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Prep prolyl endopeptidase [ Mus musculus (house mouse) ]

Gene ID: 19072, updated on 2-Nov-2024

Summary

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Official Symbol
Prepprovided by MGI
Official Full Name
prolyl endopeptidaseprovided by MGI
Primary source
MGI:MGI:1270863
See related
Ensembl:ENSMUSG00000019849 AllianceGenome:MGI:1270863
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PE; PEP; Pop; D10Wsu136e
Summary
Predicted to enable oligopeptidase activity and peptide binding activity. Predicted to be involved in protein catabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including cranial ganglion; genitourinary system; heart ventricle; thymus primordium; and vibrissa. Orthologous to human PREP (prolyl endopeptidase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 28.1), placenta adult (RPKM 26.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Prep in Genome Data Viewer
Location:
10 B2; 10 23.27 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (44943312..45038847)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (45067216..45162751)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40639 Neighboring gene STARR-positive B cell enhancer ABC_E5136 Neighboring gene STARR-seq mESC enhancer starr_26566 Neighboring gene RIKEN cDNA 2310075K07 gene Neighboring gene STARR-seq mESC enhancer starr_26567 Neighboring gene STARR-seq mESC enhancer starr_26571 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:44823099-44823208 Neighboring gene STARR-seq mESC enhancer starr_26573 Neighboring gene STARR-seq mESC enhancer starr_26574 Neighboring gene VISTA enhancer mm87 Neighboring gene STARR-seq mESC enhancer starr_26575 Neighboring gene predicted gene, 26016 Neighboring gene predicted gene 15934 Neighboring gene popeye domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression and localization of prolyl oligopeptidase in mouse testis and its possible involvement in sperm motility. Kimura A, et al. Zoolog Sci, 2002 Jan. PMID 12025410
  2. Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice. Kim JD, et al. Proc Natl Acad Sci U S A, 2014 Aug 12. PMID 25071172, Free PMC Article
  3. A long non-coding RNA transcribed from conserved non-coding sequences contributes to the mouse prolyl oligopeptidase gene activation. Matsubara S, et al. J Biochem, 2014 Apr. PMID 24369296
  4. Prolyl oligopeptidase binds to GAP-43 and functions without its peptidase activity. Di Daniel E, et al. Mol Cell Neurosci, 2009 Jul. PMID 19332125
  5. Prolyl Endopeptidase (PREP) is Associated With Male Reproductive Functions and Gamete Physiology in Mice. Dotolo R, et al. J Cell Physiol, 2016 Mar. PMID 26332268

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A.
    Title: Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A.
  2. POP regulates progesterone secretion by stimulating the expression of CYP11A, 3beta-HSD, and StAR in luteal cells. ERK signaling and downstream SF1 expression contribute to this process.
    Title: Prolyl oligopeptidase regulates progesterone secretion via the ERK signaling pathway in murine luteal cells.
  3. Results strongly suggest that there is a pivotal role for Prolyl endopeptidase (PREP) in vesicle exocytosis, as well as in the physiology of mouse seminal vesicles.
    Title: Study on PREP localization in mouse seminal vesicles and its possible involvement during regulated exocytosis.
  4. Prolyl oligopeptidase expression and role in the placental spongiotrophoblast differentiation.
    Title: A molecular mechanism of mouse placental spongiotrophoblast differentiation regulated by prolyl oligopeptidase.
  5. PREP regulates the function of dopamine transporter, possibly by controlling the phosphorylation and transport of dopamine transporter into the striatum or synaptic membrane.
    Title: Prolyl Oligopeptidase Regulates Dopamine Transporter Phosphorylation in the Nigrostriatal Pathway of Mouse.
  6. Taken together, these data suggest that PREP can enhance alpha-synuclein toxicity in vivo.
    Title: Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo.
  7. involved in trophoblast stem cell differentiation in placenta
    Title: Mouse prolyl oligopeptidase plays a role in trophoblast stem cell differentiation into trophoblast giant cell and spongiotrophoblast.
  8. These findings might be explained as possible alteration in brain plasticity caused by PREP deficiency, which in turn affect behaviour and brain development
    Title: Deficiency of prolyl oligopeptidase in mice disturbs synaptic plasticity and reduces anxiety-like behaviour, body weight, and brain volume.
  9. Lung ischemia-reperfusion injury causes a dysregulation of circulating Ang 2 levels and plasma PREP activity, although no direct link between both phenomena could be shown.
    Title: Dysregulation of the renin-angiotensin system during lung ischemia-reperfusion injury.
  10. TLR4 activation releases prolyl endopeptidase containing exosomes from airway epithelial cells.
    Title: Toll-Like Receptor 4 Engagement Mediates Prolyl Endopeptidase Release from Airway Epithelia via Exosomes.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3)  1 citation
  • Gene trapped (1) 
  • Targeted (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables oligopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables peptide binding ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
prolyl endopeptidase
Names
post-proline cleaving enzyme
prolyl oligopeptidase
NP_035286.1
XP_011241444.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011156.3 → NP_035286.1  prolyl endopeptidase

    See identical proteins and their annotated locations for NP_035286.1

    Status: VALIDATED

    Source sequence(s)
    AC153535, AK076257, AK163774, BP759584
    Consensus CDS
    CCDS23826.1
    UniProtKB/Swiss-Prot
    Q80YS1, Q9QUR6
    UniProtKB/TrEMBL
    Q3TCS0, Q543B9
    Related
    ENSMUSP00000097444.3, ENSMUST00000099858.4
    Conserved Domains (2) summary
    COG1505
    Location:26 → 704
    PreP; Prolyl oligopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism]
    pfam00326
    Location:482 → 707
    Peptidase_S9; Prolyl oligopeptidase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    44943312..45038847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243142.3 → XP_011241444.1  prolyl endopeptidase isoform X1

    Conserved Domains (1) summary
    COG1505
    Location:9 → 477
    PreP; Prolyl oligopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QUR6.1 GenPept UniProtKB/Swiss-Prot:Q9QUR6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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