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Rad54l RAD54 like (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 19366, updated on 2-Nov-2024

Summary

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Official Symbol
Rad54lprovided by MGI
Official Full Name
RAD54 like (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:894697
See related
Ensembl:ENSMUSG00000028702 AllianceGenome:MGI:894697
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RAD54
Summary
Predicted to enable ATP-dependent DNA/DNA annealing activity and DNA translocase activity. Acts upstream of or within several processes, including determination of adult lifespan; double-strand break repair via homologous recombination; and response to ionizing radiation. Predicted to be located in nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in several structures, including brain ventricular layer; incisor; metencephalon rest of alar plate marginal layer; submandibular gland primordium; and thymus primordium. Used to study sclerocornea. Human ortholog(s) of this gene implicated in breast cancer; disease of cellular proliferation; non-Hodgkin lymphoma; and pancreatic cancer. Orthologous to human RAD54L (RAD54 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 12.3), testis adult (RPKM 10.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rad54l in Genome Data Viewer
Location:
4 D1; 4 53.1 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115951458..115980875, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116094261..116123700, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12854 Neighboring gene STARR-positive B cell enhancer ABC_E4647 Neighboring gene ubiquinol-cytochrome c reductase hinge protein Neighboring gene leucine rich repeat containing 41 Neighboring gene predicted gene, 52704 Neighboring gene RIKEN cDNA 2510003B16 gene Neighboring gene STARR-positive B cell enhancer ABC_E10248 Neighboring gene STARR-seq mESC enhancer starr_11132 Neighboring gene leucine rich adaptor protein 1 Neighboring gene protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination. Essers J, et al. Cell, 1997 Apr 18. PMID 9108475
  2. Gene conversion-like sequence transfers between transgenic antibody V genes are independent of RAD54. D'Avirro N, et al. J Immunol, 2002 Sep 15. PMID 12218123
  3. Homologous and non-homologous recombination differentially affect DNA damage repair in mice. Essers J, et al. EMBO J, 2000 Apr 3. PMID 10747037, Free PMC Article
  4. Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: evidence for functional conservation. Kanaar R, et al. Curr Biol, 1996 Jul 1. PMID 8805304
  5. Role of mammalian Rad54 in telomere length maintenance. Jaco I, et al. Mol Cell Biol, 2003 Aug. PMID 12897131, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our study highlights the importance of the cooperation between Rad54 and Mus81 for mediating DNA DSB repair and restraining chromosome missegregation.
    Title: Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation.
  2. These results reveal a differential interaction of the ATM-mediated DNA damage response and Rad54 paralog-mediated homologous recombination depending on the DNA damaging agent that initiates the response.
    Title: Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair.
  3. Mus81-Eme1- and Rad54-mediated homologous recombination are involved in the same DNA replication-dependent interstrand crosslinks repair pathway
    Title: The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks.
  4. Rad54 is not required for either transgene isotype switching or transgene hypermutation.
    Title: Gene conversion-like sequence transfers between transgenic antibody V genes are independent of RAD54.
  5. Rad54-mediated homologous recombination is not essential for somatic hypermutation. In addition, the finding that the ablation of RAD51 paralogues causes an increase in SHM argues against a direct involvement of HR in promoting SHM.
    Title: Somatic hypermutation does not require Rad54 and Rad54B-mediated homologous recombination.
  6. Rad54 cooperates with DNA Ligase IV to support cellular proliferation, dna repair, and prevent chromosome and single chromatid aberrations
    Title: Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability.
  7. Rad54 has a role in telomere length maintenance
    Title: Role of mammalian Rad54 in telomere length maintenance.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (2) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent DNA/DNA annealing activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP-dependent DNA/DNA annealing activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA translocase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromosome organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within double-strand break repair IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within double-strand break repair via homologous recombination IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via synthesis-dependent strand annealing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to ionizing radiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA repair and recombination protein RAD54-like
Names
RAD54 homolog
mHR54
mRAD54
NP_001116430.1
NP_001116431.1
NP_001411773.1
NP_001411774.1
NP_001411775.1
NP_001411776.1
NP_001411777.1
NP_033041.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122958.2 → NP_001116430.1  DNA repair and recombination protein RAD54-like isoform 1

    See identical proteins and their annotated locations for NP_001116430.1

    Status: VALIDATED

    Source sequence(s)
    AL611947, AL627105
    Consensus CDS
    CCDS18504.1
    UniProtKB/Swiss-Prot
    P70270, Q8BSR5, Q8C2C4, Q8K3D4
    Related
    ENSMUSP00000099766.4, ENSMUST00000102705.10
    Conserved Domains (3) summary
    COG0553
    Location:107 → 668
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18067
    Location:153 → 395
    DEXHc_RAD54A; DEXH-box helicase domain of RAD54A
    pfam08658
    Location:76 → 123
    Rad54_N; Rad54 N terminal

  2. NM_001122959.2 → NP_001116431.1  DNA repair and recombination protein RAD54-like isoform 1

    See identical proteins and their annotated locations for NP_001116431.1

    Status: VALIDATED

    Source sequence(s)
    AL611947, AL627105
    Consensus CDS
    CCDS18504.1
    UniProtKB/Swiss-Prot
    P70270, Q8BSR5, Q8C2C4, Q8K3D4
    Conserved Domains (3) summary
    COG0553
    Location:107 → 668
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18067
    Location:153 → 395
    DEXHc_RAD54A; DEXH-box helicase domain of RAD54A
    pfam08658
    Location:76 → 123
    Rad54_N; Rad54 N terminal

  3. NM_001424844.1 → NP_001411773.1  DNA repair and recombination protein RAD54-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL611947, AL627105
    UniProtKB/Swiss-Prot
    P70270, Q8BSR5, Q8C2C4, Q8K3D4

  4. NM_001424845.1 → NP_001411774.1  DNA repair and recombination protein RAD54-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL611947, AL627105
    UniProtKB/Swiss-Prot
    P70270, Q8BSR5, Q8C2C4, Q8K3D4

  5. NM_001424846.1 → NP_001411775.1  DNA repair and recombination protein RAD54-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL611947, AL627105

  6. NM_001424847.1 → NP_001411776.1  DNA repair and recombination protein RAD54-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL611947, AL627105

  7. NM_001424848.1 → NP_001411777.1  DNA repair and recombination protein RAD54-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL611947, AL627105

  8. NM_009015.4 → NP_033041.3  DNA repair and recombination protein RAD54-like isoform 1

    See identical proteins and their annotated locations for NP_033041.3

    Status: VALIDATED

    Source sequence(s)
    AL611947, AL627105
    Consensus CDS
    CCDS18504.1
    UniProtKB/Swiss-Prot
    P70270, Q8BSR5, Q8C2C4, Q8K3D4
    Related
    ENSMUSP00000099765.4, ENSMUST00000102704.4
    Conserved Domains (3) summary
    COG0553
    Location:107 → 668
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18067
    Location:153 → 395
    DEXHc_RAD54A; DEXH-box helicase domain of RAD54A
    pfam08658
    Location:76 → 123
    Rad54_N; Rad54 N terminal

RNA

  1. NR_188962.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL611947, AL627105

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    115951458..115980875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70270.2 GenPept UniProtKB/Swiss-Prot:P70270

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