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Rnf185 ring finger protein 185 [ Mus musculus (house mouse) ]

Gene ID: 193670, updated on 2-Nov-2024

Summary

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Official Symbol
Rnf185provided by MGI
Official Full Name
ring finger protein 185provided by MGI
Primary source
MGI:MGI:1922078
See related
Ensembl:ENSMUSG00000020448 AllianceGenome:MGI:1922078
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable ubiquitin binding activity; ubiquitin protein ligase activity; and ubiquitin-like protein conjugating enzyme binding activity. Predicted to be involved in several processes, including positive regulation of ERAD pathway; protein ubiquitination; and proteolysis involved in protein catabolic process. Predicted to be located in endoplasmic reticulum. Is expressed in central nervous system; genitourinary system; and olfactory epithelium. Orthologous to human RNF185 (ring finger protein 185). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 16.3), kidney adult (RPKM 15.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rnf185 in Genome Data Viewer
Location:
11 A1; 11 2.4 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3365973..3402956, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3415973..3452956, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12592 Neighboring gene STARR-positive B cell enhancer ABC_E5203 Neighboring gene STARR-positive B cell enhancer ABC_E2345 Neighboring gene STARR-positive B cell enhancer ABC_E3929 Neighboring gene phosphoinositide-3-kinase interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_28349 Neighboring gene LIM domain kinase 2 Neighboring gene STARR-seq mESC enhancer starr_28351 Neighboring gene STARR-positive B cell enhancer ABC_E1818 Neighboring gene predicted gene, 51879 Neighboring gene RIKEN cDNA 8430429K09 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:3352424-3352533 Neighboring gene predicted gene, 53661 Neighboring gene 39S ribosomal protein L30, mitochondrial pseudogene Neighboring gene phospholipase A2, group III Neighboring gene inositol polyphosphate 5-phosphatase J

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RNF185 Control of COL3A1 Expression Limits Prostate Cancer Migration and Metastatic Potential. Van Espen B, et al. Mol Cancer Res, 2024 Jan 2. PMID 37831068, Free PMC Article
  2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  3. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
  4. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNF185 Control of COL3A1 Expression Limits Prostate Cancer Migration and Metastatic Potential.
    Title: RNF185 Control of COL3A1 Expression Limits Prostate Cancer Migration and Metastatic Potential.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC19394, 1700022N24Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-like protein conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like protein conjugating enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-like protein conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to virus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERAD pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type I interferon-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K27-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K27-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF185
Names
RING-type E3 ubiquitin transferase RNF185
NP_001277401.1
NP_001277402.1
NP_663330.2
XP_006514657.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290472.1 → NP_001277401.1  E3 ubiquitin-protein ligase RNF185 isoform 2

    See identical proteins and their annotated locations for NP_001277401.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks part of the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK034108, AK075756, AL713875, AV347010
    Consensus CDS
    CCDS70127.1
    UniProtKB/Swiss-Prot
    Q6ZWS3, Q91YT2
    Related
    ENSMUSP00000076333.6, ENSMUST00000077078.12
    Conserved Domains (1) summary
    cd00162
    Location:38 → 83
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  2. NM_001290473.1 → NP_001277402.1  E3 ubiquitin-protein ligase RNF185 isoform 3

    See identical proteins and their annotated locations for NP_001277402.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK034108, AK075756, AL713875, AV347010
    UniProtKB/Swiss-Prot
    Q91YT2
    Conserved Domains (2) summary
    PLN03208
    Location:29 → 65
    PLN03208; E3 ubiquitin-protein ligase RMA2; Provisional
    cl17238
    Location:8 → 33
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. NM_145355.5 → NP_663330.2  E3 ubiquitin-protein ligase RNF185 isoform 1

    See identical proteins and their annotated locations for NP_663330.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK034108, AK075756, AL713875, AV347010
    Consensus CDS
    CCDS24361.1
    UniProtKB/Swiss-Prot
    Q91YT2
    Related
    ENSMUSP00000067053.3, ENSMUST00000064364.3
    Conserved Domains (1) summary
    cd00162
    Location:74 → 119
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RNA

  1. NR_110959.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two consecutive internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AK034108, AK075756, AL713875, AV347010

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    3365973..3402956 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514594.5 → XP_006514657.1  E3 ubiquitin-protein ligase RNF185 isoform X1

    See identical proteins and their annotated locations for XP_006514657.1

    Conserved Domains (2) summary
    PLN03208
    Location:29 → 65
    PLN03208; E3 ubiquitin-protein ligase RMA2; Provisional
    cl17238
    Location:8 → 33
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91YT2.1 GenPept UniProtKB/Swiss-Prot:Q91YT2

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