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Sun3 Sad1 and UNC84 domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 194974, updated on 18-Sep-2024

Summary

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Official Symbol
Sun3provided by MGI
Official Full Name
Sad1 and UNC84 domain containing 3provided by MGI
Primary source
MGI:MGI:3041199
See related
Ensembl:ENSMUSG00000040985 AllianceGenome:MGI:3041199
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sunc1
Summary
Predicted to enable protein-membrane adaptor activity. Predicted to be involved in nuclear envelope organization. Part of meiotic nuclear membrane microtubule tethering complex. Orthologous to human SUN3 (Sad1 and UNC84 domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 19.5) and kidney adult (RPKM 1.6) See more
Orthologs
human all
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Genomic context

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See Sun3 in Genome Data Viewer
Location:
11 A1; 11 5.77 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (8962704..8998991, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (9016043..9048991, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene polycystic kidney disease 1 like 1 Neighboring gene STARR-seq mESC enhancer starr_28552 Neighboring gene predicted gene, 57803 Neighboring gene HUS1 checkpoint clamp component Neighboring gene predicted gene 11992 Neighboring gene STARR-seq mESC enhancer starr_28553 Neighboring gene STARR-seq mESC enhancer starr_28555 Neighboring gene uridine phosphorylase 1 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide C pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The testis-specific LINC component SUN3 is essential for sperm head shaping during mouse spermiogenesis. Gao Q, et al. J Biol Chem, 2020 May 8. PMID 32156700, Free PMC Article
  2. Mammalian sperm head formation involves different polarization of two novel LINC complexes. Göb E, et al. PLoS One, 2010 Aug 10. PMID 20711465, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The testis-specific LINC component SUN3 is essential for sperm head shaping during mouse spermiogenesis.
    Title: The testis-specific LINC component SUN3 is essential for sperm head shaping during mouse spermiogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC130135, D630047F21Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-membrane adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of meiotic nuclear membrane microtubule tethering complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of meiotic nuclear membrane microtubule tethering complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SUN domain-containing protein 3
Names
Sad1 and UNC84 domain containing 1
sad1/unc-84 domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290519.1 → NP_001277448.1  SUN domain-containing protein 3 isoform a

    See identical proteins and their annotated locations for NP_001277448.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AK132922
    Consensus CDS
    CCDS70140.1
    UniProtKB/Swiss-Prot
    Q5SS91, Q8BHY0
    UniProtKB/TrEMBL
    E9LV81
    Related
    ENSMUSP00000045199.6, ENSMUST00000043377.6
    Conserved Domains (1) summary
    pfam07738
    Location:182 → 316
    Sad1_UNC; Sad1 / UNC-like C-terminal

  2. NM_001290520.1 → NP_001277449.1  SUN domain-containing protein 3 isoform b

    See identical proteins and their annotated locations for NP_001277449.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5'-terminal exon, lacks part of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK052771
    Consensus CDS
    CCDS24430.1
    UniProtKB/Swiss-Prot
    Q5SS91
    Conserved Domains (1) summary
    pfam07738
    Location:122 → 256
    Sad1_UNC; Sad1 / UNC-like C-terminal

  3. NM_177576.3 → NP_808244.1  SUN domain-containing protein 3 isoform b

    See identical proteins and their annotated locations for NP_808244.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5'-terminal exon, lacks part of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK052771
    Consensus CDS
    CCDS24430.1
    UniProtKB/Swiss-Prot
    Q5SS91
    Related
    ENSMUSP00000099973.2, ENSMUST00000102909.8
    Conserved Domains (1) summary
    pfam07738
    Location:122 → 256
    Sad1_UNC; Sad1 / UNC-like C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    8962704..8998991 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514597.5 → XP_006514660.1  SUN domain-containing protein 3 isoform X2

    Conserved Domains (1) summary
    pfam07738
    Location:180 → 314
    Sad1_UNC; Sad1 / UNC-like C-terminal

  2. XM_006514595.5 → XP_006514658.1  SUN domain-containing protein 3 isoform X1

    Conserved Domains (1) summary
    pfam07738
    Location:206 → 340
    Sad1_UNC; Sad1 / UNC-like C-terminal

  3. XM_030245703.2 → XP_030101563.1  SUN domain-containing protein 3 isoform X4

    Conserved Domains (1) summary
    pfam07738
    Location:122 → 256
    Sad1_UNC; Sad1 / UNC-like C-terminal

  4. XM_036156457.1 → XP_036012350.1  SUN domain-containing protein 3 isoform X4

    Conserved Domains (1) summary
    pfam07738
    Location:122 → 256
    Sad1_UNC; Sad1 / UNC-like C-terminal

  5. XM_006514598.4 → XP_006514661.1  SUN domain-containing protein 3 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SS91.1 GenPept UniProtKB/Swiss-Prot:Q5SS91

Gene LinkOut

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