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EEF1D eukaryotic translation elongation factor 1 delta [ Homo sapiens (human) ]

Gene ID: 1936, updated on 7-Apr-2024

Summary

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Official Symbol
EEF1Dprovided by HGNC
Official Full Name
eukaryotic translation elongation factor 1 deltaprovided by HGNC
Primary source
HGNC:HGNC:3211
See related
Ensembl:ENSG00000104529 MIM:130592; AllianceGenome:HGNC:3211
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EF1D; EF-1D; FP1047
Summary
This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, Aug 2010]
Expression
Ubiquitous expression in ovary (RPKM 42.9), spleen (RPKM 28.8) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
8q24.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (143579728..143597415, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (144729124..144746827, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144661898..144679585, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene maestro heat like repeat family member 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144653451-144654300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144659908-144660815 Neighboring gene nicotinate phosphoribosyltransferase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144660816-144661724 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144671257-144671758 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144671759-144672258 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144678233-144678832 Neighboring gene tigger transposable element derived 5 Neighboring gene pyrroline-5-carboxylate reductase 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144692853-144693352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144699896-144700500 Neighboring gene GDP-L-fucose synthase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Biallelic loss of EEF1D function links heat shock response pathway to autosomal recessive intellectual disability. Ugur Iseri SA, et al. J Hum Genet, 2019 May. PMID 30787422
  2. EEF1D overexpression promotes osteosarcoma cell proliferation by facilitating Akt-mTOR and Akt-bad signaling. Cheng DD, et al. J Exp Clin Cancer Res, 2018 Mar 6. PMID 29510727, Free PMC Article
  3. EEF1D modulates proliferation and epithelial-mesenchymal transition in oral squamous cell carcinoma. Flores IL, et al. Clin Sci (Lond), 2016 May 1. PMID 26823560
  4. Alternative expression and sequence of human elongation factor-1 delta during malignant transformation of human bronchial epithelial cells induced by cadmium chloride. Lei YX, et al. Biomed Environ Sci, 2010 Apr. PMID 20514991
  5. BMP-6 promotes E-cadherin expression through repressing deltaEF1 in breast cancer cells. Yang S, et al. BMC Cancer, 2007 Nov 13. PMID 17997862, Free PMC Article

See all (212) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Autoantibodies against eukaryotic translation elongation factor 1 delta in two patients with autoimmune cerebellar ataxia.
    Title: Autoantibodies against eukaryotic translation elongation factor 1 delta in two patients with autoimmune cerebellar ataxia.
  2. EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3K/Akt Pathway.
    Title: EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3K/Akt Pathway.
  3. Eukaryotic Translation Elongation Factor 1 Delta Inhibits the Nuclear Import of the Nucleoprotein and PA-PB1 Heterodimer of Influenza A Virus.
    Title: Eukaryotic Translation Elongation Factor 1 Delta Inhibits the Nuclear Import of the Nucleoprotein and PA-PB1 Heterodimer of Influenza A Virus.
  4. EEF1D is upregulated in osteosarcoma and plays a tumor promoting role by facilitating Akt-mTOR and Akt-Bad signaling pathways. Accordingly, EEF1D is a potential target for cancer therapy.
    Title: EEF1D overexpression promotes osteosarcoma cell proliferation by facilitating Akt-mTOR and Akt-bad signaling.
  5. the loss of function variants exclusively targeting the long EEF1D isoform may explicate the ARID phenotype through the heat shock response pathway, rather than interfering with the canonical translational elongation.
    Title: Biallelic loss of EEF1D function links heat shock response pathway to autosomal recessive intellectual disability.
  6. eukaryotic translation elongation factor 1delta knockdown in oral squamous cell carcinoma reduced cell proliferation and induced EMT (epithelial-mesenchymal transition) phenotypes
    Title: EEF1D modulates proliferation and epithelial-mesenchymal transition in oral squamous cell carcinoma.
  7. our results demonstrate that EEF1D is a bona fide physiological CK2 substrate for CK2 phosphorylation
    Title: Unbiased functional proteomics strategy for protein kinase inhibitor validation and identification of bona fide protein kinase substrates: application to identification of EEF1D as a substrate for CK2.
  8. Taken together, our data suggest EFF1D functions as a novel negative regulator of SIAH-1
    Title: Eukaryotic translation elongation factor 1 delta inhibits the ubiquitin ligase activity of SIAH-1.
  9. overexpression is positively correlated with malignant transformation of 16HBE cells induced by CdC12, but is not correlated with DNA mutations
    Title: Alternative expression and sequence of human elongation factor-1 delta during malignant transformation of human bronchial epithelial cells induced by cadmium chloride.
  10. Repression of deltaEF1 plays a key role in mediating BMP-6-induced transcriptional activation of E-cadherin in breast cancer cells.
    Title: BMP-6 promotes E-cadherin expression through repressing deltaEF1 in breast cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 delta (EEF1D), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 delta (EEF1D), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 delta (EEF1D), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
nef Yeast two hybrid assay identifies the HIV-1 Nef-interacting protein translational elongation factor 1 PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 delta (EEF1D), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Tat tat The second exon of HIV-1 Tat (amino acids 73-86) binds to EF-1delta (amino acids 144-280), thereby dramatically reducing the efficiency of the translation of cellular, but not viral, mRNA PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20897

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables cadherin binding HDA PubMed 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation factor activity, RNA binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to ionizing radiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
colocalizes_with endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic translation elongation factor 1 complex IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
elongation factor 1-delta
Names
EF-1-delta
antigen NY-CO-4
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130053.5 → NP_001123525.3  elongation factor 1-delta isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (1, also known as L).
    Source sequence(s)
    AC067930
    Consensus CDS
    CCDS6404.1
    UniProtKB/TrEMBL
    B2RAR6
    Related
    ENSP00000484536.2, ENST00000618139.4
    Conserved Domains (2) summary
    pfam10587
    Location:525 → 552
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
    pfam00736
    Location:564 → 647
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  2. NM_001130055.4 → NP_001123527.1  elongation factor 1-delta isoform 2

    See identical proteins and their annotated locations for NP_001123527.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5, 6, and 9 encode the same isoform (2).
    Source sequence(s)
    AK225040, BI667117, BQ686171, DA948687
    Consensus CDS
    CCDS6405.1
    UniProtKB/Swiss-Prot
    B4DDU4, D3DWK3, E9PBQ9, P29692, Q4VBZ6, Q969J1, Q96I38
    UniProtKB/TrEMBL
    E9PK01
    Related
    ENSP00000388261.2, ENST00000419152.7
    Conserved Domains (2) summary
    pfam00736
    Location:198 → 281
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:159 → 186
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

  3. NM_001130056.5 → NP_001123528.1  elongation factor 1-delta isoform 4

    See identical proteins and their annotated locations for NP_001123528.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has multiple differences compared to variant 1. The encoded isoform (4) is shorter than isoform 1. Both variants 7, 10, and 11 encode the same isoform (4).
    Source sequence(s)
    AK225040, BC094806, BI667117
    Consensus CDS
    CCDS47930.1
    UniProtKB/TrEMBL
    E9PQZ1
    Related
    ENSP00000431763.1, ENST00000528610.5
    Conserved Domains (2) summary
    pfam00736
    Location:174 → 257
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:135 → 162
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

  4. NM_001130057.4 → NP_001123529.1  elongation factor 1-delta isoform 2

    See identical proteins and their annotated locations for NP_001123529.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5, 6, and 9 encode the same isoform (2).
    Source sequence(s)
    AC067930, AK225040, BG748894, BQ064320, CF128478
    Consensus CDS
    CCDS6405.1
    UniProtKB/Swiss-Prot
    B4DDU4, D3DWK3, E9PBQ9, P29692, Q4VBZ6, Q969J1, Q96I38
    UniProtKB/TrEMBL
    E9PK01
    Related
    ENSP00000317399.6, ENST00000317198.10
    Conserved Domains (2) summary
    pfam00736
    Location:198 → 281
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:159 → 186
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

  5. NM_001195203.4 → NP_001182132.1  elongation factor 1-delta isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. This variant also lacks an additional in-frame exon and uses an alternate in-frame splice site in the CDS. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AK225040, AK293339, BI667117
    Consensus CDS
    CCDS56559.1
    UniProtKB/TrEMBL
    E9PQZ1
    Related
    ENSP00000436507.1, ENST00000526838.5
    Conserved Domains (2) summary
    pfam00736
    Location:179 → 262
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:140 → 167
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

  6. NM_001289950.4 → NP_001276879.1  elongation factor 1-delta isoform 2

    See identical proteins and their annotated locations for NP_001276879.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, lacks a portion of the 5' coding region, and intiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5, 6, and 9 encode the same isoform (2).
    Source sequence(s)
    AC067930
    Consensus CDS
    CCDS6405.1
    UniProtKB/Swiss-Prot
    B4DDU4, D3DWK3, E9PBQ9, P29692, Q4VBZ6, Q969J1, Q96I38
    UniProtKB/TrEMBL
    E9PK01
    Related
    ENSP00000434872.1, ENST00000529272.5
    Conserved Domains (2) summary
    pfam00736
    Location:198 → 281
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:159 → 186
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

  7. NM_001317743.4 → NP_001304672.1  elongation factor 1-delta isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) has multiple differences compared to variant 1. The encoded isoform (4) is shorter than isoform 1. Both variants 7, 10, and 11 encode the same isoform (4).
    Source sequence(s)
    AK225040, BG482145, BI667117
    Consensus CDS
    CCDS47930.1
    UniProtKB/TrEMBL
    E9PQZ1
    Related
    ENSP00000431460.2, ENST00000534377.6
    Conserved Domains (2) summary
    pfam00736
    Location:174 → 257
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:135 → 162
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

  8. NM_001330646.3 → NP_001317575.1  elongation factor 1-delta isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC067930
    Consensus CDS
    CCDS47930.1
    UniProtKB/TrEMBL
    E9PQZ1

  9. NM_001960.7 → NP_001951.2  elongation factor 1-delta isoform 2

    See identical proteins and their annotated locations for NP_001951.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5, 6, and 9 encode the same isoform (2).
    Source sequence(s)
    AK225040, BC012819, BI667117
    Consensus CDS
    CCDS6405.1
    UniProtKB/Swiss-Prot
    B4DDU4, D3DWK3, E9PBQ9, P29692, Q4VBZ6, Q969J1, Q96I38
    UniProtKB/TrEMBL
    E9PK01
    Related
    ENSP00000378551.3, ENST00000395119.7
    Conserved Domains (2) summary
    pfam00736
    Location:198 → 281
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:159 → 186
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

  10. NM_032378.7 → NP_115754.4  elongation factor 1-delta isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1, also known as L).
    Source sequence(s)
    AC067930
    Consensus CDS
    CCDS6404.1
    UniProtKB/TrEMBL
    B2RAR6
    Related
    ENSP00000391944.2, ENST00000442189.6
    Conserved Domains (2) summary
    pfam10587
    Location:525 → 552
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
    pfam00736
    Location:564 → 647
    EF1_GNE; EF-1 guanine nucleotide exchange domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    143579728..143597415 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421455.1 → XP_047277411.1  elongation factor 1-delta isoform X10

  2. XM_017013171.1 → XP_016868660.1  elongation factor 1-delta isoform X7

    UniProtKB/TrEMBL
    B2RAR6
    Conserved Domains (2) summary
    pfam00736
    Location:563 → 646
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:524 → 551
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

  3. XM_047421450.1 → XP_047277406.1  elongation factor 1-delta isoform X9

  4. XM_005250823.1 → XP_005250880.1  elongation factor 1-delta isoform X6

    See identical proteins and their annotated locations for XP_005250880.1

    UniProtKB/TrEMBL
    B2RAR6
    Related
    ENSP00000434070.1, ENST00000532741.5
    Conserved Domains (2) summary
    pfam10587
    Location:525 → 552
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
    pfam00736
    Location:564 → 647
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  5. XM_047421441.1 → XP_047277397.1  elongation factor 1-delta isoform X6

  6. XM_047421423.1 → XP_047277379.1  elongation factor 1-delta isoform X1

  7. XM_006716525.2 → XP_006716588.1  elongation factor 1-delta isoform X11

    See identical proteins and their annotated locations for XP_006716588.1

    UniProtKB/Swiss-Prot
    B4DDU4, D3DWK3, E9PBQ9, P29692, Q4VBZ6, Q969J1, Q96I38
    UniProtKB/TrEMBL
    E9PK01
    Conserved Domains (2) summary
    pfam00736
    Location:198 → 281
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:159 → 186
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

  8. XM_047421445.1 → XP_047277401.1  elongation factor 1-delta isoform X7

  9. XM_047421451.1 → XP_047277407.1  elongation factor 1-delta isoform X9

  10. XM_047421433.1 → XP_047277389.1  elongation factor 1-delta isoform X6

  11. XM_047421442.1 → XP_047277398.1  elongation factor 1-delta isoform X6

  12. XM_047421422.1 → XP_047277378.1  elongation factor 1-delta isoform X1

  13. XM_047421421.1 → XP_047277377.1  elongation factor 1-delta isoform X1

  14. XM_047421432.1 → XP_047277388.1  elongation factor 1-delta isoform X6

  15. XM_047421430.1 → XP_047277386.1  elongation factor 1-delta isoform X6

  16. XM_047421427.1 → XP_047277383.1  elongation factor 1-delta isoform X6

  17. XM_047421424.1 → XP_047277380.1  elongation factor 1-delta isoform X4

  18. XM_006716519.5 → XP_006716582.3  elongation factor 1-delta isoform X2

  19. XM_006716520.5 → XP_006716583.3  elongation factor 1-delta isoform X3

  20. XM_047421420.1 → XP_047277376.1  elongation factor 1-delta isoform X1

  21. XM_047421454.1 → XP_047277410.1  elongation factor 1-delta isoform X10

  22. XM_047421443.1 → XP_047277399.1  elongation factor 1-delta isoform X7

  23. XM_047421447.1 → XP_047277403.1  elongation factor 1-delta isoform X9

  24. XM_047421426.1 → XP_047277382.1  elongation factor 1-delta isoform X6

  25. XM_047421446.1 → XP_047277402.1  elongation factor 1-delta isoform X8

  26. XM_047421425.1 → XP_047277381.1  elongation factor 1-delta isoform X5

  27. XM_047421440.1 → XP_047277396.1  elongation factor 1-delta isoform X6

  28. XM_047421438.1 → XP_047277394.1  elongation factor 1-delta isoform X6

  29. XM_047421437.1 → XP_047277393.1  elongation factor 1-delta isoform X6

  30. XM_047421436.1 → XP_047277392.1  elongation factor 1-delta isoform X6

  31. XM_024447088.2 → XP_024302856.1  elongation factor 1-delta isoform X7

    UniProtKB/TrEMBL
    B2RAR6
    Conserved Domains (2) summary
    pfam00736
    Location:563 → 646
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:524 → 551
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

  32. XM_047421453.1 → XP_047277409.1  elongation factor 1-delta isoform X9

  33. XM_047421439.1 → XP_047277395.1  elongation factor 1-delta isoform X6

  34. XM_047421431.1 → XP_047277387.1  elongation factor 1-delta isoform X6

  35. XM_047421449.1 → XP_047277405.1  elongation factor 1-delta isoform X9

  36. XM_006716522.2 → XP_006716585.1  elongation factor 1-delta isoform X6

    See identical proteins and their annotated locations for XP_006716585.1

    UniProtKB/TrEMBL
    B2RAR6
    Conserved Domains (2) summary
    pfam10587
    Location:525 → 552
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
    pfam00736
    Location:564 → 647
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  37. XM_047421435.1 → XP_047277391.1  elongation factor 1-delta isoform X6

  38. XM_006716524.2 → XP_006716587.1  elongation factor 1-delta isoform X6

    See identical proteins and their annotated locations for XP_006716587.1

    UniProtKB/TrEMBL
    B2RAR6
    Conserved Domains (2) summary
    pfam10587
    Location:525 → 552
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
    pfam00736
    Location:564 → 647
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  39. XM_047421434.1 → XP_047277390.1  elongation factor 1-delta isoform X6

  40. XM_047421444.1 → XP_047277400.1  elongation factor 1-delta isoform X7

  41. XM_047421448.1 → XP_047277404.1  elongation factor 1-delta isoform X9

  42. XM_047421429.1 → XP_047277385.1  elongation factor 1-delta isoform X6

  43. XM_047421452.1 → XP_047277408.1  elongation factor 1-delta isoform X9

  44. XM_047421428.1 → XP_047277384.1  elongation factor 1-delta isoform X6

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187571.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    69768..87455 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328747.1 → XP_054184722.1  elongation factor 1-delta isoform X10

  2. XM_054328738.1 → XP_054184713.1  elongation factor 1-delta isoform X7

  3. XM_054328743.1 → XP_054184718.1  elongation factor 1-delta isoform X9

  4. XM_054328727.1 → XP_054184702.1  elongation factor 1-delta isoform X6

  5. XM_054328734.1 → XP_054184709.1  elongation factor 1-delta isoform X6

  6. XM_054328717.1 → XP_054184692.1  elongation factor 1-delta isoform X1

  7. XM_054328748.1 → XP_054184723.1  elongation factor 1-delta isoform X11

    UniProtKB/Swiss-Prot
    B4DDU4, D3DWK3, E9PBQ9, P29692, Q4VBZ6, Q969J1, Q96I38

  8. XM_054328739.1 → XP_054184714.1  elongation factor 1-delta isoform X7

  9. XM_054328744.1 → XP_054184719.1  elongation factor 1-delta isoform X9

  10. XM_054328730.1 → XP_054184705.1  elongation factor 1-delta isoform X6

  11. XM_054328735.1 → XP_054184710.1  elongation factor 1-delta isoform X6

  12. XM_054328716.1 → XP_054184691.1  elongation factor 1-delta isoform X1

  13. XM_054328715.1 → XP_054184690.1  elongation factor 1-delta isoform X1

  14. XM_054328723.1 → XP_054184698.1  elongation factor 1-delta isoform X6

  15. XM_054328729.1 → XP_054184704.1  elongation factor 1-delta isoform X6

  16. XM_054328728.1 → XP_054184703.1  elongation factor 1-delta isoform X6

  17. XM_054328720.1 → XP_054184695.1  elongation factor 1-delta isoform X4

  18. XM_054328718.1 → XP_054184693.1  elongation factor 1-delta isoform X2

  19. XM_054328719.1 → XP_054184694.1  elongation factor 1-delta isoform X3

  20. XM_054328714.1 → XP_054184689.1  elongation factor 1-delta isoform X1

  21. XM_054328746.1 → XP_054184721.1  elongation factor 1-delta isoform X10

  22. XM_054328736.1 → XP_054184711.1  elongation factor 1-delta isoform X7

  23. XM_054328741.1 → XP_054184716.1  elongation factor 1-delta isoform X9

  24. XM_054328722.1 → XP_054184697.1  elongation factor 1-delta isoform X6

  25. XM_054328740.1 → XP_054184715.1  elongation factor 1-delta isoform X8

  26. XM_054328721.1 → XP_054184696.1  elongation factor 1-delta isoform X5

  27. XM_054328726.1 → XP_054184701.1  elongation factor 1-delta isoform X6

  28. XM_054328733.1 → XP_054184708.1  elongation factor 1-delta isoform X6

  29. XM_054328732.1 → XP_054184707.1  elongation factor 1-delta isoform X6

  30. XM_054328731.1 → XP_054184706.1  elongation factor 1-delta isoform X6

  31. XM_054328737.1 → XP_054184712.1  elongation factor 1-delta isoform X7

  32. XM_054328742.1 → XP_054184717.1  elongation factor 1-delta isoform X9

  33. XM_054328725.1 → XP_054184700.1  elongation factor 1-delta isoform X6

  34. XM_054328745.1 → XP_054184720.1  elongation factor 1-delta isoform X9

  35. XM_054328724.1 → XP_054184699.1  elongation factor 1-delta isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    144729124..144746827 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359944.1 → XP_054215919.1  elongation factor 1-delta isoform X10

  2. XM_054359935.1 → XP_054215910.1  elongation factor 1-delta isoform X7

  3. XM_054359940.1 → XP_054215915.1  elongation factor 1-delta isoform X9

  4. XM_054359924.1 → XP_054215899.1  elongation factor 1-delta isoform X6

  5. XM_054359931.1 → XP_054215906.1  elongation factor 1-delta isoform X6

  6. XM_054359914.1 → XP_054215889.1  elongation factor 1-delta isoform X1

  7. XM_054359945.1 → XP_054215920.1  elongation factor 1-delta isoform X11

    UniProtKB/Swiss-Prot
    B4DDU4, D3DWK3, E9PBQ9, P29692, Q4VBZ6, Q969J1, Q96I38

  8. XM_054359936.1 → XP_054215911.1  elongation factor 1-delta isoform X7

  9. XM_054359941.1 → XP_054215916.1  elongation factor 1-delta isoform X9

  10. XM_054359927.1 → XP_054215902.1  elongation factor 1-delta isoform X6

  11. XM_054359932.1 → XP_054215907.1  elongation factor 1-delta isoform X6

  12. XM_054359913.1 → XP_054215888.1  elongation factor 1-delta isoform X1

  13. XM_054359912.1 → XP_054215887.1  elongation factor 1-delta isoform X1

  14. XM_054359920.1 → XP_054215895.1  elongation factor 1-delta isoform X6

  15. XM_054359926.1 → XP_054215901.1  elongation factor 1-delta isoform X6

  16. XM_054359925.1 → XP_054215900.1  elongation factor 1-delta isoform X6

  17. XM_054359917.1 → XP_054215892.1  elongation factor 1-delta isoform X4

  18. XM_054359915.1 → XP_054215890.1  elongation factor 1-delta isoform X2

  19. XM_054359916.1 → XP_054215891.1  elongation factor 1-delta isoform X3

  20. XM_054359911.1 → XP_054215886.1  elongation factor 1-delta isoform X1

  21. XM_054359943.1 → XP_054215918.1  elongation factor 1-delta isoform X10

  22. XM_054359933.1 → XP_054215908.1  elongation factor 1-delta isoform X7

  23. XM_054359938.1 → XP_054215913.1  elongation factor 1-delta isoform X9

  24. XM_054359919.1 → XP_054215894.1  elongation factor 1-delta isoform X6

  25. XM_054359937.1 → XP_054215912.1  elongation factor 1-delta isoform X8

  26. XM_054359918.1 → XP_054215893.1  elongation factor 1-delta isoform X5

  27. XM_054359923.1 → XP_054215898.1  elongation factor 1-delta isoform X6

  28. XM_054359930.1 → XP_054215905.1  elongation factor 1-delta isoform X6

  29. XM_054359929.1 → XP_054215904.1  elongation factor 1-delta isoform X6

  30. XM_054359928.1 → XP_054215903.1  elongation factor 1-delta isoform X6

  31. XM_054359934.1 → XP_054215909.1  elongation factor 1-delta isoform X7

  32. XM_054359939.1 → XP_054215914.1  elongation factor 1-delta isoform X9

  33. XM_054359922.1 → XP_054215897.1  elongation factor 1-delta isoform X6

  34. XM_054359942.1 → XP_054215917.1  elongation factor 1-delta isoform X9

  35. XM_054359921.1 → XP_054215896.1  elongation factor 1-delta isoform X6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001130054.1: Suppressed sequence

    Description
    NM_001130054.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P29692.5 GenPept UniProtKB/Swiss-Prot:P29692

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