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Abhd16a abhydrolase domain containing 16A [ Mus musculus (house mouse) ]

Gene ID: 193742, updated on 2-Nov-2024

Summary

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Official Symbol
Abhd16aprovided by MGI
Official Full Name
abhydrolase domain containing 16Aprovided by MGI
Primary source
MGI:MGI:99476
See related
Ensembl:ENSMUSG00000007036 AllianceGenome:MGI:99476
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bat5; NG26; Bat-5; mBAT5; D17H6S82E
Summary
Enables monoacylglycerol lipase activity and phospholipase activity. Involved in monoacylglycerol catabolic process; phosphatidylserine catabolic process; and prostaglandin catabolic process. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 86. Orthologous to human ABHD16A (abhydrolase domain containing 16A, phospholipase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in cerebellum adult (RPKM 54.1), adrenal adult (RPKM 49.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Abhd16a in Genome Data Viewer
Location:
17 B1; 17 18.59 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35308210..35321963)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35089234..35102987)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 6 family member G6D Neighboring gene STARR-seq mESC enhancer starr_42446 Neighboring gene lymphocyte antigen 6 family member G6E Neighboring gene lymphocyte antigen 6 family member G6F Neighboring gene STARR-positive B cell enhancer ABC_E7527 Neighboring gene lymphocyte antigen 6 family member G5C Neighboring gene lymphocyte antigen 6 family member G5B Neighboring gene casein kinase 2, beta polypeptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mapping the Neuroanatomy of ABHD16A, ABHD12, and Lysophosphatidylserines Provides New Insights into the Pathophysiology of the Human Neurological Disorder PHARC. Singh S, et al. Biochemistry, 2020 Jun 23. PMID 32462874, Free PMC Article
  2. MHC-linked diabetogenic gene of the NOD mouse: molecular mapping of the 3' boundary of the diabetogenic region. Ikegami H, et al. Biochem Biophys Res Commun, 1993 Apr 30. PMID 8097912
  3. Identification of a recombinational breakpoint at the BAT5 locus in three intra-H-2 recombinant inbred mouse strains. Mathew PA, et al. Exp Clin Immunogenet, 1995. PMID 8919359
  4. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay. Kamat SS, et al. Nat Chem Biol, 2015 Feb. PMID 25580854, Free PMC Article
  5. Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A). Savinainen JR, et al. PLoS One, 2014. PMID 25290914, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mapping the Neuroanatomy of ABHD16A, ABHD12, and Lysophosphatidylserines Provides New Insights into the Pathophysiology of the Human Neurological Disorder PHARC.
    Title: Mapping the Neuroanatomy of ABHD16A, ABHD12, and Lysophosphatidylserines Provides New Insights into the Pathophysiology of the Human Neurological Disorder PHARC.
  2. BAT5 is a genuine lipase with preference for long-chain unsaturated monoacylglycerols, and could in this capacity regulate glycerolipid metabolism in vivo as well.
    Title: Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A).
  3. In mouse macrophages, disruption of ABHD12 and ABHD16A respectively increases and decreases both lysophosphatidylserines and lipopolysaccharide-induced cytokine production.
    Title: Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC19234

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables monoacylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoacylglycerol lipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoacylglycerol lipase activity ISO
Inferred from Sequence Orthology
more info
  
enables phospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in monoacylglycerol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoacylglycerol catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoacylglycerol catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylserine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylserine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in prostaglandin catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in prostaglandin catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylserine lipase ABHD16A
Names
HLA-B associated transcript 5
abhydrolase domain-containing protein 16A
alpha/beta hydrolase domain-containing protein 16A
monoacylglycerol lipase ABHD16A
protein ABHD16A
protein BAT5
NP_001397269.1
NP_001397270.1
NP_001397271.1
NP_001397272.1
NP_001397274.1
NP_001397275.1
NP_001397276.1
NP_001404608.1
NP_848707.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410340.1 → NP_001397269.1  phosphatidylserine lipase ABHD16A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087117

  2. NM_001410341.1 → NP_001397270.1  phosphatidylserine lipase ABHD16A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC087117

  3. NM_001410342.1 → NP_001397271.1  phosphatidylserine lipase ABHD16A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087117

  4. NM_001410343.1 → NP_001397272.1  phosphatidylserine lipase ABHD16A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC087117

  5. NM_001410345.1 → NP_001397274.1  phosphatidylserine lipase ABHD16A isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC087117

  6. NM_001410346.1 → NP_001397275.1  phosphatidylserine lipase ABHD16A isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC087117

  7. NM_001410347.1 → NP_001397276.1  phosphatidylserine lipase ABHD16A isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC087117

  8. NM_001417679.1 → NP_001404608.1  phosphatidylserine lipase ABHD16A isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC087117

  9. NM_178592.4 → NP_848707.1  phosphatidylserine lipase ABHD16A isoform 1

    See identical proteins and their annotated locations for NP_848707.1

    Status: VALIDATED

    Source sequence(s)
    AC087117
    Consensus CDS
    CCDS28681.1
    UniProtKB/Swiss-Prot
    Q9Z1Q2
    Related
    ENSMUSP00000007251.8, ENSMUST00000007251.14
    Conserved Domains (1) summary
    pfam00561
    Location:280 → 408
    Abhydrolase_1; alpha/beta hydrolase fold

RNA

  1. NR_177060.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC087117

  2. NR_177061.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC087117
    Related
    ENSMUST00000173846.8

  3. NR_184561.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC087117

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35308210..35321963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004939480.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z1Q2.3 GenPept UniProtKB/Swiss-Prot:Q9Z1Q2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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