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ppt-1 Palmitoyl-protein thioesterase 1 [ Caenorhabditis elegans ]

Gene ID: 191744, updated on 2-Nov-2024

Summary

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Official Symbol
ppt-1
Official Full Name
Palmitoyl-protein thioesterase 1
Primary source
WormBase:WBGene00004092
Locus tag
CELE_F44C4.5
See related
AllianceGenome:WB:WBGene00004092
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables palmitoyl-(protein) hydrolase activity. Involved in several processes, including egg-laying behavior; mitochondrion organization; and protein catabolic process. Predicted to be active in extracellular region and lysosome. Used to study neuronal ceroid lipofuscinosis. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 1. Orthologous to human PPT1 (palmitoyl-protein thioesterase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ppt-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (6624701..6626344, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Nuclear Hormone Receptor family Neighboring gene ncRNA Neighboring gene ALK tyrosine kinase receptor homolog scd-2 Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene EF-hand domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of Caenorhabditis elegans palmitoyl protein thioesterase1. Porter MY, et al. J Neurosci Res, 2005 Mar 15. PMID 15672447
  2. Subcellular Nanorheology Reveals Lysosomal Viscosity as a Reporter for Lysosomal Storage Diseases. Devany J, et al. Nano Lett, 2018 Feb 14. PMID 29313356
  3. A systematic analysis of protein palmitoylation in Caenorhabditis elegans. Edmonds MJ, et al. BMC Genomics, 2014 Oct 2. PMID 25277130, Free PMC Article
  4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  5. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables palmitoyl hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyl-(protein) hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables palmitoyl-(protein) hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables palmitoyl-(protein) hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in macromolecule depalmitoylation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Palmitoyl-protein thioesterase 1
NP_504684.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    6624701..6626344 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072283.6 → NP_504684.2  Palmitoyl-protein thioesterase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504684.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20390, Q68GX0
    Conserved Domains (1) summary
    cl21494
    Location:25 → 293
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20390.2

Gene LinkOut

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