U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rhox4e reproductive homeobox 4E [ Mus musculus (house mouse) ]

Gene ID: 194856, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Rhox4eprovided by MGI
Official Full Name
reproductive homeobox 4Eprovided by MGI
Primary source
MGI:MGI:3613390
See related
Ensembl:ENSMUSG00000071770 AllianceGenome:MGI:3613390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rhox4; Rhox4d; Rhox4.5
Summary
Predicted to enable identical protein binding activity and sequence-specific double-stranded DNA binding activity. Orthologous to human RHOXF2 (Rhox homeobox family member 2) and RHOXF2B (Rhox homeobox family member 2B). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: This gene was previously named "Rhox4d" by MacLean, et. al. Genesis (2006) 44:122 (PubMed ID: 16496311) and "Rhox4.5" by Morris, et. al. Mamm. Genome (2006) 17:178 (PubMed ID: 16465597). Its official nomenclature is now Rhox4e. [07 Jan 2013]
Expression
Biased expression in placenta adult (RPKM 4.1), thymus adult (RPKM 0.3) and 1 other tissue See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
X A3.3; X 21.86 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (36739065..36743935)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (37557412..37562283)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene reproductive homeobox 2E Neighboring gene reproductive homeobox 3E Neighboring gene predicted gene, 38640 Neighboring gene reproductive homeobox 2F Neighboring gene reproductive homeobox 3F

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Rhox homeobox gene cluster: recent duplication of three family members. MacLean JA 2nd, et al. Genesis, 2006 Mar. PMID 16496311
  2. Identification of a tandem duplicated array in the Rhox alpha locus on mouse chromosome X. Morris L, et al. Mamm Genome, 2006 Feb. PMID 16465597
  3. Rhox: a new homeobox gene cluster. Maclean JA 2nd, et al. Cell, 2005 Feb 11. PMID 15707895
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

Go to the top of the page Help
Preferred Names
reproductive homeobox 4E

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201236.3 → NP_957688.2  reproductive homeobox 4E

    See identical proteins and their annotated locations for NP_957688.2

    Status: VALIDATED

    Source sequence(s)
    AJ972669
    Consensus CDS
    CCDS30078.1
    UniProtKB/TrEMBL
    B7ZWM1, Q504P9
    Related
    ENSMUSP00000086475.5, ENSMUST00000089075.6
    Conserved Domains (2) summary
    cd00086
    Location:129 → 187
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    cl21455
    Location:41 → 126
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    36739065..36743935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541445.2 → XP_006541508.1  reproductive homeobox 4E isoform X1

    UniProtKB/TrEMBL
    B7ZWM1
    Conserved Domains (1) summary
    cl38985
    Location:41 → 126
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools