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gcy-36 Soluble guanylate cyclase gcy-36 [ Caenorhabditis elegans ]

Gene ID: 191657, updated on 12-Jun-2024

Summary

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Gene symbol
gcy-36
Gene description
Soluble guanylate cyclase gcy-36
Locus tag
CELE_C46E1.2
See related
AllianceGenome:WB:WBGene00001556
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables oxygen sensor activity. Involved in feeding behavior and response to oxygen levels. Located in dendrite and neuronal cell body. Is expressed in AQR; PQR; URXL; and URXR. Orthologous to human GUCY1B1 (guanylate cyclase 1 soluble subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See gcy-36 in Genome Data Viewer
Location:
chromosome: X
Exon count:
14
Sequence:
Chromosome: X; NC_003284.9 (15479017..15485711)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene IRG-type G domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of Neuronal Oxygen Responses in C. elegans Is Mediated through Interactions between Globin 5 and the H-NOX Domains of Soluble Guanylate Cyclases. Abergel Z, et al. J Neurosci, 2016 Jan 20. PMID 26791224, Free PMC Article
  2. Mutations in a guanylate cyclase GCY-35/GCY-36 modify Bardet-Biedl syndrome-associated phenotypes in Caenorhabditis elegans. Mok CA, et al. PLoS Genet, 2011 Oct. PMID 22022287, Free PMC Article
  3. GCY-35/GCY-36-TAX-2/TAX-4 Signalling in O(2) Sensory Neurons Mediates Acute Functional Ethanol Tolerance in Caenorhabditis elegans. Chen YH, et al. Sci Rep, 2018 Feb 14. PMID 29445226, Free PMC Article
  4. Experience-dependent modulation of C. elegans behavior by ambient oxygen. Cheung BH, et al. Curr Biol, 2005 May 24. PMID 15916947
  5. Can oxygen anosmia extend lifespan? Abergel R, et al. Aging (Albany NY), 2017 Nov 30. PMID 29190215, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The loss of GCY-35 or GCY-36 results in suppression of the small body size, developmental delay, and exploration defects exhibited by multiple bbs mutants
    Title: Mutations in a guanylate cyclase GCY-35/GCY-36 modify Bardet-Biedl syndrome-associated phenotypes in Caenorhabditis elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables guanylate cyclase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxygen sensor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cGMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in feeding behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxygen levels IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxygen levels IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to stimulus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
part_of guanylate cyclase complex, soluble IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Soluble guanylate cyclase gcy-36
NP_510557.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    15479017..15485711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078156.8 → NP_510557.3  Soluble guanylate cyclase gcy-36 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510557.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6DNF4, Q9XTE0
    Conserved Domains (4) summary
    smart00044
    Location:415 → 604
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:441 → 624
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:3 → 167
    HNOB; Haem-NO-binding
    pfam07701
    Location:217 → 435
    HNOBA; Heme NO binding associated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DNF4.1

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