Predicted to enable nuclear localization sequence binding activity. Predicted to be a structural constituent of nuclear pore. Predicted to be involved in RNA export from nucleus and protein import into nucleus. Predicted to be part of nuclear pore. Orthologous to human POM121L2 (POM121 transmembrane nucleoporin like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 35.1) See more
Orthologs
human all
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Genomic context

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See Pom121l2 in Genome Data Viewer
Location:
13 A3.1; 13 8.11 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (22165351..22172904)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (21981181..21988734)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA lysine 22 (anticodon TTT) Neighboring gene STARR-positive B cell enhancer ABC_E7210 Neighboring gene nuclear encoded tRNA methionine 8 (anticodon CAT) Neighboring gene nuclear encoded tRNA serine 8 (anticodon GCT) Neighboring gene nuclear encoded tRNA glutamine 1 (anticodon CTG)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
POM121-like protein 2
Names
POM121 membrane glycoprotein-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162928.1 → NP_001156400.1  POM121-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001156400.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL589879, AL590614, AL606968
    Consensus CDS
    CCDS49217.1
    UniProtKB/Swiss-Prot
    Q5SW25
    Related
    ENSMUSP00000017126.5, ENSMUST00000017126.6
    Conserved Domains (2) summary
    PHA03255
    Location:627 → 756
    PHA03255; BDLF3; Provisional
    pfam15229
    Location:164 → 341
    POM121; POM121 family

  2. NM_001162929.1 → NP_001156401.1  POM121-like protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001156401.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) has a substantially shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK133022
    Consensus CDS
    CCDS49216.1
    UniProtKB/TrEMBL
    Q3V0N0
    Related
    ENSMUSP00000113688.2, ENSMUST00000117882.2
    Conserved Domains (1) summary
    pfam15229
    Location:164 → 341
    POM121; POM121 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    22165351..22172904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SW25.1 GenPept UniProtKB/Swiss-Prot:Q5SW25

Gene LinkOut

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