Rad23a RAD23 homolog A, nucleotide excision repair protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rad23aprovided by MGI
Official Full Name: RAD23 homolog A, nucleotide excision repair proteinprovided by MGI
Primary source: MGI:MGI:105126
See related: Ensembl:ENSMUSG00000003813 AllianceGenome:MGI:105126
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HR23A; mHR23A; 2310040P19Rik
Summary: Predicted to enable several functions, including enzyme binding activity; proteasome binding activity; and ubiquitin binding activity. Acts upstream of or within DNA damage response. Predicted to be located in Golgi apparatus and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and nucleoplasm. Is expressed in brain and liver. Orthologous to human RAD23A (RAD23 homolog A, nucleotide excision repair protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E14.5 (RPKM 50.1), liver E14 (RPKM 45.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C3; 8 41.2 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (85561540..85567361, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (84834927..84840652, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data demonstrate that sequestration and impairment of nuclear HR23 and nucleocytoplasmic transport proteins is an outcome of, and a contributor to, poly(GA) pathology.
Title: C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins.
the mammalian RAD23 proteins play a direct role in damage recognition by enhancing the binding of XPC to DNA damage in living cells in addition to stabilizing XPC. RAD23 proteins rapidly dissociated from XPC upon binding to damaged DNA.
Title: Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex.
analysis of mHR23A/B double-mutant cells showed that HR23 proteins function in nucleotide excision repair by governing xeroderma pigmentosum group C protein stability via partial protection against proteasomal degradation
Title: A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rad23a (e-PCR), detects polymorphism
- UniSTS:144315

Rad23a (e-PCR), detects polymorphism
- UniSTS:532436

RH125456 (e-PCR)
- UniSTS:162275

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables polyubiquitin modification-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables proteasome binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-specific protease binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-specific protease binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nucleotide-excision repair	IEA Inferred from Electronic Annotation more info
involved_in nucleotide-excision repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of viral genome replication	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein destabilization	IEA Inferred from Electronic Annotation more info
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: UV excision repair protein RAD23 homolog A

Names: RAD23a homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001297606.2 → NP_001284535.1 UV excision repair protein RAD23 homolog A isoform 1

See identical proteins and their annotated locations for NP_001284535.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AC155163

Consensus CDS

CCDS80908.1

UniProtKB/Swiss-Prot

B7ZNQ1, P54726

Related

ENSMUSP00000105383.3, ENSMUST00000109761.9

Conserved Domains (5) summary

cd01805
Location:3 → 80

RAD23_N; Ubiquitin-like domain of RAD23

cd14377
Location:162 → 201

UBA1_Rad23; UBA1 domain of Rad23 proteins found in metazoa

cd14427
Location:319 → 359

UBA2_HR23A; UBA2 domain of UV excision repair protein RAD23 homolog A (HR23A) found in vertebrates

TIGR00601
Location:3 → 361

rad23; UV excision repair protein Rad23

pfam09280
Location:232 → 287

XPC-binding; XPC-binding domain
NM_001297607.2 → NP_001284536.1 UV excision repair protein RAD23 homolog A isoform 3

See identical proteins and their annotated locations for NP_001284536.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of an exon compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC155163

UniProtKB/TrEMBL

Q3TN85

Related

ENSMUSP00000115664.2, ENSMUST00000128035.2

Conserved Domains (4) summary

cd01805
Location:3 → 80

RAD23_N; Ubiquitin-like domain of RAD23

smart00213
Location:3 → 77

UBQ; Ubiquitin homologues

cd14377
Location:162 → 201

UBA1_Rad23; UBA1 domain of Rad23 proteins found in metazoa

pfam09280
Location:232 → 287

XPC-binding; XPC-binding domain
NM_001378894.1 → NP_001365823.1 UV excision repair protein RAD23 homolog A isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) encodes the longest isoform (4).

Source sequence(s)

AC155163

Conserved Domains (1) summary

TIGR00601
Location:3 → 365

rad23; UV excision repair protein Rad23
NM_001378895.1 → NP_001365824.1 UV excision repair protein RAD23 homolog A isoform 5

Status: VALIDATED

Source sequence(s)

AC155163

Conserved Domains (1) summary

TIGR00601
Location:3 → 364

rad23; UV excision repair protein Rad23
NM_001378896.1 → NP_001365825.1 UV excision repair protein RAD23 homolog A isoform 6

Status: VALIDATED

Source sequence(s)

AC155163

UniProtKB/TrEMBL

Q8BRA9

Conserved Domains (1) summary

TIGR00601
Location:3 → 286

rad23; UV excision repair protein Rad23
NM_009010.6 → NP_033036.2 UV excision repair protein RAD23 homolog A isoform 2

See identical proteins and their annotated locations for NP_033036.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.

Source sequence(s)

AC155163

Consensus CDS

CCDS40414.1

UniProtKB/TrEMBL

Q8CAP3

Related

ENSMUSP00000003911.7, ENSMUST00000003911.13

Conserved Domains (5) summary

cd01805
Location:3 → 80

RAD23_N; Ubiquitin-like domain of RAD23

cd14377
Location:162 → 201

UBA1_Rad23; UBA1 domain of Rad23 proteins found in metazoa

cd14427
Location:318 → 358

UBA2_HR23A; UBA2 domain of UV excision repair protein RAD23 homolog A (HR23A) found in vertebrates

TIGR00601
Location:3 → 360

rad23; UV excision repair protein Rad23

pfam09280
Location:231 → 286

XPC-binding; XPC-binding domain