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ins-3 putative insulin-like peptide beta-type 3 [ Caenorhabditis elegans ]

Gene ID: 191684, updated on 17-Oct-2024

Summary

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Official Symbol
ins-3
Official Full Name
putative insulin-like peptide beta-type 3
Primary source
WormBase:WBGene00002086
Locus tag
CELE_ZK75.3
See related
AllianceGenome:WB:WBGene00002086
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable hormone activity. Involved in dauer larval development and negative regulation of dauer entry. Predicted to be located in extracellular region. Is expressed in several structures, including coelomocyte; egg-laying apparatus; gonad; head muscle; and nervous system. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ins-3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003280.10 (5990099..5990768, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene putative insulin-like peptide beta-type 2 Neighboring gene putative insulin-like peptide beta-type 1 Neighboring gene Putative insulin-like peptide beta-type 6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Insulin signaling promotes germline proliferation in C. elegans. Michaelson D, et al. Development, 2010 Feb. PMID 20110332, Free PMC Article
  2. Ins-4 and daf-28 function redundantly to regulate C. elegans L1 arrest. Chen Y, et al. Dev Biol, 2014 Oct 15. PMID 25128585
  3. A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication. Hung WL, et al. Development, 2014 Apr. PMID 24671950, Free PMC Article
  4. Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development. Hung WL, et al. EMBO J, 2013 Jun 12. PMID 23665919, Free PMC Article
  5. Cell-Autonomous and Non-Cell-Autonomous Regulation of a Feeding State-Dependent Chemoreceptor Gene via MEF-2 and bHLH Transcription Factors. Gruner M, et al. PLoS Genet, 2016 Aug. PMID 27487365, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dauer larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of dauer entry IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative insulin-like peptide beta-type 3
NP_495195.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5990099..5990768 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062794.9 → NP_495195.1  putative insulin-like peptide beta-type 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495195.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09628
    Conserved Domains (1) summary
    pfam03488
    Location:59 → 105
    Ins_beta; Nematode insulin-related peptide beta type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09628.1

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