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glra3 glycine receptor, alpha 3 [ Danio rerio (zebrafish) ]

Gene ID: 192124, updated on 2-Nov-2024

Summary

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Official Symbol
glra3provided by ZNC
Official Full Name
glycine receptor, alpha 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-020402-1
See related
Ensembl:ENSDARG00000011066 AllianceGenome:ZFIN:ZDB-GENE-020402-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
glyRalpha3
Summary
Enables extracellularly glycine-gated ion channel activity. Acts upstream of or within excitatory postsynaptic potential and monoatomic ion transmembrane transport. Predicted to be located in cell projection and plasma membrane. Predicted to be part of chloride channel complex. Is expressed in hindbrain and spinal cord. Orthologous to human GLRA3 (glycine receptor alpha 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See glra3 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (38416268..38538193, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (37698138..37818921, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 44 Neighboring gene F-box protein 8 Neighboring gene 15-hydroxyprostaglandin dehydrogenase Neighboring gene glycoprotein M6Ab Neighboring gene WD repeat domain 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Extrasynaptic homomeric glycine receptors in neurons of the rat trigeminal mesencephalic nucleus. Bae JY, et al. Brain Struct Funct, 2018 Jun. PMID 29460053
  2. Glycine Receptor Autoantibodies Impair Receptor Function and Induce Motor Dysfunction. Rauschenberger V, et al. Ann Neurol, 2020 Sep. PMID 32588476
  3. Characterization of the Zebrafish Glycine Receptor Family Reveals Insights Into Glycine Receptor Structure Function and Stoichiometry. Low SE, et al. Front Mol Neurosci, 2018. PMID 30323738, Free PMC Article
  4. Distinct phenotypes in zebrafish models of human startle disease. Ganser LR, et al. Neurobiol Dis, 2013 Dec. PMID 24029548, Free PMC Article
  5. Defective escape behavior in DEAH-box RNA helicase mutants improved by restoring glycine receptor expression. Hirata H, et al. J Neurosci, 2013 Sep 11. PMID 24027265, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study showed that Extrasynaptic localization of GlyRalpha3 in the neuron in trigeminal mesencephalic nucleus.
    Title: Extrasynaptic homomeric glycine receptors in neurons of the rat trigeminal mesencephalic nucleus.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables extracellularly glycine-gated ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycine binding IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chloride transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within excitatory postsynaptic potential IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glycine receptor subunit alpha-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152965.1 → NP_694497.1  glycine receptor subunit alpha-3 precursor

    See identical proteins and their annotated locations for NP_694497.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ308516
    UniProtKB/TrEMBL
    Q90W14
    Related
    ENSDARP00000012434.7, ENSDART00000009777.9
    Conserved Domains (3) summary
    TIGR00860
    Location:12 → 439
    LIC; Cation transporter family protein
    pfam02931
    Location:47 → 253
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:260 → 436
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    38416268..38538193 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021477569.2 → XP_021333244.1  glycine receptor subunit alpha-3 isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q7Y2
    Conserved Domains (1) summary
    TIGR00860
    Location:13 → 478
    LIC; Cation transporter family protein
Nucleotide Protein Strain
Heading Accession and Version

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Research Materials