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Pde9a phosphodiesterase 9A [ Rattus norvegicus (Norway rat) ]

Gene ID: 191569, updated on 17-Aug-2024

Summary

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Official Symbol
Pde9aprovided by RGD
Official Full Name
phosphodiesterase 9Aprovided by RGD
Primary source
RGD:621035
See related
EnsemblRapid:ENSRNOG00000001174 AllianceGenome:RGD:621035
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables 3',5'-cyclic-GMP phosphodiesterase activity. Involved in cGMP-mediated signaling. Located in perikaryon. Orthologous to human PDE9A (phosphodiesterase 9A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 75.8), Kidney (RPKM 67.7) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
20p12
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (9471136..9564286)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (9469809..9562949)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (10123624..10216325)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098980 Neighboring gene solute carrier family 37 member 1 Neighboring gene uncharacterized LOC120098916 Neighboring gene uncharacterized LOC103694394 Neighboring gene uncharacterized LOC134483878 Neighboring gene WD repeat domain 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Sex-dimorphic gene effects on survival outcomes in people with coronary artery disease. Dungan JR, et al. Am Heart J Plus, 2022 May. PMID 35959094, Free PMC Article
  2. CRD-733, a Novel PDE9 (Phosphodiesterase 9) Inhibitor, Reverses Pressure Overload-Induced Heart Failure. Richards DA, et al. Circ Heart Fail, 2021 Jan. PMID 33464954, Free PMC Article
  3. PDE9 inhibition promotes proliferation of neural stem cells via cGMP-PKG pathway following oxygen-glucose deprivation/reoxygenation injury in vitro. Huan X, et al. Neurochem Int, 2020 Feb. PMID 31821840
  4. The Novel Phosphodiesterase 9A Inhibitor BI 409306 Increases Cyclic Guanosine Monophosphate Levels in the Brain, Promotes Synaptic Plasticity, and Enhances Memory Function in Rodents. Rosenbrock H, et al. J Pharmacol Exp Ther, 2019 Dec. PMID 31578258
  5. Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia. Wu Y, et al. J Med Chem, 2019 Apr 25. PMID 30916555

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cGMP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cGMP catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cGMP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cGMP catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cGMP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cGMP metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cardiac muscle hypertrophy ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perikaryon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
  
located_in sarcolemma ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
NP_612552.1
XP_008771015.1
XP_008771016.1
XP_008771017.1
XP_038954338.1
XP_038954339.1
XP_063135018.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138543.1 → NP_612552.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

    See identical proteins and their annotated locations for NP_612552.1

    Status: PROVISIONAL

    Source sequence(s)
    AF372654
    UniProtKB/Swiss-Prot
    F1LRG6, Q8QZV1
    UniProtKB/TrEMBL
    A0A8I6ALK2
    Related
    ENSRNOP00000001559.7, ENSRNOT00000001559.9
    Conserved Domains (1) summary
    pfam00233
    Location:250 → 478
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    9471136..9564286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098411.2 → XP_038954339.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X3

    Conserved Domains (1) summary
    cl21469
    Location:250 → 273
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

  2. XM_008772793.4 → XP_008771015.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1

    See identical proteins and their annotated locations for XP_008771015.1

    UniProtKB/Swiss-Prot
    F1LRG6, Q8QZV1
    UniProtKB/TrEMBL
    A0A8I6ALK2
    Conserved Domains (1) summary
    pfam00233
    Location:250 → 478
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  3. XM_008772794.4 → XP_008771016.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1

    See identical proteins and their annotated locations for XP_008771016.1

    UniProtKB/Swiss-Prot
    F1LRG6, Q8QZV1
    UniProtKB/TrEMBL
    A0A8I6ALK2
    Related
    ENSRNOP00000110403.1, ENSRNOT00000131269.1
    Conserved Domains (1) summary
    pfam00233
    Location:250 → 478
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  4. XM_008772795.4 → XP_008771017.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1

    See identical proteins and their annotated locations for XP_008771017.1

    UniProtKB/Swiss-Prot
    F1LRG6, Q8QZV1
    UniProtKB/TrEMBL
    A0A8I6ALK2
    Related
    ENSRNOP00000100376.1, ENSRNOT00000165087.1
    Conserved Domains (1) summary
    pfam00233
    Location:250 → 478
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  5. XM_063278948.1 → XP_063135018.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2

    UniProtKB/TrEMBL
    A0A8I6AL01, A6JJZ6
    Related
    ENSRNOP00000095194.1, ENSRNOT00000095394.2

  6. XM_039098410.2 → XP_038954338.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2

    UniProtKB/TrEMBL
    A0A8I6AL01, A6JJZ6
    Conserved Domains (1) summary
    pfam00233
    Location:128 → 356
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8QZV1.1 GenPept UniProtKB/Swiss-Prot:Q8QZV1

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