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Eif4a3 eukaryotic translation initiation factor 4A3 [ Mus musculus (house mouse) ]

Gene ID: 192170, updated on 28-Oct-2024

Summary

Official Symbol
Eif4a3provided by MGI
Official Full Name
eukaryotic translation initiation factor 4A3provided by MGI
Primary source
MGI:MGI:1923731
See related
Ensembl:ENSMUSG00000025580 AllianceGenome:MGI:1923731
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ddx48; eIF4A-III; mKIAA0111; 2400003O03Rik
Summary
Predicted to enable several functions, including ATP binding activity; RNA binding activity; and RNA helicase activity. Acts upstream of or within positive regulation of mRNA splicing, via spliceosome and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in submandibular gland primordium; telencephalon; testis; and vibrissa. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human EIF4A3 (eukaryotic translation initiation factor 4A3). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 64.0), limb E14.5 (RPKM 53.1) and 28 other tissues See more
Orthologs
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Genomic context

See Eif4a3 in Genome Data Viewer
Location:
11 E2; 11 83.35 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (119179189..119190869, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (119288363..119300043, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 40 Neighboring gene predicted gene, 46303 Neighboring gene STARR-positive B cell enhancer mm9_chr11:119129170-119129471 Neighboring gene glucosidase, alpha, acid Neighboring gene predicted gene, 39483 Neighboring gene STARR-positive B cell enhancer ABC_E7111 Neighboring gene caspase recruitment domain family, member 14 Neighboring gene N-sulfoglucosamine sulfohydrolase (sulfamidase) Neighboring gene solute carrier family 26, member 11 Neighboring gene STARR-seq mESC enhancer starr_31317

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC6664, MGC6715

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA stem-loop binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables poly(A) binding ISO
Inferred from Sequence Orthology
more info
 
enables ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
 
enables selenocysteine insertion sequence binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in embryonic cranial skeleton morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic cranial skeleton morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mRNA export from nucleus NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of selenocysteine incorporation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of alternative mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of translation at postsynapse, modulating synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of U2-type catalytic step 1 spliceosome ISO
Inferred from Sequence Orthology
more info
 
part_of U2-type catalytic step 1 spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
part_of exon-exon junction complex ISO
Inferred from Sequence Orthology
more info
 
part_of exon-exon junction complex ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
eukaryotic initiation factor 4A-III
Names
ATP-dependent RNA helicase DDX48
ATP-dependent RNA helicase eIF4A-3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 48
DEAD box protein 48
eIF-4A-III
NP_619610.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138669.1NP_619610.1  eukaryotic initiation factor 4A-III

    See identical proteins and their annotated locations for NP_619610.1

    Status: PROVISIONAL

    Source sequence(s)
    BC008132
    Consensus CDS
    CCDS25714.1
    UniProtKB/Swiss-Prot
    B2RY38, Q3TEZ8, Q3UD29, Q8BVY3, Q91VC3
    UniProtKB/TrEMBL
    A0A0N4SVP8
    Related
    ENSMUSP00000026667.9, ENSMUST00000026667.15
    Conserved Domains (3) summary
    PTZ00424
    Location:35411
    PTZ00424; helicase 45; Provisional
    cd00079
    Location:251380
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:40240
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    119179189..119190869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)