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ins-4 putative insulin-like peptide beta-type 1 [ Caenorhabditis elegans ]

Gene ID: 191685, updated on 2-Nov-2024

Summary

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Official Symbol
ins-4
Official Full Name
putative insulin-like peptide beta-type 1
Primary source
WormBase:WBGene00002087
Locus tag
CELE_ZK75.1
See related
AllianceGenome:WB:WBGene00002087
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable hormone activity. Involved in dauer larval development; negative regulation of dauer entry; and regulation of synaptic assembly at neuromuscular junction. Predicted to be located in extracellular region. Is expressed in several structures, including gonad; head muscle; neurons; somatic nervous system; and vulva. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ins-4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003280.10 (5996366..5997008)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene putative insulin-like peptide beta-type 2 Neighboring gene putative insulin-like peptide beta-type 3 Neighboring gene Putative insulin-like peptide beta-type 6 Neighboring gene putative insulin-like peptide beta-type 5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. BMP pathway regulation of insulin signaling components promotes lipid storage in Caenorhabditis elegans. Clark JF, et al. PLoS Genet, 2021 Oct. PMID 34634043, Free PMC Article
  2. Pheromones Modulate Learning by Regulating the Balanced Signals of Two Insulin-like Peptides. Wu T, et al. Neuron, 2019 Dec 18. PMID 31676170, Free PMC Article
  3. L1 arrest, daf-16/FoxO and nonautonomous control of post-embryonic development. Kaplan RE, et al. Worm, 2016 Apr-Jun. PMID 27383290, Free PMC Article
  4. Males shorten the life span of C. elegans hermaphrodites via secreted compounds. Maures TJ, et al. Science, 2014 Jan 31. PMID 24292626, Free PMC Article
  5. Neuronal ERK MAPK signaling in response to low-dose nanopolystyrene exposure by suppressing insulin peptide expression in Caenorhabditis elegans. Qu M, et al. Sci Total Environ, 2020 Jul 1. PMID 32272418

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ins-4 and daf-28 function redundantly to regulate C. elegans L1 arrest.
    Title: Ins-4 and daf-28 function redundantly to regulate C. elegans L1 arrest.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dauer larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of dauer entry IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of synaptic assembly at neuromuscular junction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative insulin-like peptide beta-type 1
NP_495196.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5996366..5997008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062795.2 → NP_495196.1  putative insulin-like peptide beta-type 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495196.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09626
    Conserved Domains (1) summary
    pfam03488
    Location:57 → 104
    Ins_beta; Nematode insulin-related peptide beta type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09626.1

Gene LinkOut

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