Pthlh parathyroid hormone-like peptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pthlhprovided by MGI
Official Full Name: parathyroid hormone-like peptideprovided by MGI
Primary source: MGI:MGI:97800
See related: Ensembl:ENSMUSG00000048776 AllianceGenome:MGI:97800
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PLP; Pthrp; PTH-like
Summary: This gene encodes a member of the parathyroid family of hormones that possesses distinct paracrine and intracrine signaling roles such as regulation of circulating calcium, transplacental calcium transport, osteoclast inhibition, renal bicarbonate excretion and regulation of apoptosis. The encoded protein undergoes proteolytic processing to generate multiple active peptides with distinct signaling functions. The homozygous deletion of this gene leads to death shortly after birth with a chondrodystrophic phenotype characterized by premature chondrocyte differentiation and accelerated bone formation. [provided by RefSeq, Jul 2015]
Expression: Biased expression in bladder adult (RPKM 46.9) and limb E14.5 (RPKM 6.1) See more
Orthologs: human all
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Genomic context

Location:: 6 G3; 6 78.19 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (147153607..147165511, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (147252109..147264013, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intermittent mechanical loading on mouse tibia accelerates longitudinal bone growth by inducing PTHrP expression in the female tibial growth plate.
Title: Intermittent mechanical loading on mouse tibia accelerates longitudinal bone growth by inducing PTHrP expression in the female tibial growth plate.
A PTHrP Gradient Drives Mandibular Condylar Chondrogenesis via Runx2.
Title: A PTHrP Gradient Drives Mandibular Condylar Chondrogenesis via Runx2.
CaSR modulates proliferation of the superficial zone cells in temporomandibular joint cartilage via the PTHrP nuclear localization sequence.
Title: CaSR modulates proliferation of the superficial zone cells in temporomandibular joint cartilage via the PTHrP nuclear localization sequence.
The nuclear localization sequence and C-terminus of parathyroid hormone-related protein regulate normal pancreatic islet development and function.
Title: The nuclear localization sequence and C-terminus of parathyroid hormone-related protein regulate normal pancreatic islet development and function.
Cranial Base Synchondrosis Lacks PTHrP-Expressing Column-Forming Chondrocytes.
Title: Cranial Base Synchondrosis Lacks PTHrP-Expressing Column-Forming Chondrocytes.
PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development.
Title: PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development.
PTHrP promotes development of mouse preimplantation embryos through the AKT/cyclin D1 pathway and nuclear translocation of HDAC4.
Title: PTHrP promotes development of mouse preimplantation embryos through the AKT/cyclin D1 pathway and nuclear translocation of HDAC4.
Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment.
Title: Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment.
Dmp1Cre-directed knockdown of parathyroid hormone-related protein (PTHrP) in murine decidua is associated with a life-long increase in bone mass, width, and strength in male progeny.
Title: Dmp1Cre-directed knockdown of parathyroid hormone-related protein (PTHrP) in murine decidua is associated with a life-long increase in bone mass, width, and strength in male progeny.
Effect of Parathyroid Hormone on Intestinal Mucosal Sodium Dependent Phosphorus Transporter.
Title: Effect of Parathyroid Hormone on Intestinal Mucosal Sodium Dependent Phosphorus Transporter.

Submit: New GeneRIF Correction See all GeneRIFs (116)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (7) 1 citation

General gene information

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Markers

PMC229353P1 (e-PCR)
- UniSTS:272174

Pthlh (e-PCR), detects polymorphism
- UniSTS:547918

Pthlh (e-PCR), detects polymorphism
- UniSTS:279422

RH94501 (e-PCR)
- UniSTS:119749

D6Mit26 (e-PCR), detects polymorphism
- UniSTS:130808

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	ISO Inferred from Sequence Orthology more info
enables hormone activity	TAS Traceable Author Statement more info	PubMed
enables peptide hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables peptide hormone receptor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion homeostasis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endochondral ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endoderm development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lung alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in magnesium ion homeostasis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within mammary gland bud elongation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of chondrocyte development	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within negative regulation of chondrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of chondrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within nipple sheath formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoblast development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within osteoblast development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphate ion homeostasis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein processing	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of chondrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal system development	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within surfactant homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular space	TAS Traceable Author Statement more info	PubMed
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: parathyroid hormone-related protein

Names: PTH-related peptide; parathyroid hormone-like hormone; parathyroid hormone-like protein; parathyroid hormone-related peptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.